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Methods of making small volume in vitro analyte sensors

  • US 8,650,751 B2
  • Filed: 09/29/2009
  • Issued: 02/18/2014
  • Est. Priority Date: 10/08/1998
  • Status: Expired due to Fees
First Claim
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1. A method of manufacturing a plurality of electrochemical sensors, the method comprising the steps of:

  • forming a plurality of individual working electrodes on a first electrode region of a first substrate;

    forming a plurality of individual counter electrodes on a second electrode region of a second substrate;

    positioning a spacer layer comprising a release liner on one of the first and the second electrode regions;

    following positioning of the spacer layer, removing the release liner to remove a portion of the spacer layer to define sample chamber regions;

    overlaying the first substrate with the second substrate to form a layered structure; and

    separating the layered structure into a plurality of electrochemical sensors, each electrochemical sensor comprising at least one working electrode, at least one counter electrode, and at least one sample chamber region.

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