Biocompatible polyacrylate compositions for medical applications

• US 8,647,655 B2
• Filed: 06/18/2010
• Issued: 02/11/2014
• Est. Priority Date: 12/11/2002
• Status: Expired due to Fees

• Current Assignee: Abbott Cardiovascular Systems Incorporated (Abbott Laboratories Incorporated)
• Original Assignee: Abbott Cardiovascular Systems Incorporated (Abbott Laboratories Incorporated)
• Inventors: Hossainy, Syed F. A.
• Primary Examiner(s): PURDY, KYLE A
• Application Number:
  US12/819,128
• Publication Number:
  US 20100255058A1
• Time in Patent Office: 1,334 Days
• Field of Search: None
• US Class Current: 424/423
• CPC Class Codes: A61K 31/445 Non condensed piperidines, e.g. piperocaine
• CPC Class Codes: A61K 31/74 Synthetic polymeric materials
• CPC Class Codes: A61L 31/10 Macromolecular materials
• CPC Class Codes: A61L 31/16 Biologically active materials, e.g. therapeutic substances A61L31/047 takes precedence
• CPC Class Codes: A61P 41/00 Drugs used in surgical methods, e.g. surgery adjuvants for preventing adhesion or for vitreum substitution
• CPC Class Codes: A61P 9/10 for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
• CPC Class Codes: C08L 33/06 of esters containing only carbon, hydrogen and oxygen, which oxygen atoms are present only as part of the carboxyl radical

Abstract

A composition comprising a structural component comprising linear acrylic homopolymers or linear acrylic copolymers and a biobeneficial component comprising copolymers having an acrylate moiety and a biobeneficial moiety is disclosed. A medical article comprising the composition in the coating thereof and a method of fabricating the medical article are also disclosed.

Claims

1. A medical article comprising an implantable medical device and a coating deposited on at least a part of the device, the coating comprising:

(a) a structural component comprising a linear acrylic homopolymer or linear acrylic copolymer; and

(b) a biobeneficial component comprising a copolymer having an acrylate moiety and a biobeneficial moiety;

wherein the copolymer composing the biobeneficial component has the formula;

2. The medical article of claim 1, wherein the medical device is a stent.

3. The medical article of claim 1, wherein the mass ratio between the structural component and the biobeneficial component is between about 99:

1 and about 1;

1.

4. The medical article of claim 1, wherein the acrylic homopolymer or linear acrylic copolymer has the structure:

5. The medical article of claim 1, wherein Q is derived from poly(alkylene glycols), superoxide dismutate-mimetics (SODm), diazenium diolate type nitric oxide donors, polycationic peptides, polysaccharides, pyrrolidone, vitamin E, sulfonated dextrane, β

-phenoxyethanol, N,N-dimethylamino-2-ethanol, mannose-6-phosphate, sulfonic acid, derivatives of sulfonic acid, or mixtures thereof.

6. The medical article of claim 5, wherein the polycationic peptides are poly(L-arginine), poly(D-arginine), poly(D,L-arginine), poly(L-lysine), poly(D-lysine), poly(δ

-guanidino-α

-aminobutyric acid), a racemic mixture of poly(L-arginine) or poly(D-arginine), or mixtures thereof.

7. The medical article of claim 5, wherein the polysaccharides are heparin or derivatives thereof, glycosaminoglycans, keratan sulfate, chondroitin sulfate, dermatan sulfate, hyaluronic acid, hyaluronates, or mixtures thereof.

8. The medical article of claim 5, wherein the derivatives of heparin are heparinoids, heparin having a hydrophobic counterion, heparan sulfate, heparin salts, or mixtures thereof.

9. The medical article of claim 5, wherein the derivatives of sulfonic acid are propanesulfonic acid, 2-methyl-1-propanesulfonic acid, benzenesulfonic acid, 3-methoxy-2-hydroxypropanesulfonic acid, or mixtures thereof.