Shielded stimulation and sensing system and method

• US 8,644,919 B2
• Filed: 10/06/2009
• Issued: 02/04/2014
• Est. Priority Date: 11/13/2008
• Status: Expired due to Fees

• Current Assignee: Proteus Digital Health, Inc. (Otsuka Holdings Company Limited)
• Original Assignee: Proteus Digital Health, Inc. (Otsuka Holdings Company Limited)
• Inventors: Zdeblick, Mark
• Primary Examiner(s): HINDENBURG, MAX F
• Application Number:
  US12/595,033
• Publication Number:
  US 20110282179A1
• Time in Patent Office: 1,582 Days
• Field of Search: 600/547, 600/372, 600/375, 600/377, 600/393, 607 5- 8
• US Class Current: 600/547
• CPC Class Codes: A61N 1/05 for implantation or insertion into the body, e.g. heart electrode A61N1/06 takes precedence
• CPC Class Codes: A61N 1/0534 Electrodes for deep brain stimulation
• CPC Class Codes: A61N 1/0553 Paddle shaped electrodes, e.g. for laminotomy
• CPC Class Codes: A61N 1/36185 Selection of the electrode configuration

Abstract

Spatial arrays of electrodes are provided, each array in a region of tissue. The electrodes of an array are connected so that some of the electrodes serve as shield electrodes relative to a pair of electrodes used for pulse stimulation or sensing of electrical activity, or both. The shield electrodes are connected together, defining an electrical node, the node defining a stable potential in predetermined relationship with power supply levels or with reference voltages for sensing circuitry. Multiplexing techniques may be employed so that sensed activity at each of several electrode locations can be communicated to electronics external to the electrode locations.

Claims

1. Apparatus for applying an electrical pulse to, or for sensing electrical activity at, a first region of tissue in an animal, the apparatus comprising:

a first array of electrodes disposed upon a respective surface, the first array comprising respective first and second electrodes disposed upon the respective surface, the first array further comprising a plurality of respective third electrodes also disposed upon the respective surface and surrounding the respective first and second electrodes;

wherein the first array of electrodes is electrically selectively connected via a lead to electronics located external to the first array of electrodes, the lead comprising at least one electrical conductor;

the selective connections of the electrodes comprising sensing or driving circuitry connecting the first and second electrodes with the at least one electrical conductor, and further comprising circuitry disposing the third electrodes to serve as an electrical shield for the first and second electrodes through conductive coupling with tissue nearby thereto.

2. The apparatus of claim 1 wherein the selective connections of the electrodes comprises driving circuitry.

3. The apparatus of claim 1 wherein the selective connections of the electrodes comprises sensing circuitry.

4. The apparatus of claim 1 wherein the sensing circuitry comprises a differential amplifier receiving the first and second electrodes as inputs, and providing an output to the at least one electrical conductor, whereby sensed electrical activity is communicated to the electronics external to the array of electrodes.

5. The apparatus of claim 1 wherein the respective surface is substantially planar.

6. The apparatus of claim 1 wherein the respective surface is convex.

7. The apparatus of claim 1 wherein the number of third electrodes is at least six.

8. The apparatus of claim 7 wherein the number of third electrodes is ten.

9. The apparatus of claim 1 wherein the first array receives positive and negative power supplies, and wherein the circuitry selectively connecting the third electrodes to the at least one electrical conductor comprises circuitry biasing the third electrodes at a stable voltage between the positive and negative power supplies.

10. The apparatus of claim 9 wherein the circuitry selectively connecting the third electrodes to the at least one electrical conductor establishes the stable voltage between the positive and negative power supplies at least a diode drop away from either of the power supplies.

11. The apparatus of claim 10 wherein the circuitry selectively connecting the electrodes defines a substrate, and wherein the substrate has a potential, and wherein the circuitry selectively connecting the third electrodes to the at least one electrical conductor further establishes the stable voltage at least two diode drops away from the potential of the substrate.

12. The apparatus of claim 3 wherein the sensed electrical activity as voltage is converted to current, the current thereby carried on the at least one electrical conductor to the electronics, the electronics disposed to measure the current.

13. The apparatus of claim 3 wherein the sensed electrical activity as voltage is converted to a digital signal, the digital signal thereby carried on the at least one electrical conductor to the electronics, the electronics disposed to detect the digital signal.

14. The apparatus of claim 13 wherein the carriage of the digital signal on the at least one electrical conductor is performed by means of an envelope modulation.

15. The apparatus of claim 1 further comprising a second array of electrodes disposed upon a respective surface, the second array comprising respective first and second electrodes disposed upon the respective surface, the second array further comprising a plurality of respective third electrodes also disposed upon the respective surface and surrounding the first and second electrodes;

wherein the second array of electrodes is electrically selectively connected via the lead to the electronics located external to the first array of electrodes, the electronics located external to the first array of electrodes also located external to the second array of electrodes;

the selective connections of the electrodes comprising sensing or driving circuitry connecting the first and second electrodes with the at least one electrical conductor, and further comprising circuitry disposing the third electrodes to serve as an electrical shield for the first and second electrodes through conductive coupling with tissue nearby thereto.