System and method for optimized apheresis draw and return

• US 8,647,289 B2
• Filed: 03/31/2011
• Issued: 02/11/2014
• Est. Priority Date: 04/14/2008
• Status: Active Grant

• Current Assignee: Haemonetics Corporation
• Original Assignee: Haemonetics Corporation
• Inventors: Pags, Etienne, Ragusa, Michael
• Primary Examiner(s): MARCETICH, ADAM M
• Application Number:
  US13/076,882
• Publication Number:
  US 20110178453A1
• Time in Patent Office: 1,048 Days
• Field of Search: 604/4.01, 604/5, 604/6.01, 604/1, 604/6.04, 604/6.05, 604/6.07, 604/6.1, 604/6.11, 604/505, 604/506, 604/507, 604/66, 604/67, 604/118, 604/119, 604/5.01, 422/44
• US Class Current: 604/6.04
• CPC Class Codes: A61M 1/024 Means for controlling the quantity of transfused blood, e.g. by weighing the container and automatic stopping of the transfusion after reaching a determined amount
• CPC Class Codes: A61M 1/0245 combined with blood container shaking means
• CPC Class Codes: A61M 1/14 Dialysis systems; Artificial kidneys; Blood oxygenators semi-permeable membranes characterised by the material, manufacturing processes therefor B01D71/00 ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
• CPC Class Codes: A61M 1/1601 Control or regulation
• CPC Class Codes: A61M 1/1603 Regulation parameters
• CPC Class Codes: A61M 1/1613 Profiling or modelling of patient or predicted treatment evolution or outcome
• CPC Class Codes: A61M 1/30 Single needle dialysis ; Reciprocating systems, alternately withdrawing blood from and returning it to the patient, e.g. single-lumen-needle dialysis or single needle systems for hemofiltration or pheresis
• CPC Class Codes: A61M 1/3472 with treatment of the filtrate
• CPC Class Codes: A61M 1/36 Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
• CPC Class Codes: A61M 1/3607 Regulation parameters
• CPC Class Codes: A61M 1/3621 Extra-corporeal blood circuits single-needle circuits A61M1/30
• CPC Class Codes: A61M 1/3639 Blood pressure control, pressure transducers specially adapted therefor
• CPC Class Codes: A61M 1/3663 Flow rate transducers; Flow integrators
• CPC Class Codes: A61M 1/3679 by absorption A61M1/3675 takes precedence
• CPC Class Codes: A61M 1/382 Optimisation of blood component yield
• CPC Class Codes: A61M 2205/3306 Optical measuring means
• CPC Class Codes: A61M 2205/3331 Pressure; Flow
• CPC Class Codes: A61M 2205/3334 Measuring or controlling the flow rate
• CPC Class Codes: A61M 2205/3344 Measuring or controlling pressure at the body treatment site
• CPC Class Codes: A61M 2205/3351 Controlling upstream pump pressure
• CPC Class Codes: A61M 2205/3355 : Controlling downstream pump pressure
• CPC Class Codes: A61M 2205/3379 : Masses, volumes, levels of fluids in reservoirs, flow rates
• CPC Class Codes: A61M 2205/3393 : by weighing the reservoir

Abstract

A blood processing device includes a venous-access device, a blood component separation device, a return line, a draw line, a first pressure sensor, a second pressure sensor, and a first pump. The first pressure sensor is located on the return line between the blood component separation device and the venous-access device, and determines a first pressure. The second pressure sensor is located on the draw line between the blood component separation device and the venous-access device, and determines a second pressure. The first pump is connected to at least one of the return line and the draw line and controls a flow rate within the connected line based on a subject access pressure determined based upon the first and second pressures.

Claims

1. A blood processing device for collecting and exchanging blood components, the blood processing device comprising:

a venous-access device for drawing whole blood from a subject and returning unused blood components to the subject;

a blood component separation device for separating the drawn whole blood into a first blood component and a second blood component, the blood component separation device configured to send the second blood component to a second blood component storage container;

a draw/return line fluidly connecting the venous-access device and the blood component separation device for drawing whole blood from a subject and returning the first blood component to the subject;

a first pressure sensor located on the draw/return line between the blood component separation device and the venous-access device for determining a first pressure within the draw/return line;

a second pressure sensor located on the draw/return line between the first pressure sensor and the venous-access device for determining a second pressure within the draw/return line; and

a pump connected to the draw/return line for controlling a flow rate within the draw/return line, the pump controlling the flow rate based on a subject access pressure determined based on the first pressure and the second pressure.

2. A blood processing system according to claim 1, wherein the venous access device may also be used for returning compensation fluid to the subject.

3. A blood processing system according to claim 1, wherein the blood component separation device is a centrifuge bowl.

4. A blood processing system according to claim 1, further comprising an anticoagulation line for introducing anticoagulant into the drawn blood near the venous-access device.

5. A blood processing system according to claim 1 further including a valve located on the draw/return line between the blood component separation device and the venous-access device, the valve stopping the flow within the draw/return line.

6. A blood processing device according to claim 1, wherein the subject access pressure is further based on at least one characteristic of a first portion of the draw/return line and at least one characteristic of a second portion of the draw/return line, wherein the first portion is between the second pressure sensor and the venous-access device and the second portion is between the first and second pressure sensors.

7. A blood processing device according to claim 6, wherein the at least one characteristic of the first portion of the draw/return line and the at least one characteristic of the second portion of the draw/return line are selected from the group consisting of length, inner diameter, and materials of construction.

8. A blood processing device according to claim 6, wherein the flow rate is also controlled based on a first flow resistance within the first portion of the draw/return line, the first flow resistance calculated based on the at least one characteristic of the first portion of the draw/return line.

9. A blood processing device according to claim 8, wherein the flow rate is further controlled based on a second flow resistance within the second portion of the draw/return line, the second flow resistance calculated based on the at least one characteristic of the second portion of the draw/return line.

10. A blood processing device according to claim 1, wherein the blood component separation device further separates the drawn blood into a third blood component in addition to the first blood component and the second blood component.

11. A blood processing device according to claim 10, wherein the first blood component is red blood cells, the second blood component is platelets, and the third blood component is plasma.

12. A blood processing device according to claim 1, wherein the subject access pressure is determined in real-time.

13. A blood processing device according to claim 1, wherein the flow rate is at least one of a draw flow rate and a return flow rate.

14. A blood processing device according to claim 1, wherein the first and second pressure sensors are located between the pump and the venous access device.