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Methods for delivering a drug to a hospital patient for short-term use while minimizing long-term use of the drug

  • US 8,645,160 B2
  • Filed: 07/03/2012
  • Issued: 02/04/2014
  • Est. Priority Date: 05/16/2008
  • Status: Active Grant
First Claim
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1. A method of treating a subject undergoing abdominal surgery, comprising orally administering to the subject a composition comprising about 12 mg of alvimopan less than one day prior to surgery followed by administering the alvimopan composition to the subject twice daily beginning the day after surgery, wherein the method is carried out in a hospital that has acknowledged that:

  • (i) hospital staff who prescribe, dispense or administer the alvimopan composition have been provided education materials on the need to limit the use of the alvimopan composition to short-term, inpatient use;

    (ii) the subject will not receive more than 15 total doses of the alvimopan composition; and

    (iii) the alvimopan composition will not be dispensed to the subject after being discharged from the hospital.

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