Blood flow bypass catheters and methods for the delivery of medium to the vasculature and body ducts
First Claim
1. A catheter device for insertion into a vascular structure or body duct, said catheter device having a distal end and a proximal end for delivery of a medium to a lesion, said device comprising:
- a blood lumen for allowing blood to pass there through;
a medium lumen for the delivery of a medium to the lesion, said medium lumen comprising at least one medium egress port for communication with the lesion;
an expandable component disposed on said catheter device to block or impede the vascular flow of blood in the vascular structure or body duct; and
said blood lumen comprising at least one blood entrance port proximally before said expandable component to allow blood to enter and at least one blood egress port distally beyond said expandable component to allow blood to pass distally beyond said expandable component,wherein, a position of said inlet ports and said exit ports is determined by application of a global optimization algorithm comprising;
selecting variables including;
a) geometrical shapes and dimensions of at least one of said blood lumen and said medium lumen,b) relative locations and orientations of flow planes of at least one of said blood entrance port and blood egress port, andc) concentration and residence time of the medium in the vicinity of a specific location outside said catheter device; and
applying the global optimization algorithm to the variables to generate a catheter with optimized flow conditions.
0 Assignments
0 Petitions
Accused Products
Abstract
A catheterization device that may be designed by use of an adaptive genetic algorithm computational fluid dynamics approach, as well as other Global Optimization methods that may include simulated annealing, multistart and interval methods, continuous branch and bound methods, evolutionary algorithms, and tabu search and scatter search methods, as well as other available Global Optimization methods that is able to maximize/optimize the dwell time of an infused agent in the vicinity of a vascular lesion. The device may have an internal by-pass channel that allows the blood upstream of the lesion to continue its pulsatile flow through the vessel in the part of it occluded by the lesion, while simultaneously allowing the disbursement and maximal dwell time of an antithrombolytic or other diagnostic or therapeutic agent needed to treat the lesion.
66 Citations
19 Claims
-
1. A catheter device for insertion into a vascular structure or body duct, said catheter device having a distal end and a proximal end for delivery of a medium to a lesion, said device comprising:
-
a blood lumen for allowing blood to pass there through; a medium lumen for the delivery of a medium to the lesion, said medium lumen comprising at least one medium egress port for communication with the lesion; an expandable component disposed on said catheter device to block or impede the vascular flow of blood in the vascular structure or body duct; and said blood lumen comprising at least one blood entrance port proximally before said expandable component to allow blood to enter and at least one blood egress port distally beyond said expandable component to allow blood to pass distally beyond said expandable component, wherein, a position of said inlet ports and said exit ports is determined by application of a global optimization algorithm comprising; selecting variables including; a) geometrical shapes and dimensions of at least one of said blood lumen and said medium lumen, b) relative locations and orientations of flow planes of at least one of said blood entrance port and blood egress port, and c) concentration and residence time of the medium in the vicinity of a specific location outside said catheter device; and applying the global optimization algorithm to the variables to generate a catheter with optimized flow conditions. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9)
-
-
10. A method for delivering a medium to a lesion inside of a vascular structure or body duct by inserting a catheter device into a subject, said catheter device having a distal end and a proximal end, lumens there through, medium port holes, a blood inlet port, and a blood exit port, wherein said method comprises:
-
inflating an expandable component to block or impede the vascular flow of blood or other body fluid through the vasculature structure or the body duct; delivering the medium through one of said lumens to said lesion through at least one of said medium port holes; and allowing blood of the vasculature of the subject to proximally enter through said blood inlet port and flow through one of said lumens and to exit on a side of said lesion toward said distal end of said catheter device through said blood exit port, wherein, a position of said inlet ports and said exit ports is determined by application of a global optimization algorithm comprising; selecting variables including; a) geometrical shapes and dimensions of at least one of said lumens, b) relative locations and orientations of flow planes of at least one of said blood inlet port and said blood exit port, and c) concentration and residence time of the medium in the vicinity of a specific location outside said catheter device; and applying the global optimization algorithm to the variables to generate a catheter with optimized flow conditions. - View Dependent Claims (11, 12, 13, 14, 15, 16, 17, 18, 19)
-
Specification