System and method of measuring changes in arterial volume of a limb segment

• US 8,657,755 B2
• Filed: 10/04/2011
• Issued: 02/25/2014
• Est. Priority Date: 05/12/2009
• Status: Active Grant

• Current Assignee: Angiologix, Inc. (Everist Genomics, Inc.)
• Original Assignee: Angiologix, Inc. (Everist Genomics, Inc.)
• Inventors: Parfenov, Alexander S., Parfenova, Maria A., Konstantinov, Nikolay V.
• Primary Examiner(s): Mallari, Patricia
• Assistant Examiner(s): JANG, CHRISTIAN YONGKYUN
• Application Number:
  US13/252,245
• Publication Number:
  US 20120259236A1
• Time in Patent Office: 875 Days
• Field of Search: 600/507, 600500-504
• US Class Current: 600/507
• CPC Class Codes: A61B 5/02116 of pulse wave amplitude A61B5/02225 takes precedence
• CPC Class Codes: A61B 5/02125 of pulse wave propagation time
• CPC Class Codes: A61B 5/02141 Details of apparatus construction, e.g. pump units or housings therefor, cuff pressurising systems, arrangements of fluid conduits or circuits A61B5/02233, A61B5/0235 take precedence
• CPC Class Codes: A61B 5/022 by applying pressure to close blood vessels, e.g. against the skin; Ophthalmodynamometers
• CPC Class Codes: A61B 5/02225 using the oscillometric method
• CPC Class Codes: A61B 5/026 Measuring blood flow A61B3/1233, A61B3/1241 take precedence
• CPC Class Codes: A61B 5/14542 for measuring blood gases A61B5/14551 takes precedence
• CPC Class Codes: A61B 5/4884 inducing physiological or psychological stress, e.g. applications for stress testing
• CPC Class Codes: A61B 5/6824 Arm or wrist
• CPC Class Codes: A61B 5/7239 using differentiation including higher order derivatives

Abstract

A medical diagnostic device performs diagnostics for assessing the ability of the arteries to respond to an increase in blood flow. The medical diagnostic device determines relative changes in arterial volume of the limb segment during a time period after a stimulus relative to the arterial volume of the limb segment during a baseline period using the amplitudes or other portions of the component pulse waves (such as early systolic components) of volume pulse waves during the baseline period and after the stimulus.

Claims

1. A diagnostic system for assessing a change in arterial volume of a limb segment of a mammal, the diagnostic system comprising:

a sensor configured to detect a baseline volume pulse wave of a limb segment during a baseline period and an after-stimulus volume pulse wave of the limb segment during an after-stimulus period, the sensor being configured to operatively engage the limb segment at a position proximal from individual digits of the limb;

wherein the sensor includes a pressure sensor configured to sense a pressure of an inflatable cuff associated with the limb segment; and

wherein, when inflated above about systolic pressure, the inflatable cuff substantially occludes an artery of the limb segment; and

a processor operatively coupled to the sensor, the processor being configured to determine an amplitude of an early systolic component of the baseline volume pulse wave, an amplitude of an early systolic component of the after-stimulus volume pulse wave, and a change in arterial volume of the limb segment from the baseline period to the after-stimulus period using the amplitude of the early systolic component of the baseline volume pulse wave and the amplitude of the early systolic component of the after-stimulus volume pulse wave; and

wherein the processor is configured to control the cuff to apply, in series, an external pressure to the limb segment at about a mean arterial pressure of the limb, the external pressure being applied during the baseline period and the after-stimulus period.

2. The diagnostic system of claim 1, wherein the processor is configured to control the cuff to apply an external pressure to the limb segment at a pressure level which allows blood flow through the artery to produce the baseline volume pulse wave and at the after-stimulus volume pulse wave.

3. The diagnostic system of claim 1,

wherein the processor is configured to control the cuff to apply an external pressure to the limb segment as a gradually varying pressure between near-systolic and near-diastolic, and

wherein the processor is configured to control the sensor to detect the baseline volume pulse wave and at the after-stimulus volume pulse wave while the external pressure is between systolic and diastolic.

4. The diagnostic system of claim 3, wherein the processor is configured to control the cuff to apply the external pressure to the limb segment at a pressure near systolic, and gradually reducing the pressure to near diastolic.

5. The diagnostic system of claim 3, wherein the processor is configured to control the cuff to apply the external pressure to the limb segment at a pressure near diastolic, and gradually increasing to the pressure to near systolic.

6. The diagnostic system of claim 1,

wherein the processor is configured to control the cuff to cycle an external pressure applied to the limb segment between a high level and a low level,

wherein the processor is configured to determine the amplitude of the early systolic component of the baseline volume pulse wave and the amplitude of the early systolic component of the after-stimulus volume pulse wave while the external pressure is at the high level.

7. The diagnostic system of claim 6, wherein the high level is near mean arterial pressure and the low level is below venous pressure.

8. The diagnostic system of claim 6, wherein the high level is below diastolic pressure and the low level is below venous pressure.