Thermal stimulation probe and method

• US 8,652,189 B2
• Filed: 12/26/2011
• Issued: 02/18/2014
• Est. Priority Date: 05/22/2003
• Status: Expired due to Term

• Current Assignee: Medoc Ltd.
• Original Assignee: Medoc Ltd.
• Inventors: Gafni, Ehud, Granovsky, Yelena
• Primary Examiner(s): Dvorak, Linda C
• Assistant Examiner(s): SMITH, KAITLYN ELIZABETH
• Application Number:
  US13/337,187
• Publication Number:
  US 20120095535A1
• Time in Patent Office: 785 Days
• Field of Search: 606/20, 606/27, 607/96
• US Class Current: 607/96
• CPC Class Codes: A61B 5/377 using evoked responses
• CPC Class Codes: A61B 5/383 Somatosensory stimuli, e.g. electric stimulation
• CPC Class Codes: A61B 5/4821 Determining level or depth of anaesthesia A61B5/1106 takes precedence
• CPC Class Codes: A61F 2007/0001 Body part
• CPC Class Codes: A61F 2007/0071 using a resistor, e.g. near the spot to be heated
• CPC Class Codes: A61F 2007/0075 using a Peltier element, e.g. near the spot to be heated or cooled
• CPC Class Codes: A61F 2007/0076 remote from the spot to be heated or cooled
• CPC Class Codes: A61F 7/007 characterised by electric heating

Abstract

A physiological thermal stimulation probe, comprising:

• • (a) an electrically controlled heat control element with a relatively low thermal capacity and adapted for contact with tissue on one side thereof;
  • (b) a thermal sink/source with a relatively high effective thermal capacity and a relatively low thermal impedance, such that said thermal sink/source sink can rapidly change a temperature of said heat control element, at a rate above 10 degrees Celsius per second, from a temperature of below 100 degrees Celsius; and
  • (c) circuitry which activates said heat control element to achieve a desired temperature stimulation profile of said tissue.

Claims

1. A physiological thermal stimulation probe, comprising:

(a) an electrically operated temperature stimulation element adapted for contact with tissue on one side thereof;

(b) a thermal capacity mass functioning as at least one of a thermal sink and a thermal source, said thermal capacity mass being thermally coupled to a side of said temperature stimulation element opposite to said side adapted for contact with tissue; and

(c) circuitry which activates said temperature stimulation element using a feedback loop which takes into account thermal heat transfer to or from said thermal capacity mass, to achieve a desired temperature stimulation profile of said tissue;

wherein said thermal capacity mass has a thermal capacity of at least four times a thermal capacity of said part of said temperature stimulation element; and

wherein said coupling of said thermal capacity mass to said temperature stimulation element is sufficient so that heat flow between the temperature stimulation element and the thermal capacity mass can change a temperature of said side adapted for contact with tissue of said temperature stimulation element at a rate above 10 degrees Celsius per second.

2. A physiological thermal stimulation probe according to claim 1, wherein said temperature stimulation element functions as a cooling element and wherein said thermal capacity mass functions as a heat source.

3. A physiological thermal stimulation probe according to claim 1, wherein said temperature stimulation element functions as a heating element and wherein said thermal capacity mass functions as a heat sink.

4. A probe according to claim 3, wherein said heat sink comprises a cold thermal mass.

5. A probe according to claim 4, wherein said cold thermal mass comprises a thermally conducting plate.

6. A probe according to claim 3, wherein said heat sink comprises an active cooling element.

7. A probe according to claim 4, wherein said heat sink comprises an active cooling element thermally coupled to said cold thermal mass.

8. A probe according to claim 6, wherein said active cooling element comprises a Peltier element.

9. A probe according to claim 6, wherein said active cooling element comprises a heat pump.

10. A probe according to claim 7, comprising at least one temperature sensor in association with said cold thermal mass, wherein said circuitry applies closed loop feedback to control a temperature of said cold thermal mass using said temperature sensor to control an activation of said active cooling element.

11. A probe according to claim 3, comprising at least one temperature sensor in association with said temperature stimulation element, wherein said circuitry applies closed loop feedback to control a temperature of said temperature stimulation element using said temperature sensor to control an activation of said temperature stimulation element.

12. A probe according to claim 10, wherein said circuitry samples said at least one temperature sensor at faster than 10 Hz.

13. A probe according to claim 10, wherein said circuitry samples said at least one temperature sensor at faster than 50 Hz.

14. A probe according to claim 3, wherein said circuitry controls said probe to provide a pulse of heat.

15. A probe according to claim 3, wherein said circuitry controls said probe to provide a pulse of cold.

16. A probe according to claim 3, wherein said circuitry controls said probe to selectively stimulate A-delta fibers.

17. A probe according to claim 3, wherein said circuitry controls said probe to selectively stimulate a subgroup of A-delta fibers.

18. A probe according to claim 17, wherein said sub-group comprises cold sensing fibers.

19. A probe according to claim 17, wherein said sub-group comprises either high or low threshold fibers.

20. A probe according to claim 3, wherein said circuitry controls said probe to selectively stimulate C fibers.

21. A probe according to claim 3, wherein said circuitry controls said probe to generate a windup effect.

22. A probe according to claim 3, wherein said circuitry controls said probe to provide a second pain effect.

23. A probe according to claim 3, wherein said circuitry controls said probe to have a temperate raise rate of over 30 degrees Celsius per second.

24. A probe according to claim 3, wherein said circuitry controls said probe to have a temperate decrease rate of over 30 degrees Celsius per second.

25. A probe according to claim 3, wherein said heating element comprises an array of individually controllable heating elements.

26. A probe according to claim 3, wherein said heating element comprises a foil heater.

27. A probe according to claim 3, wherein said circuitry includes a trigger input for triggering stimulation.

28. A probe according to claim 3, wherein said circuitry includes a trigger output for generating an external trigger.

29. A probe according to claim 3, wherein said circuitry maintains said probe at a neutral temperature by providing an activation of said heating element to offset the effect of said heat sink.

30. A probe according to claim 3, wherein said circuitry pre-cools said heat sink.

31. A probe according to claim 1, including means for sensing brain activity.

32. A probe according to claim 31, including circuitry adapted to extract a degree of pain blocking from said sensed brain activity.

33. A probe according to claim 31, including circuitry adapted to extract a consciousness level from said sensed brain activity.

34. A probe according to claim 1, wherein said circuitry is configured to control said temperature stimulation elements to produce sharp temperature spikes including a sharp leading edge, a short duration and a sharp trailing edge such that a spike of at least 10 C is shorter than 2 seconds.

35. A probe according to claim 1, wherein said profile comprises at least one spike with substantially linear-rate temperature changes.

36. The probe according to claim 1, wherein electrification of said temperature stimulation element is changed to affect a drop or increase in temperature of said temperature stimulation element.