Excipients for protein stabilization
First Claim
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1. A method of minimizing or preventing protein aggregation comprising reacting a compound bearing (1) one or more carbonyl groups and (2) a charge or a bulky group with a protein and forming a reversible Schiff bond with an amino group of the protein surface, where the compound is selected from the group consisting of:
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Abstract
This invention is a method of using a class of excipients for protein formulation to reduce and/or eliminate protein aggregation in solutions or solids. This class of compounds contains carbonyl group(s) to form Schiff base(s) with amino groups of proteins and also contains moieties to keep protein molecules spatially separated. This method has never been disclosed anywhere in the literature.
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6 Claims
- 1. A method of minimizing or preventing protein aggregation comprising reacting a compound bearing (1) one or more carbonyl groups and (2) a charge or a bulky group with a protein and forming a reversible Schiff bond with an amino group of the protein surface, where the compound is selected from the group consisting of:
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2. A method of minimizing or preventing protein aggregation comprising reacting a compound bearing (1) one or more carbonyl groups and (2) a charge or a bulky group with a protein and forming a reversible Schiff bond with an amino group of the protein surface, where the compound is 2-formylbenzenesulfonic acid.
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4. A method of minimizing or preventing protein aggregation comprising reacting a compound bearing (1) one or more carbonyl groups and (2) a charge or a bulky group with a protein and forming a reversible Schiff bond with an amino group of the protein surface, where the compound is 4-formylbenzoic acid.
Specification