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Method and apparatus for the detection of pathogens, parasites, toxins and desired chemical compounds

  • US 8,652,311 B1
  • Filed: 04/01/2011
  • Issued: 02/18/2014
  • Est. Priority Date: 10/02/2006
  • Status: Active Grant
First Claim
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1. A flow-through immuno-sensor with electrochemical detection capabilities, comprising:

  • a body;

    an electrode assembly housed within the body, the electrode assembly comprisinga first substrate supporting a working electrodea second substrate supporting a reference electrode and a counter electrode;

    a detector configured to detect an electrical signal generated by the working electrode;

    wherein the body also has a fluid inlet configured to introduce a fluid sample into the body;

    a fluid path in communication with the fluid inlet, the fluid path being configured to allow fluid to encounter the working electrode, the counter electrode, and the reference electrode; and

    an outlet channel;

    wherein the working electrode comprises immobilized antibody or antigen and is configured for an enzyme reaction so forming a reaction region; and

    wherein when test sample comprising a target analyte antibody or antigen is introduced to the reaction region via the inlet channel under sufficient conditions for the target analyte to bind to the immobilized antibody or antigen, unbound molecules in test sample exit the reaction region via the outlet channel, and thereafter when one or more detection molecules are introduced to the reaction region an enzymatic reaction will occur, the product of which is able to produce a detectable alteration in the working electrode'"'"'s signal output.

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