Hydrogel implant for sensing metabolites in body tissue
First Claim
1. An implant for detecting at least one analyte in a body fluid, the implant being designed to be implanted in a body tissue of a patient, the implant comprising a hydrogel matrix with at least one hydrogel and sensor particles dispersed homogeneously in the hydrogel matrix, wherein the sensor particles comprise at least one sensor matrix comprising a sensor matrix material and at least one sensor material, the implant further comprising reference components also dispersed homogeneously in the hydrogel matrix, wherein the reference components are at least substantially analyte-invariant.
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Accused Products
Abstract
An implant (110) for detecting at least one analyte (126) in a body fluid, in particular an eye fluid, is proposed. The implant (110) is designed to be implanted in a tissue layer and/or a chamber of an eye of a patient, the implant (110) having a hydrogel matrix (110) with at least one hydrogel (114). The implant (110) also has sensor particles (116) dispersed in the hydrogel matrix (110), the sensor particles (116) having at least one sensor matrix (120) with a sensor matrix material (122) and at least one sensor material (124).
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Citations
25 Claims
- 1. An implant for detecting at least one analyte in a body fluid, the implant being designed to be implanted in a body tissue of a patient, the implant comprising a hydrogel matrix with at least one hydrogel and sensor particles dispersed homogeneously in the hydrogel matrix, wherein the sensor particles comprise at least one sensor matrix comprising a sensor matrix material and at least one sensor material, the implant further comprising reference components also dispersed homogeneously in the hydrogel matrix, wherein the reference components are at least substantially analyte-invariant.
- 16. An implant for detecting at least one analyte in a body fluid, the implant being designed to be implanted in a body tissue of a patient, the implant comprising a hydrogel matrix with at least one hydrogel and sensor particles dispersed in the hydrogel matrix, wherein the sensor particles comprise at least one sensor matrix comprising a sensor matrix material and at least one sensor material, wherein the at least one sensor material has a higher diffusion coefficient in the sensor matrix material than in the hydrogel matrix.
- 18. An implant for detecting at least one analyte in a body fluid, the implant being designed to be implanted in a body tissue of a patient, the implant comprising a hydrogel matrix with at least one hydrogel and sensor particles dispersed in the hydrogel matrix, wherein the sensor particles comprise at least one sensor matrix comprising a sensor matrix material and at least one sensor material, wherein the sensor matrix material comprises a hydrogel with a water content that exceeds the water content of the hydrogel of the hydrogel matrix.
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20. An implant for detecting at least one analyte in a body fluid, the implant being designed to be implanted in a body tissue of a patient, the implant comprising hydrogel matrix with at least one hydrogel and sensor particles dispersed in the hydrogel matrix, wherein the sensor particles comprise at least one sensor matrix comprising a sensor matrix material and at least one sensor material, wherein the hydrogel matrix and the sensor matrix material comprise a chemically identical hydrogel, wherein the hydrogel of the hydrogel matrix has a higher degree of crosslinking than the hydrogel of the sensor matrix material.
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21. An implant for detecting at least one analyte in a body fluid, the implant being designed to be implanted in a body tissue of a patient, the implant comprising as hydrogel matrix with at least one hydrogel and sensor particles dispersed homogeneously in the hydrogel matrix, wherein the sensor particles comprise at least one sensor matrix comprising a sensor matrix material and at least one sensor material, wherein the implant has a shaped hydrogel article, the shaped hydrogel article having a substantially fiat, round configuration, the diameter of the shaped hydrogel article being not greater than 10 mm, and wherein the shaped hydrogel article has a surface-volume ratio of at least 5.
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22. An implant for detecting at least one analyte in a body fluid, the implant being designed to be implanted in a body tissue of a patient, the implant comprising a hydrogel matrix with at least one hydrogel and sensor particles dispersed homogeneously in the hydrogel matrix, wherein the sensor particles comprise at least one sensor matrix comprising a sensor matrix material and at least one sensor material, wherein the implant has a shaped hydrogel article, the shaped article having a substantially right-angled edge.
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23. An implant for detecting at least one analyte in a body fluid, the implant being designed to be implanted in a body tissue of a patient, the implant comprising a hydrogel matrix with at least one hydrogel and sensor particles dispersed homogeneously in the hydrogel matrix, wherein the sensor particles comprise at least one sensor matrix comprising a sensor matrix material and at least one sensor material, wherein the implant has a shaped hydrogel article, the shaped hydrogel article having a substantially flat, round configuration, the diameter of the shaped hydrogel article being not greater than 10 mm, wherein the shaped article has a curve with a radius of curvature of between 5 mm and 20 mm.
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24. An implant for detecting at least one analyte in a body fluid, the implant being designed to be implanted in a body tissue of a patient, the implant comprising a hydrogel matrix with at least one hydrogel. and sensor particles dispersed homogeneously in the hydrogel matrix, wherein the sensor particles comprise at least one sensor matrix comprising a sensor matrix material and at least one sensor material, wherein the implant has a shaped hydrogel article, the shaped hydrogel article having a substantially flat, round configuration, the diameter of the shaped hydrogel article being not greater than 10 mm, wherein the edge area of the shaped article has a thickness of not more than 250 micrometers.
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25. An implant for detecting at least one analyte in a body fluid, the implant being designed to be implanted in a body tissue of a patient, the implant comprising a hydrogel matrix with at least one hydrogel and sensor particles dispersed homogeneously in the hydrogel matrix, wherein the sensor particles comprise at least one sensor matrix comprising a sensor matrix material and at least one sensor material, wherein the implant has a shaped hydrogel article, the shaped hydrogel article having a substantially flat, round configuration, the diameter of the shaped hydrogel article being not greater than 10 mm, wherein the shaped article has a rounded edge.
Specification