Systems for remote generation of electrical signal in tissue based on time-reversal acoustics

• US 8,649,875 B2
• Filed: 04/17/2012
• Issued: 02/11/2014
• Est. Priority Date: 09/10/2005
• Status: Expired due to Fees

• Current Assignee: Artann Laboratories Inc.
• Original Assignee: Artann Laboratories Inc.
• Inventors: Sarvazyan, Armen P.
• Primary Examiner(s): Koharski, Christopher
• Assistant Examiner(s): KIMBALL, JEREMIAH T
• Application Number:
  US13/448,530
• Publication Number:
  US 20120203306A1
• Time in Patent Office: 665 Days
• Field of Search: 607/2, 607/32, 607/60, 607/437
• US Class Current: 607/60
• CPC Class Codes: A61B 2017/00411 actuated by application of energy from an energy source outside the body
• CPC Class Codes: A61B 2017/3413 guided by ultrasound
• CPC Class Codes: A61B 2034/2063 Acoustic tracking systems, e.g. using ultrasound
• CPC Class Codes: A61B 2090/3782 transmitter or receiver in catheter or minimal invasive instrument
• CPC Class Codes: A61B 2090/3929 Active markers
• CPC Class Codes: A61B 34/20 Surgical navigation systems; Devices for tracking or guiding surgical instruments, e.g. for frameless stereotaxis
• CPC Class Codes: A61B 5/061 Determining position of a probe within the body employing means separate from the probe, e.g. sensing internal probe position employing impedance electrodes on the surface of the body A61B1/00158 takes precedence
• CPC Class Codes: A61B 5/4839 combined with drug delivery
• CPC Class Codes: A61B 5/7203 for noise prevention, reduction or removal
• CPC Class Codes: A61B 8/0841 for locating instruments
• CPC Class Codes: A61B 8/12 in body cavities or body tracts, e.g. by using catheters catheters per se A61M25/00
• CPC Class Codes: A61B 90/39 Markers, e.g. radio-opaque or breast lesions markers
• CPC Class Codes: A61M 37/0092 using ultrasonic, sonic or infrasonic vibrations, e.g. phonophoresis
• CPC Class Codes: A61N 1/36062 Spinal stimulation
• CPC Class Codes: A61N 1/37217 characterised by the communication link, e.g. acoustic or tactile
• CPC Class Codes: A61N 1/3756 Casings with electrodes thereon, e.g. leadless stimulators
• CPC Class Codes: A61N 1/3787 from an external energy source

Abstract

A time-reversal acoustics system includes a transmitter configured to send a high intensity acoustic waveform signal focused on an implantable receiver. The receiver includes a piezoelectric transducer configured to convert received acoustic energy to an electrical signal used to energize an internal electrical circuit. Such circuit may be used to operate at least one tissue stimulating electrode, at least one sensor such as an ECG sensor, charge an internal battery or perform another useful function. The system of the invention may be used as a wireless cardiac pacemaker or a neurostimulator.

Claims

1. A time-reversal acoustics system for remote generation of electrical signal in tissue, the system comprising:

a first receiver including in a hermetically sealed housing;

a first piezoelectric receiving transducer,

an internal electrical circuit with an input operably coupled to said first receiving transducer,

a first antenna configured for emitting a first radiofrequency signal, said first antenna operably coupled to said first receiving transducer,

a first stimulating electrode operably coupled to an output of said internal electrical circuit, said first stimulating electrode is configured to be engaged with the tissue, and

a transmitter including;

a time-reversal electronic unit,

a radiofrequency signal receiver with an input operably coupled with a radiofrequency antenna and an output operably coupled with an input of said time-reversal electronic unit,

an emitting acoustic transducer with an input operably coupled to an output of said time-reversal electronic unit,

wherein said time-reversal electronic unit is configured to provide said emitting acoustic transducer with a driving signal formed by time-reversing of the radiofrequency signal received from said first receiver in response to an acoustic wave signal generated by said emitting acoustic transducer;

said driving signal causing said emitting acoustic transducer to send a high intensity acoustic wave signal focused on said first piezoelectric receiving transducer to generate electrical energy sufficient to operate said first stimulating electrode to generate said electrical signal in the tissue.

2. The time-reversal acoustics system as in claim 1, wherein said transmitter is enclosed in a hermetically sealed housing and configured for implantation inside the patient.

3. The time-reversal acoustics system as in claim 2, wherein said transmitter is battery-powered.

4. The time-reversal acoustics system as in claim 2, wherein said system further includes an outside control console configured to communicate with said transmitter to send control signals thereto.

5. The time-reversal acoustics system as in claim 1, wherein said transmitter is configured to be externally placed in contact with the patient.

6. The time-reversal acoustics system as in claim 1, wherein said transmitter includes a reverberator.

7. The time-reversal acoustics system as in claim 6, wherein said transmitter includes a plurality of emitting transducers mounted inside said reverberator.

8. The time-reversal acoustics system as in claim 1, wherein said system includes additional receivers, each of the additional receivers including at least one respective receiving piezoelectric transducer and at least one corresponding antenna operably coupled thereto and configured for emitting radiofrequency signals.

9. The time-reversal acoustics system as in claim 1, wherein said receiver includes a plurality of stimulating electrodes operably coupled with said internal electrical circuit.

10. The time-reversal acoustics system as in claim 1, wherein said receiver includes a plurality of piezoelectric receiving transducers, each said receiving piezoelectric transducer is operably coupled to a respective antenna configured for emitting radiofrequency signals.

11. The time-reversal acoustics system as in claim 1, wherein said receiver includes at least one sensor.

12. The time-reversal acoustics system as in claim 11, wherein said sensor is selected from a group of sensors consisting of an ECG or other electrical activity sensor;

a motion detector;

a local, core body or other temperature sensor;

a pressure sensor;

an impedance sensor;

a sensor to indicate rejection of a transplanted organ;

a heart rhythm sensor;

a force sensor;

a chemical substance detector; and

a sensor indicating remaining electrical charge level for an internal battery.

13. The time-reversal acoustic system as in claim 1, wherein said receiver and said transmitter are further configured to perform together a function of tissue stimulation, said function of tissue stimulation is selected from a group consisting of a cardiac stimulator, a pacemaker, a cardiac defibrillator, and a neurostimulator.