Synthetic osteochondral composite and method of fabrication thereof
First Claim
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1. An osteochondral composite, comprising:
- a) a porous supportive base defining an upper surface and a lower surface; and
,b) a scaffolding layer defining an upper surface and a lower surface, wherein the lower surface of the scaffolding layer is formed within a plurality of pores of the porous support base to mechanically interlock with the upper surface of the porous supportive base, and wherein the scaffolding layer includes a hydrogel having biological cells implanted therein.
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Abstract
An osteochondral composite including a hydrogel with implanted biological cells joined to a porous supportive base at a mechanically-interlocked interface is disclosed. A method of fabricating the osteochondral composite and a method of treating damaged or diseased articular cartilage by implanting an osteochondral composite are also disclosed.
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Citations
41 Claims
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1. An osteochondral composite, comprising:
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a) a porous supportive base defining an upper surface and a lower surface; and
,b) a scaffolding layer defining an upper surface and a lower surface, wherein the lower surface of the scaffolding layer is formed within a plurality of pores of the porous support base to mechanically interlock with the upper surface of the porous supportive base, and wherein the scaffolding layer includes a hydrogel having biological cells implanted therein. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12)
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13. An osteochondral composite, having three mechanically interlocked layers, the layers comprising:
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a) a porous base layer defining an upper surface and a lower surface; b) a transitional layer defining an upper surface and a lower surface, wherein the lower surface of the transitional layer is formed within a first plurality of pores of the porous base layer to mechanically interlock with the upper surface of the porous base layer; and
,c) a scaffolding layer defining an upper surface and a lower surface wherein the lower surface of the scaffolding layer is formed within a first plurality of pores of the porous base layer to mechanically interlock with the upper surface of the transitional layer, wherein the scaffolding layer further includes a hydrogel with implanted biologic cells. - View Dependent Claims (14, 15, 16, 17, 18, 19, 20, 21, 22, 23)
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24. A method of fabricating an osteochondral composite comprising:
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a) providing a suspension comprising polymer and biological cells; b) providing a porous base defining a plurality of pores, an upper surface and a lower surface; c) submerging the upper surface of the porous base in the suspension to a predetermined depth; and d) crosslinking the polymer within the plurality of pores such that a hydrogel is formed and is mechanically interlocked with the porous base. - View Dependent Claims (25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38)
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39. A method of treating diseased or damaged articular cartilage in a vertebrate animal, comprising:
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a) providing an osteochondral composite comprising a porous base defining a plurality of pores mechanically interlocked to a hydrogel with implanted biological cells, wherein at least a portion of the hydrogel is formed within the plurality of pores; and
,b) implanting the osteochondral composite into a joint of the vertebrate animal. - View Dependent Claims (40, 41)
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Specification