Methods for modulating inflammatory and/or immune responses
First Claim
1. A method for down-regulating an autoimmune response in a subject with an autoimmune disease, the method comprising the step of contacting the subject'"'"'s Peripheral Blood Mononuclear Cell (PBMC) population with a purified population of CD 117-negative Amnion-derived Multipotent Progenitor (AMP) cells such that the AMP cells inhibit the differentiation of monocytes in the PBMC population into mature dendritic cells, resulting in the down-regulation of the autoimmune response in the subject.
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Abstract
The invention is directed to novel methods for modulating inflammatory and/or immune responses. Such methods utilize compositions comprising extraembryonic cells (herein referred to as EE cells) including but not limited to extraembryonic HLA-G positive cells (herein referred to as EHP cells) and amnion-derived multipotent progenitor cells (herein referred to as AMP cells); compositions comprising expanded EE cell populations, and/or cell lysates and/or conditioned media derived therefrom, alone or in combination with each other and/or in combination with various extracellular matrices and/or devices and/or other suitable active agents.
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4 Claims
- 1. A method for down-regulating an autoimmune response in a subject with an autoimmune disease, the method comprising the step of contacting the subject'"'"'s Peripheral Blood Mononuclear Cell (PBMC) population with a purified population of CD 117-negative Amnion-derived Multipotent Progenitor (AMP) cells such that the AMP cells inhibit the differentiation of monocytes in the PBMC population into mature dendritic cells, resulting in the down-regulation of the autoimmune response in the subject.
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