Bio-degradable block co-polymers for controlled release
First Claim
1. An implantable medical device having a coating thereon wherein the coating comprises a block or graft copolymer that comprises at least a first block, a second block different from the first block, and a third block, wherein the first block is a poly(lactide-glycolide) copolymer,the second block is a member of the group consisting of lactide-glycolide copolymer having a higher percentage of lactide than the first block copolymer, polylactide homopolymer, poly(trimethylene carbonate), poly(caprolactone), poly(β
- -butyrolactone), poly(δ
-valerolactone), and poly(tyrosine carbonate),the first and second blocks are characterized by respective degradation rates when the block copolymer is placed in the body of a subject animal, the degradation rate of the first block being greater than the degradation rate of the second block, andthe third block being characterized by a degradation rate when the block copolymer is placed in the body of a subject animal that is different from the respective degradation rates of the first and second blocks.
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Accused Products
Abstract
A block or graft copolymer includes a first block, and a second block different from the first block, wherein the first block is a poly(lactide-glycolide) copolymer. The polymers may be formulated in compositions with drug components for use in coating medical devices such as stents. Different blocks of the block or graft copolymer degrade in the body at different rates. The drug release profile from the coating is a combination the individual release rates of the different blocks and so can be controlled by controlling the selection and relative amounts of the respective blocks.
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Citations
11 Claims
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1. An implantable medical device having a coating thereon wherein the coating comprises a block or graft copolymer that comprises at least a first block, a second block different from the first block, and a third block, wherein the first block is a poly(lactide-glycolide) copolymer,
the second block is a member of the group consisting of lactide-glycolide copolymer having a higher percentage of lactide than the first block copolymer, polylactide homopolymer, poly(trimethylene carbonate), poly(caprolactone), poly(β - -butyrolactone), poly(δ
-valerolactone), and poly(tyrosine carbonate),the first and second blocks are characterized by respective degradation rates when the block copolymer is placed in the body of a subject animal, the degradation rate of the first block being greater than the degradation rate of the second block, and the third block being characterized by a degradation rate when the block copolymer is placed in the body of a subject animal that is different from the respective degradation rates of the first and second blocks. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11)
- -butyrolactone), poly(δ
Specification