Viable tissue repair implants and methods of use
First Claim
1. A biocompatible tissue implant for repairing a tissue injury or defect, comprising:
- (i) a biological tissue slice having a geometry suitable for implantation at the tissue site, the tissue slice being capable of acting as a source of an effective amount of viable cells, and further being dimensioned so that the cells can migrate out of the tissue slice to proliferate and integrate with tissue at the injury or defect, and(ii) at least one minced tissue fragment associated with the tissue slice and containing a plurality of viable cells.
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Abstract
Biocompatible tissue implants are provided for repairing a tissue injury or defect. The tissue implants comprise a biological tissue slice that serves as a source of viable cells capable of tissue regeneration and/or repair. The biological tissue slice can be harvested from healthy tissue to have a geometry that is suitable for implantation at the site of the injury or defect. The harvested tissue slice is dimensioned to allow the viable cells contained within the tissue slice to migrate out and proliferate and integrate with tissue surrounding the injury or defect site. Methods for repairing a tissue injury or defect using the tissue implants are also provided.
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Citations
18 Claims
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1. A biocompatible tissue implant for repairing a tissue injury or defect, comprising:
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(i) a biological tissue slice having a geometry suitable for implantation at the tissue site, the tissue slice being capable of acting as a source of an effective amount of viable cells, and further being dimensioned so that the cells can migrate out of the tissue slice to proliferate and integrate with tissue at the injury or defect, and (ii) at least one minced tissue fragment associated with the tissue slice and containing a plurality of viable cells. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15)
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16. A method for repairing a tissue injury or defect, comprising:
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providing (i) a biocompatible tissue implant comprising a biological tissue slice having a geometry suitable for implantation at a tissue injury or defect site, the tissue slice being capable of acting as a source of an effective amount of viable cells, and further being dimensioned so that the cells can migrate out of the tissue slice to proliferate and integrate with tissue at the tissue injury or defect site and (ii) at least one minced tissue fragment containing a plurality of viable cells; associating the at least one minced tissue fragment with the tissue slice; and delivering the implant to the tissue site to be repaired. - View Dependent Claims (17, 18)
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Specification