Burst suppression monitor for induced coma
First Claim
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1. A method of monitoring a sedated subject using a logic processor in a monitoring system comprising:
- receiving digital data representing said subject'"'"'s EEG signal at said processor;
using said processor to determine one or more burst onsets;
using said processor to determine one or more suppression onsets;
using said processor to determine one or more interburst or burst suppression intervals by comparing one or more burst onsets to one or more previous suppression onsets;
using said processor to determine a true interburst interval or true mean burst suppression (BS) interval for a specified time length with statistical confidence wherein said mean burst suppression interval indicates time between burst onsets and previous suppression onsets, regardless of burst duration;
using said mean burst suppression interval to inform therapy for said subject to maintain said desired state of sedation;
calculating an absolute amplitude difference across said EEG signal, with an absolute amplitude difference history interval;
smoothing said absolute amplitude difference to minimizes effects of signal variation on onset detection; and
detecting burst onset when an absolute smoothed amplitude difference exceeds a median absolute amplitude times a specified multiplication factor.
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Abstract
Methods and systems for monitoring subjects, analyzing EEG data, and maintaining subjects at desired sedation states.
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Citations
23 Claims
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1. A method of monitoring a sedated subject using a logic processor in a monitoring system comprising:
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receiving digital data representing said subject'"'"'s EEG signal at said processor; using said processor to determine one or more burst onsets; using said processor to determine one or more suppression onsets; using said processor to determine one or more interburst or burst suppression intervals by comparing one or more burst onsets to one or more previous suppression onsets; using said processor to determine a true interburst interval or true mean burst suppression (BS) interval for a specified time length with statistical confidence wherein said mean burst suppression interval indicates time between burst onsets and previous suppression onsets, regardless of burst duration; using said mean burst suppression interval to inform therapy for said subject to maintain said desired state of sedation; calculating an absolute amplitude difference across said EEG signal, with an absolute amplitude difference history interval; smoothing said absolute amplitude difference to minimizes effects of signal variation on onset detection; and detecting burst onset when an absolute smoothed amplitude difference exceeds a median absolute amplitude times a specified multiplication factor. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23)
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Specification