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Bio-degradable block co-polymers for controlled release

  • US 8,652,506 B2
  • Filed: 06/05/2008
  • Issued: 02/18/2014
  • Est. Priority Date: 06/05/2008
  • Status: Active Grant
First Claim
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1. An implantable medical device having a coating thereon wherein the coating comprises a block or graft copolymer that comprises at least a first block, a second block different from the first block, and a third block, wherein the first block is a poly(lactide-glycolide) copolymer,the second block is a member of the group consisting of lactide-glycolide copolymer having a higher percentage of lactide than the first block copolymer, polylactide homopolymer, poly(trimethylene carbonate), poly(caprolactone), poly(β

  • -butyrolactone), poly(δ

    -valerolactone), and poly(tyrosine carbonate),the first and second blocks are characterized by respective degradation rates when the block copolymer is placed in the body of a subject animal, the degradation rate of the first block being greater than the degradation rate of the second block, andthe third block being characterized by a degradation rate when the block copolymer is placed in the body of a subject animal that is different from the respective degradation rates of the first and second blocks.

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