Electrochemical biosensors and arrays
First Claim
1. An amperometric sensor device comprising:
- a structural body which comprises a first plurality of reservoirs, each of the first plurality of reservoirs having at least one opening in the structural body and a working electrode located in said reservoir;
analyte sensor chemistry located within each of the first plurality of reservoirs and deposited on at least the working electrode;
one or more auxiliary electrodes located on the structural body outside of the first plurality of reservoirs and a reference electrode located inside each reservoir, or one or more auxiliary electrodes located on the structural body outside of the first plurality of reservoirs and one or more reference electrodes located outside of the first plurality of reservoirs;
at least one reservoir cap closing the at least one opening of each of the first plurality of reservoirs to isolate the working electrode and analyte sensor chemistry within the reservoir from an analyte outside of the reservoir to prevent contact with the analyte sensor chemistry; and
means for rupturing or displacing each reservoir cap independently to permit the analyte from outside of the reservoir to contact the analyte sensor chemistry,wherein the one or more reference electrodes, the one or more auxiliary electrodes, or both, are adapted to be operatively coupled with two or more of the working electrodes.
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Accused Products
Abstract
Electrochemical sensor devices are provided, in various amperometric, potentiometric, and conductometric sensor device configurations. An amperometric sensor device may include a structural body which has at least one reservoir that has at least one opening; a working electrode located within the reservoir; analyte sensor chemistry located within the reservoir and deposited on at least the working electrode; an auxiliary electrode located outside of the reservoir; a reference electrode; at least one reservoir cap closing the opening to isolate the working electrode and analyte sensor chemistry within the reservoir and to prevent an analyte outside of the reservoir from contacting the analyte sensor chemistry; and means for rupturing or displacing the reservoir cap to permit the analyte from outside of the reservoir to contact the analyte sensor chemistry.
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Citations
25 Claims
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1. An amperometric sensor device comprising:
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a structural body which comprises a first plurality of reservoirs, each of the first plurality of reservoirs having at least one opening in the structural body and a working electrode located in said reservoir; analyte sensor chemistry located within each of the first plurality of reservoirs and deposited on at least the working electrode; one or more auxiliary electrodes located on the structural body outside of the first plurality of reservoirs and a reference electrode located inside each reservoir, or one or more auxiliary electrodes located on the structural body outside of the first plurality of reservoirs and one or more reference electrodes located outside of the first plurality of reservoirs; at least one reservoir cap closing the at least one opening of each of the first plurality of reservoirs to isolate the working electrode and analyte sensor chemistry within the reservoir from an analyte outside of the reservoir to prevent contact with the analyte sensor chemistry; and means for rupturing or displacing each reservoir cap independently to permit the analyte from outside of the reservoir to contact the analyte sensor chemistry, wherein the one or more reference electrodes, the one or more auxiliary electrodes, or both, are adapted to be operatively coupled with two or more of the working electrodes. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12)
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13. A potentiometric sensor device comprising:
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a structural body which comprises a plurality of reservoirs that each have at least one opening in the structural body; at least one indicator electrode located within a first reservoir of the plurality of reservoirs; at least one reference electrode located within a second reservoir of the plurality of reservoirs, wherein the first reservoir is different from the second reservoir and the at least one indicator electrode and the at least one reference electrode forms an operable pair of electrodes; at least one reservoir cap closing the at least one opening of each of the plurality of reservoirs, to isolate the at least one indicator electrode and the at least one reference electrode within the first and second reservoirs and to prevent an analyte outside of the first and second reservoirs from contacting the at least one indicator electrode and the at least one reference electrode; and means for rupturing or displacing the reservoir caps independently to permit the analyte from outside of the reservoir to contact the at least one indicator electrode and the at least one reference electrode, wherein an electrical potential which can be developed between the at least one indicator electrode and the at least one reference electrode provides a sensor signal indicative of a concentration of the analyte. - View Dependent Claims (14, 15)
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16. A potentiometric sensor device comprising:
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a structural body which comprises a first plurality of reservoirs that each have at least one opening in the structural body; at least one indicator electrode located within each of the first plurality of reservoirs; at least one reference electrode located outside of the first plurality of reservoirs; at least one reservoir cap corresponding to and closing each of the at least one opening of each of the first plurality of reservoirs, to isolate the at least one indicator electrode within each of the plurality of reservoirs from an analyte outside of the reservoir to prevent contacting the at least one indicator electrode; and means for rupturing or displacing each of the at least one reservoir cap independently to permit the analyte from outside of the reservoir to contact the at least one indicator electrode, wherein a potential which can be developed between the at least one indicator electrode and the at least one reference electrode provides a sensor signal indicative of a concentration of the analyte. - View Dependent Claims (17, 18, 25)
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19. A conductometric sensor device comprising:
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a structural body which comprises a plurality of reservoirs that each have at least one opening in the structural body; an electrode pair located within each reservoir, each electrode pair being co-planar and having an interdigitated or serpentine configuration and at least one reference electrode located outside of the plurality of reservoirs; a biological recognition element or other selectively sensitive material located within each reservoir and deposited on the electrode pair; at least one reservoir cap closing the at least one opening of each reservoir to isolate the electrode pair and the biological recognition element within the reservoir from an analyte outside of the reservoir and to prevent contacting the biological recognition element; and means for rupturing or displacing each reservoir cap independently to permit the analyte from outside of the reservoir to contact the corresponding biological recognition element. - View Dependent Claims (20, 21, 22, 23, 24)
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Specification