Microfabricated artificial lung assist device, and methods of use and manufacture thereof
First Claim
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1. An extracorporeal membrane oxygenator device, comprising a plurality of bi-layer structures arranged in a stack, each bi-layer structure comprising:
- (i) a first micropatterned polymer layer defining a plurality of blood flow channels therethrough;
(ii) a second micropatterned polymer layer defining a plurality of gas channels running substantially parallel to and overlapping the plurality of blood flow channels, wherein a width of each of the plurality of gas channels spans a width of at least ten of the blood flow channels of the plurality of blood flow channels; and
(iii) a gas-permeable polymer membrane located between and bonding the first micropatterned polymer layer to the second micropatterned polymer layer.
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Abstract
The invention provides systems and methods for exchanging gas in an oxygenator device, and methods for preparing and using such oxygenator devices. The systems and methods can be used to transfer oxygen to blood to assist lung function in a patient.
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22 Claims
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1. An extracorporeal membrane oxygenator device, comprising a plurality of bi-layer structures arranged in a stack, each bi-layer structure comprising:
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(i) a first micropatterned polymer layer defining a plurality of blood flow channels therethrough; (ii) a second micropatterned polymer layer defining a plurality of gas channels running substantially parallel to and overlapping the plurality of blood flow channels, wherein a width of each of the plurality of gas channels spans a width of at least ten of the blood flow channels of the plurality of blood flow channels; and (iii) a gas-permeable polymer membrane located between and bonding the first micropatterned polymer layer to the second micropatterned polymer layer. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22)
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Specification