Implantation device for metabolite sensors

• US 8,652,101 B2
• Filed: 10/02/2009
• Issued: 02/18/2014
• Est. Priority Date: 10/02/2008
• Status: Active Grant

• Current Assignee: EyeSense AG
• Original Assignee: EyeSense AG
• Inventors: Mller, Achim, Herbrechtsmeier, Peter
• Primary Examiner(s): FLICK, JASON E
• Application Number:
  US13/122,110
• Publication Number:
  US 20110230835A1
• Time in Patent Office: 1,600 Days
• Field of Search: 604/150
• US Class Current: 604/150
• CPC Class Codes: A61B 17/3468 for implanting or removing devices, e.g. prostheses, implants, seeds, wires devices for implanting seeds A61M37/0069
• CPC Class Codes: A61B 2017/00535 pneumatically or hydraulically operated A61B2017/22051, A61B2090/401 take precedence
• CPC Class Codes: A61B 2017/00539 hydraulically
• CPC Class Codes: A61B 2017/3447 Linked multiple cannulas
• CPC Class Codes: A61B 5/0071 by measuring fluorescence emission
• CPC Class Codes: A61B 5/0075 by spectroscopy, i.e. measuring spectra, e.g. Raman spectroscopy, infrared absorption spectroscopy A61B5/0071 takes precedence
• CPC Class Codes: A61B 5/0084 for introduction into the body, e.g. by catheters A61B5/1459 takes precedence
• CPC Class Codes: A61B 5/14532 for measuring glucose, e.g. by tissue impedance measurement

Abstract

The invention relates to an implantation device for implanting a sensor element for detecting at least one analyte in a bodily fluid or body tissue. The implantation device comprises at least one cannula for piercing a skin surface of a patient. The cannula has at least one holding area for holding the sensor element. The implantation device furthermore has at least one hydraulic container, connected to the cannula, for holding a hydraulic fluid and at least one pressure generation device. The pressure generation device is designed to apply pressure to the hydraulic fluid, wherein the sensor element can be transferred from the cannula into the body tissue using the hydraulic fluid.

Claims

1. An implantation device for implanting a sensor element for detecting at least one analyte in a bodily fluid or body tissue, comprising at least one cannula for piercing a skin surface of a patient, wherein the cannula has at least one holding area for holding the sensor element, wherein the implantation device has at least one hydraulic container, connected to the cannula, for holding a hydraulic fluid, wherein the implantation device has at least one pressure generation device, wherein the pressure generation device is designed to apply pressure to the hydraulic fluid, wherein the sensor element can be transferred from the cannula into the body tissue by a hydraulic pressure exerted by the hydraulic fluid, wherein the hydraulic fluid is supplied by a hydraulic reservoir into the hydraulic container via at least one connection and, wherein the connection comprises at least one valve, wherein the valve is designed to open in the case of negative pressure in the hydraulic container and permit subsequent flow of hydraulic fluid into the hydraulic container.

2. The implantation device according to claim 1, further comprising at least one device for setting and/or restricting the implantation depth, and wherein said at least one valve comprises a check valve.

3. The implantation device according to claim 2, wherein the device for setting and/or restricting the implantation depth comprises a resting surface for resting on the skin surface, wherein the resting surface at least partly annularly surrounds the cannula.

4. The implantation device according to claim 2, wherein the cannula and the hydraulic container form an implantation unit, with the device for setting and/or restricting the implantation depth being connected to the implantation unit via at least one spring element.

5. The implantation device according to claim 1, wherein the pressure generation device comprises at least one pressure piston held in the hydraulic container.

6. The implantation device according to claim 5, wherein the cannula and the hydraulic container form an implantation unit, with the implantation unit being movable axially along an axis of the implantation device, relative to the pressure piston.

7. The implantation device according to claim 5, wherein a position of the pressure piston can be fixed relative the skin surface, wherein the pressure piston is connected to at least one resting surface.

8. The implantation device according to claim 1, wherein the hydraulic fluid comprises a saline.

9. The implantation device according to claim 1, wherein the cannula is at least partly transparent to light in the ultraviolet spectral range.

10. The implantation device according to claim 9, further comprising at least one light source for crosslinking, and in the cannula, at least one material of the sensor element which can be crosslinked.

11. The implantation device according to claim 1, wherein the cannula has at least one constriction for limiting the holding area.

12. The implantation device according to claim 1, wherein the implantation device is designed to remove a sensor element implanted in the body tissue, wherein the pressure generation device is designed to generate negative pressure in the hydraulic fluid to allow the sensor element to be sucked into the cannula.

13. The implantation device according to claim 1, further comprising at least one sensor element for detecting at least one analyte in a bodily fluid or body tissue.

14. The implantation device according to claim 1, further comprising at least one device for setting and/or restricting the implantation depth, wherein the device for setting and/or restricting the implantation depth comprises a resting surface for resting on the skin surface, wherein the resting surface at least partly annularly surrounds the cannula, and wherein the cannula and the hydraulic container form an implantation unit, with the device for setting and/or restricting the implantation depth being connected to the implantation unit via at least one spring element.

15. The implantation device according to claim 14, wherein the valve is designed to open in the case of negative pressure in the hydraulic container and permit subsequent flow of hydraulic fluid into the hydraulic container.

16. The implantation device according to claim 15, wherein the cannula and the hydraulic container form an implantation unit, with the implantation unit being movable axially along an axis of the implantation device, relative to the pressure piston.

17. The implantation device according to claim 16, wherein a position of the pressure piston can be fixed relative the skin surface, wherein the pressure piston is connected to at least one resting surface.

18. The implantation device according to claim 17, wherein the cannula is at least partly transparent to light in the ultraviolet spectral range and further comprising at least one light source for crosslinking, and in the cannula, at least one material of the sensor element which can be crosslinked.

19. The implantation device according to claim 18, wherein the cannula has at least one constriction for limiting the holding area and further comprising at least one sensor element for detecting at least one analyte in a bodily fluid or body tissue.

20. The implantation device according to claim 2, wherein the at least one device for setting and/or restricting the implantation depth is a depth stop.

21. The implantation device according to claim 7, wherein the at least one resting surface is the resting surface of the device for setting and/or restricting the implantation depth.

22. The implantation device according to claim 8, wherein the saline is a physiological saline.

23. The implantation device according to claim 14, wherein the at least one device for setting and/or restricting the implantation depth is a depth stop.

24. The implantation device according to claim 17, wherein the at least one resting surface is the resting surface of the device for setting and/or restricting the implantation depth.

25. An implantation device for implanting a sensor element for detecting at least one analyte in a bodily fluid or body tissue, comprising at least one cannula for piercing a skin surface of a patient, wherein the cannula has at least one holding area for holding the sensor element, wherein the implantation device has at least one hydraulic container, connected to the cannula, for holding a hydraulic fluid, wherein the implantation device has at least one pressure generation device, wherein the pressure generation device is designed to apply pressure to the hydraulic fluid, wherein the sensor element can be transferred from the cannula into the body tissue by a hydraulic pressure exerted by the hydraulic fluid, wherein the hydraulic fluid is supplied by a hydraulic reservoir into the hydraulic container via at least one connection and, wherein the connection comprises at least one valve, wherein the pressure generation device comprises at least one pressure piston held in the hydraulic container, wherein a position of the pressure piston can be fixed relative the skin surface, wherein the pressure piston is connected to at least one resting surface, the connection being effected by means of a piston rod.

26. An implantation device for implanting a sensor element for detecting at least one analyte in a bodily fluid or body tissue, comprising at least one cannula for piercing a skin surface of a patient, wherein the cannula has at least one holding area for holding the sensor element, wherein the implantation device has at least one hydraulic container, connected to the cannula, for holding a hydraulic fluid, wherein the implantation device has at least one pressure generation device, wherein the pressure generation device is designed to apply pressure to the hydraulic fluid, wherein the sensor element can be transferred from the cannula into the body tissue by a hydraulic pressure exerted by the hydraulic fluid, wherein the hydraulic fluid is supplied by a hydraulic reservoir into the hydraulic container via at least one connection and, wherein the connection comprises at least one valve, wherein the cannula is at least partly transparent to light in the ultraviolet spectral range.

27. An implantation device for implanting a sensor element for detecting at least one analyte in a bodily fluid or body tissue, comprising at least one cannula for piercing a skin surface of a patient, wherein the cannula has at least one holding area for holding the sensor element, wherein the implantation device has at least one hydraulic container, connected to the cannula, for holding a hydraulic fluid, wherein the implantation device has at least one pressure generation device, wherein the pressure generation device is designed to apply pressure to the hydraulic fluid, wherein the sensor element can be transferred from the cannula into the body tissue by a hydraulic pressure exerted by the hydraulic fluid, wherein the hydraulic fluid is supplied by a hydraulic reservoir into the hydraulic container via at least one connection and, wherein the connection comprises at least one valve, wherein the implantation device is designed to remove a sensor element implanted in the body tissue, wherein the pressure generation device is designed to generate negative pressure in the hydraulic fluid to allow the sensor element to be sucked into the cannula.

28. An implantation device for implanting a sensor element for detecting at least one analyte in a bodily fluid or body tissue, comprising at least one cannula for piercing a skin surface of a patient, wherein the cannula has at least one holding area for holding the sensor element, wherein the implantation device has at least one hydraulic container, connected to the cannula, for holding a hydraulic fluid, wherein the implantation device has at least one pressure generation device, wherein the pressure generation device is designed to apply pressure to the hydraulic fluid, wherein the sensor element can be transferred from the cannula into the body tissue by a hydraulic pressure exerted by the hydraulic fluid, wherein the hydraulic fluid is supplied by a hydraulic reservoir into the hydraulic container via at least one connection and, wherein the connection comprises at least one valve;

further comprising at least one device for setting and/or restricting the implantation depth, wherein the device for setting and/or restricting the implantation depth comprises a resting surface for resting on the skin surface, wherein the resting surface at least partly annularly surrounds the cannula, and wherein the cannula and the hydraulic container form an implantation unit, with the device for setting and/or restricting the implantation depth being connected to the implantation unit via at least one spring element;

wherein the valve is designed to open in the case of negative pressure in the hydraulic container and permit subsequent flow of hydraulic fluid into the hydraulic container.