Modulation of angiopoietin-like 3 expression
First Claim
1. A method of reducing angiopoietin-like protein 3 (ANGPTL3) ANGPTL3 expression in an animal comprising administering to the animal a compound comprising a modified oligonucleotide 10 to 30 linked nucleosides in length targeted to ANGPTL3, wherein expression of ANGPTL3 is reduced by at least 40% in the animal.
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Abstract
Provided herein are methods, compounds, and compositions for reducing expression of an ANGPTL3 mRNA and protein in an animal. Also provided herein are methods, compounds, and compositions for reducing plasma lipids, plasma glucose and atherosclerotic plaques in an animal. Such methods, compounds, and compositions are useful to treat, prevent, delay, or ameliorate any one or more of cardiovascular disease or metabolic disease, or a symptom thereof.
24 Citations
17 Claims
- 1. A method of reducing angiopoietin-like protein 3 (ANGPTL3) ANGPTL3 expression in an animal comprising administering to the animal a compound comprising a modified oligonucleotide 10 to 30 linked nucleosides in length targeted to ANGPTL3, wherein expression of ANGPTL3 is reduced by at least 40% in the animal.
Specification