Device for measuring concentration of constituent in blood and measuring method

• US 8,655,426 B2
• Filed: 04/23/2009
• Issued: 02/18/2014
• Est. Priority Date: 04/25/2008
• Status: Expired due to Fees

• Current Assignee: DENSO Corporation, Nippon Soken, Inc. (DENSO Corporation)
• Original Assignee: DENSO Corporation, Nippon Soken, Inc. (DENSO Corporation)
• Inventors: Osaki, Rie, Komura, Takashi, Nishii, Katsuyoshi, Tatsumoto, Hirohiko, Haseo, Yasuyuki
• Primary Examiner(s): Hindenburg, Max
• Assistant Examiner(s): Pani, John
• Application Number:
  US12/385,901
• Publication Number:
  US 20090270701A1
• Time in Patent Office: 1,762 Days
• Field of Search: 600310-344, 600/473, 600475-478
• US Class Current: 600/322
• CPC Class Codes: A61B 2562/146 for optical coupling
• CPC Class Codes: A61B 5/14532 for measuring glucose, e.g. by tissue impedance measurement
• CPC Class Codes: A61B 5/14546 for measuring analytes not otherwise provided for, e.g. ions, cytochromes

Abstract

A device for measuring concentration of a constituent in blood includes: an irradiation unit for irradiating light toward a living body, the light having a wavelength disposed in a light absorption band of the constituent in the blood; a light receiving unit for receiving light, which is reflected in the living body or transmitted through the living body; and a concentration measurement unit for measuring the concentration of the constituent in the blood based on variation of light intensity of light received by the light receiving unit, the variation attributed to a pulse wave of the living body.

Claims

1. A device for measuring concentration of a constituent in blood comprising:

a main body unit having dimensions capable of accommodating an inserted living body;

an irradiation unit disposed on an inner surface of the main body unit, for irradiating light toward the living body when inserted, the light having a wavelength disposed in a light absorption band of the constituent in the blood;

a light receiving unit for receiving light, which is reflected in the living body when inserted, or transmitted through the living body when inserted; and

a concentration measurement unit for measuring the concentration of the constituent in the blood based on variation of light intensity of light received by the light receiving unit, the variation attributed to a pulse wave of the living body when inserted,

wherein the main body unit has a V-shaped bottom,

wherein the irradiation unit and the light receiving unit are disposed on the V-shaped bottom, and

wherein the irradiation unit has an optical axis, which intersects with an optical axis of the light receiving unit,

wherein the irradiation unit has a rounded irradiation surface,

wherein the light receiving unit has a rounded reception surface, and

wherein the rounded irradiation surface and the rounded reception surface are each capable of contacting the living body.

2. The device according to claim 1,

wherein the concentration measurement unit measures the concentration of the constituent in the blood based on variation of a wave height of light intensity attributed to the pulse wave of the living body when inserted.

3. The device according to claim 2,

wherein the concentration measurement unit measures the concentration of the constituent in the blood based on a comparison between the wave height of light intensity and a predetermined reference wave height.

4. The device according to claim 3, further comprising:

a memory for storing a standard curve between a wave height ratio and the concentration of the constituent in blood,

wherein the concentration measurement unit calculates the wave height ratio between the wave height of light intensity and the predetermined reference wave height, and

wherein the concentration measurement unit measures the concentration of the constituent in the blood based on the wave height ratio and the standard curve.

5. The device according to claim 2,

wherein the irradiation unit is capable of irradiating a plurality of types of light having different wavelengths,

wherein the light receiving unit is capable of receiving the plurality of types of light,

wherein the concentration measurement unit calculates the wave height of light intensity in each type of light, and

wherein the concentration measurement unit measures the concentration of the constituent in the blood based on a comparison between the wave heights in different types of light.

6. The device according to claim 5,

wherein the plurality of types of light includes a first light having a first wavelength and a second light having a second wavelength,

wherein the concentration measurement unit calculates a first wave height of light intensity in the first light, and calculates a second wave height of light intensity in the second light,

wherein the concentration measurement unit calculates a ratio between the first and second wave heights, and

wherein the concentration measurement unit measures the concentration of the constituent in the blood based on a comparison between the ratio and a predetermined reference ratio.

7. The device according to claim 6, further comprising:

a memory for storing a standard curve between the ratio and the concentration of the constituent in blood,

wherein the concentration measurement unit measures the concentration of the constituent in the blood based on the ratio and the standard curve.

8. The device according to claim 1,

wherein the main body unit has dimensions capable of accommodating a fingertip of the inserted living body, and

wherein the irradiation unit is configured to irradiate light toward the fingertip of the living body when inserted.

9. The device according to claim 1, wherein:

the irradiation unit is further configured to press-contact the living body when inserted, and

the device further comprises a holding unit for maintaining a pressure at which the irradiation unit press-contacts the inserted living body when inserted.

10. The device according to claim 1,

wherein the constituent in blood is alcohol, glucose, glycogen, protein or cholesterol.

11. The device according to claim 1,

wherein, the wavelength of the light is in a range between 800 nm and 1400 nm.