Benzene sulfonamide thiazole and oxazole compounds

• US 8,642,759 B2
• Filed: 01/31/2013
• Issued: 02/04/2014
• Est. Priority Date: 05/06/2008
• Status: Active Grant

• Current Assignee: Novartis Ag
• Original Assignee: GlaxoSmithKline LLC (GSK plc)
• Inventors: Rheault, Tara Renae
• Primary Examiner(s): Rao, Deepak
• Application Number:
  US13/755,466
• Publication Number:
  US 20130144055A1
• Time in Patent Office: 369 Days
• Field of Search: 544/60, 544/122, 544/295, 544/331, 514/227.8, 514/235.8, 514/252.14, 514/275, 514/256
• US Class Current: 544/331
• CPC Class Codes: A61K 31/427 not condensed and containing further heterocyclic rings
• CPC Class Codes: A61P 35/00 Antineoplastic agents
• CPC Class Codes: A61P 35/02 specific for leukemia
• CPC Class Codes: A61P 35/04 specific for metastasis
• CPC Class Codes: C07D 413/04 directly linked by a ring-member-to-ring-member bond
• CPC Class Codes: C07D 413/14 containing three or more hetero rings
• CPC Class Codes: C07D 417/04 directly linked by a ring-member-to-ring-member bond
• CPC Class Codes: C07D 417/14 containing three or more hetero rings

Abstract

The present invention provides thiazole sulfonamide and oxazole sulfonamide compounds, compositions containing the same, as well as processes for the preparation and methods for their use as pharmaceutical agents.

Claims

1. A compound of formula