Devices and methods for tissue engineering
First Claim
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1. A method of fabricating a synthetic bone prosthesis comprising:
- mixing a bioactive glass fiber with a pore former and a liquid to provide a plastically formable batch;
kneading the formable batch to distribute the bioactive glass fiber with the pore former, to provide a formable batch of a homogeneous mass of intertangled and overlapping bioactive glass fiber;
forming the formable batch into a desired shape to provide a shaped form;
drying the shaped form to remove the liquid; and
heating the shaped form to a bond formation temperature using an exothermic reaction of the pore former to form bonds between the intertangled and overlapping bioactive glass fiber.
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Abstract
A resorbable tissue scaffold fabricated from bioactive glass fiber forms a rigid three-dimensional porous matrix having a bioactive composition. Porosity in the form of interconnected pore space is provided by the space between the bioactive glass fiber in the porous matrix. Strength of the bioresorbable matrix is provided by bioactive glass that fuses and bonds the bioactive glass fiber into the rigid three-dimensional matrix. The resorbable tissue scaffold supports tissue in-growth to provide osteoconductivity as a resorbable tissue scaffold, used for the repair of damaged and/or diseased bone tissue.
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9 Claims
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1. A method of fabricating a synthetic bone prosthesis comprising:
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mixing a bioactive glass fiber with a pore former and a liquid to provide a plastically formable batch; kneading the formable batch to distribute the bioactive glass fiber with the pore former, to provide a formable batch of a homogeneous mass of intertangled and overlapping bioactive glass fiber; forming the formable batch into a desired shape to provide a shaped form; drying the shaped form to remove the liquid; and heating the shaped form to a bond formation temperature using an exothermic reaction of the pore former to form bonds between the intertangled and overlapping bioactive glass fiber. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9)
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Specification