Bead-containing dry powder inhaler
First Claim
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1. A dry powder inhaler, comprising:
- an inlet channel through which air enters the inhaler;
a chamber that receives air from the inlet channel, wherein the chamber has a longitudinal axis, and wherein the inlet channel is generally co-axial with the longitudinal axis;
a single bead-like actuator disposed within the chamber, wherein the bead-like actuator has an outer surface to which a medicament is adhered; and
an outlet channel through which air and the powdered medicament leave the inhaler to be delivered to a patient, wherein the outlet channel is generally co-axial with the longitudinal axis of the chamber;
wherein the geometry of the inhaler is such that a flow profile is generated within the chamber that causes the bead-like actuator to oscillate generally co-axial with the longitudinal axis, thus detaching the medicament from the outer surface of the bead-like actuator to be entrained by the air and delivered to the patient through the outlet channel.
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Abstract
A dry powder inhaler includes a chamber holding a bead-like actuator to which a powdered medicament is adhered. Air is drawn into the chamber through an inlet flow channel and exits through an outlet flow channel. The bead-like actuator oscillates in response to the air flow, dislodging powdered medicament to be entrained in the air flow and delivered to the patient.
182 Citations
18 Claims
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1. A dry powder inhaler, comprising:
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an inlet channel through which air enters the inhaler; a chamber that receives air from the inlet channel, wherein the chamber has a longitudinal axis, and wherein the inlet channel is generally co-axial with the longitudinal axis; a single bead-like actuator disposed within the chamber, wherein the bead-like actuator has an outer surface to which a medicament is adhered; and an outlet channel through which air and the powdered medicament leave the inhaler to be delivered to a patient, wherein the outlet channel is generally co-axial with the longitudinal axis of the chamber; wherein the geometry of the inhaler is such that a flow profile is generated within the chamber that causes the bead-like actuator to oscillate generally co-axial with the longitudinal axis, thus detaching the medicament from the outer surface of the bead-like actuator to be entrained by the air and delivered to the patient through the outlet channel. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11)
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12. A method, comprising:
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obtaining a dry power inhaler that includes an inlet channel, a chamber, and an outlet channel, the chamber holding a single bead-like actuator, wherein one or more powdered medicaments are adhered to an outside surface of the bead-like actuator; and inhaling through the outlet channel, causing air to flow into the inlet channel, through the chamber, and through the outlet chamber, the flowing air also causing the bead-like actuator to oscillate generally along a longitudinal axis extending between the inlet channel and the outlet channel to dislodge powdered medicament from the surface of the bead-like actuator to be entrained in the flowing air and carried through the outlet channel. - View Dependent Claims (13, 14, 15, 16, 17)
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18. A dry powder inhaler, comprising:
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an inlet channel through which air enters the inhaler; a chamber that receives air from the inlet channel, wherein the chamber has a longitudinal axis; a single bead-like actuator disposed within the chamber, wherein the bead-like actuator has an outer surface to which at least one medicament is adhered; and an outlet channel through which air and the powdered medicament leave the inhaler to be delivered to a patient, wherein the inlet chamber and the outlet chamber are aligned with the longitudinal axis; wherein the geometry of the inlet and the chamber, and the mass of the bead-like actuator, are configured such that the bead-like actuator oscillates at a desired frequency and amplitude within the chamber when fluid flows through the chamber in order to detach the medicament from the outer surface of the bead-like actuator to be delivered to the patient through the outlet channel.
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Specification