Glucagon analogues
First Claim
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1. A compound having the formula R1—
- X—
Z—
R2 whereinR1 is hydrogen, C1-4 alkyl, acetyl, formyl, benzoyl or trifluoroacetyl;
R2 is OH or NH2;
X is a peptide which has the formula I
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Abstract
The invention provides materials and methods for promoting weight loss or preventing weight gain, and in the treatment of diabetes, metablic syndrome and associated disorders. In particular, the invention provides novel glucagon analogue peptides effective in such methods. The peptides may mediate their effect by having increased selectivity for the GLP-1 receptor as compared to human glucagon.
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Citations
27 Claims
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1. A compound having the formula R1—
- X—
Z—
R2wherein R1 is hydrogen, C1-4 alkyl, acetyl, formyl, benzoyl or trifluoroacetyl; R2 is OH or NH2; X is a peptide which has the formula I - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27)
- X—
Specification