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Excipients for protein stabilization

  • US 8,642,532 B2
  • Filed: 11/17/2008
  • Issued: 02/04/2014
  • Est. Priority Date: 11/16/2007
  • Status: Expired due to Fees
First Claim
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1. A method of minimizing or preventing protein aggregation comprising reacting a compound bearing (1) one or more carbonyl groups and (2) a charge or a bulky group with a protein and forming a reversible Schiff bond with an amino group of the protein surface, where the compound is selected from the group consisting of:

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