Peripheral nerve field stimulation and spinal cord stimulation

• US 8,644,941 B2
• Filed: 06/09/2006
• Issued: 02/04/2014
• Est. Priority Date: 06/09/2005
• Status: Active Grant

• Current Assignee: Medtronic Incorporated (Medtronic Plc)
• Original Assignee: Medtronic Incorporated (Medtronic Plc)
• Inventors: Rooney, Ethan A., Wahlstrand, Carl D., King, Gary W., Cross, Thomas E. Jr., Evanson, Jeffrey S., Heruth, Kenneth T., Wacnik, Paul W.
• Primary Examiner(s): Heller, Tammie K
• Application Number:
  US11/450,144
• Publication Number:
  US 20070073357A1
• Time in Patent Office: 2,797 Days
• Field of Search: 607/46
• US Class Current: 607/46
• CPC Class Codes: A61N 1/0531 Brain cortex electrodes
• CPC Class Codes: A61N 1/0534 Electrodes for deep brain stimulation
• CPC Class Codes: A61N 1/0553 Paddle shaped electrodes, e.g. for laminotomy
• CPC Class Codes: A61N 1/0558 Anchoring or fixation means therefor
• CPC Class Codes: A61N 1/36021 for treatment of pain
• CPC Class Codes: A61N 1/36071 Pain
• CPC Class Codes: A61N 1/37205 Microstimulators, e.g. implantable through a cannula
• CPC Class Codes: A61N 1/37211 Means for communicating with stimulators
• CPC Class Codes: A61N 1/3756 Casings with electrodes thereon, e.g. leadless stimulators

Abstract

Delivery of peripheral nerve field stimulation (PNFS) in combination with one or more other therapies is described. The other therapy delivered in combination with PNFS may be, for example, a different type of neurostimulation, such as spinal cord stimulation (SCS), or a drug. PNFS and the other therapy may be delivered simultaneously, in an alternating fashion, according to a schedule, and/or selectively, e.g., in response to a request received from a patient or clinician. A combination therapy that includes PNFS may be able to more completely address complex or multifocal pain than would be possible through delivery of either PNFS or other therapies alone. Further, the combination of PNFS with one or more other therapies may reduce the likelihood that neural accommodation will impair the perceived effectiveness PNFS or the other therapies.

Claims

1. A method for treating pain of a patient comprising:

delivering peripheral nerve field stimulation to a specific location of a body of the patient at which the patient experiences pain, wherein delivering peripheral nerve field stimulation comprises delivering peripheral nerve field stimulation via a first set of one or more electrodes implanted in the specific location, and wherein delivering peripheral nerve field stimulation to the specific location does not include directly delivering stimulation to any specific peripheral nerve; and

delivering spinal cord stimulation to the patient via a second set of one or more electrodes implanted in an epidural space proximate to a spinal cord of the patient in combination with the peripheral nerve field stimulation.

2. The method of claim 1, wherein delivering peripheral nerve field stimulation via a first set of electrodes implanted in the specific location comprises delivering peripheral nerve field stimulation via at least one electrode implanted within or between at least one of an intra-dermal, deep dermal, or subcutaneous layer of the specific location.

3. The method of claim 1, wherein delivering peripheral nerve field stimulation and spinal cord stimulation comprises delivering the peripheral nerve field stimulation and the spinal cord stimulation from a single implantable medical device.

4. The method of claim 1, wherein delivering peripheral nerve field stimulation and spinal cord stimulation comprises delivering the peripheral nerve field stimulation and the other therapy simultaneously.

5. The method of claim 1, wherein delivering peripheral nerve field stimulation and spinal cord stimulation comprises alternating delivery of the peripheral nerve field stimulation and the spinal cord stimulation.

6. The method of claim 1, wherein delivering peripheral nerve field stimulation and spinal cord stimulation comprises selectively delivering at least one of the peripheral nerve field stimulation or the spinal cord stimulation based on at least one of a command received from a patient or a schedule.

7. The method of claim 1, wherein delivering peripheral nerve field stimulation in combination with spinal cord stimulation comprises delivering the peripheral nerve field stimulation and the spinal cord stimulation according to at least one of different stimulation parameters or different duty cycles.

8. The method of claim 1, wherein delivering spinal cord stimulation in combination with peripheral nerve field stimulation comprises:

delivering the spinal cord stimulation and the peripheral nerve field stimulation according to different programs within a group of programs that includes a plurality of programs; and

delivering each successive stimulation pulse from an implantable medical device according to a different one of the programs of the group of programs.

9. The method of claim 1, wherein delivering peripheral nerve field stimulation to a specific location of a body of the patient at which a patient experiences pain comprises delivering peripheral nerve field stimulation to specific location of a back of the patient that is laterally displaced from a spinal cord in the back of the patient.

10. The method of claim 9, wherein delivering spinal cord stimulation via a second set of electrodes comprises delivering spinal cord stimulation via at least one electrode implanted within a region from a seventh thoracic vertebrae to a first lumbar vertebrae of the patient.

11. The method of claim 1,

wherein delivering peripheral nerve field stimulation via a first set of electrodes comprises delivering peripheral nerve stimulation via at least one electrode implanted proximate to a branch of a spinal nerve that originates in a region from a second cervical vertebrae to a third cervical vertebrae of the patient, and

wherein delivering spinal cord stimulation via a second set of electrodes comprises delivering spinal cord stimulation via at least one electrode implanted within a region from a first cervical vertebrae to a third cervical vertebrae of the patient.

12. The method of claim 1,

wherein delivering peripheral nerve field stimulation via a first set of electrodes comprises delivering peripheral nerve stimulation via at least one electrode implanted proximate to an eye of the patient, and

wherein delivering spinal cord stimulation via a second set of electrodes comprises delivering spinal cord stimulation via at least one electrode implanted within a region from a first cervical vertebrae to a third cervical vertebrae of the patient.

13. The method of claim 1,

wherein delivering peripheral nerve field stimulation via a first set of electrodes comprises delivering peripheral nerve stimulation via at least one electrode implanted within or between dermal or subcutaneous tissue on a chest of the patient, and

wherein delivering spinal cord stimulation via a second set of electrodes comprises delivering spinal cord stimulation via at least one electrode implanted within a region from a first cervical vertebrae fourth thoracic vertebrae of the patient.

14. The method of claim 1, wherein delivering spinal cord stimulation via a second set of electrodes comprises delivering spinal cord stimulation via the second set of electrodes implanted at least one of in an epidural space or proximal to a dorsal root entry zone.

15. A system for treating pain of a patient comprising:

a first set of one or more electrodes implanted in a specific location of a body of the patient at which the patient experiences pain;

a second set of one or more electrodes implanted in an epidural space proximate to a spinal cord of the patient; and

an implantable medical device coupled to the first and second sets of electrodes that delivers peripheral nerve field stimulation via the first set of electrodes and spinal cord stimulation via the second set of a electrodes, wherein delivering peripheral nerve field stimulation via the first set of one or more electrodes to the specific location does not include directly delivering stimulation to any specific peripheral nerve.

16. The system of claim 15, wherein the first set of electrodes is implanted within or between at least one of an intra-dermal, deep dermal, or subcutaneous layer of the specific location.

17. The system of claim 15, wherein the implantable medical device delivers the peripheral nerve field stimulation and the spinal cord stimulation simultaneously.

18. The system of claim 15, wherein the implantable medical device alternates delivery of the peripheral nerve field stimulation and the spinal cord stimulation.

19. The system of claim 15, wherein the implantable medical device selectively delivers at least one of the peripheral nerve field stimulation or the spinal cord stimulation based on at least one of a command received from a patient or a schedule.

20. The system of claim 15, wherein the implantable medical device delivers the peripheral nerve field stimulation and the spinal cord stimulation according to at least one of different stimulation parameters or duty cycles.

21. The system of claim 15, wherein the implantable medical device delivers stimulation according to a group of programs, the group of programs includes at least one peripheral nerve field stimulation program and at least one spinal cord stimulation program, and the implantable medical device delivers each successive pulse of a plurality of stimulation pulses according to a different one of the programs of the program group.

22. The system of claim 15, wherein the first set of electrodes is implanted in specific location of a back of the patient that is laterally displaced from a spinal cord in the back of the patient.

23. The system of claim 22, wherein the second set of electrodes is implanted within a region from a seventh thoracic vertebrae to a first lumbar vertebrae of the patient.

24. The system of claim 15, wherein the first set of electrodes is implanted proximate to a branch of a spinal nerve that originates in a region from a second cervical vertebrae to a third cervical vertebrae of the patient, and the second set of electrodes is implanted within a region from a first cervical vertebrae to a third cervical vertebrae of the patient.

25. The system of claim 15, wherein the first set of electrodes is implanted proximate to an eye of the patient, and the second set of electrodes implanted within a region from a first cervical vertebrae to a third cervical vertebrae of the patient.

26. The system of claim 15, wherein the first set of electrodes is implanted within or between dermal or subcutaneous tissue on a chest of the patient, and the second set of electrodes is implanted within a region from a first cervical vertebrae fourth thoracic vertebrae of the patient.

27. The system of claim 15, wherein the second set of electrodes is implanted at least one of in an epidural space or proximal to a dorsal root entry zone of the patient.

28. A system for treating pain of a patient comprising:

a first set of one or more electrodes implanted in specific location of a back of the patient that is laterally displaced from a spinal cord in the back of the patient;

a second set of one or more electrodes implanted within a region from a seventh thoracic vertebrae to a first lumbar vertebrae of the patient; and

an implantable medical device coupled to the first and second sets of electrodes that delivers peripheral nerve field stimulation via the first set of electrodes and spinal cord stimulation via the second set of a electrodes, wherein delivering peripheral nerve field stimulation via the first set of one or more electrodes to the specific location does not include directly delivering stimulation to any specific peripheral nerve.

29. The system of claim 28, wherein the first set of electrodes is implanted within or between at least one of an intra-dermal, deep dermal, or subcutaneous layer of the specific location.

30. The system of claim 28, wherein the implantable medical device delivers the peripheral nerve field stimulation and the spinal cord stimulation simultaneously.

31. The system of claim 28, wherein the implantable medical device alternates delivery of the peripheral nerve field stimulation and the spinal cord stimulation.

32. The system of claim 28, wherein the implantable medical device selectively delivers at least one of the peripheral nerve field stimulation or the spinal cord stimulation based on at least one of a command received from a patient or a schedule.

33. The system of claim 28, wherein the implantable medical device delivers the peripheral nerve field stimulation and the spinal cord stimulation according to at least one of different stimulation parameters or duty cycles.

34. The system of claim 28, wherein the implantable medical device delivers stimulation according to a group of programs, the group of programs includes at least one peripheral nerve field stimulation program and at least one spinal cord stimulation program, and the implantable medical device delivers each successive pulse of a plurality of stimulation pulses according to a different one of the programs of the program group.

35. A system for treating pain of a patient comprising:

a first set of one or more electrodes implanted in a specific location of a back of the patient at which the patient experiences pain, wherein the specific location is laterally displaced from a spinal cord in the back of the patient;

a second set of one or more electrodes implanted in an epidural space proximate to a spinal cord of the patient; and

an implantable medical device coupled to the first and second sets of electrodes that delivers peripheral nerve field stimulation via the first set of electrodes and spinal cord stimulation via the second set of a electrodes, wherein delivering peripheral nerve field stimulation via the first set of one or more electrodes to the specific location does not include directly delivering stimulation to any specific peripheral nerve; and

wherein the implantable medical device alternates delivery of the peripheral nerve field stimulation and the spinal cord stimulation, and the implantable medical device delivers peripheral nerve field stimulation according to a peripheral nerve field stimulation program group and spinal cord stimulation according to a spinal cord stimulation program group.