Intravascular diagnostic or therapeutic apparatus using high-intensity pulsed light

• US 8,657,811 B2
• Filed: 05/06/2004
• Issued: 02/25/2014
• Est. Priority Date: 05/01/2003
• Status: Active Grant

• Current Assignee: KEIO University
• Original Assignee: KEIO University
• Inventors: Arai, Tsunenori, Suga, Eriko, Yamashita, Erika, Futami, Hikaru
• Primary Examiner(s): Thomson, Bill
• Assistant Examiner(s): LIPITZ, JEFFREY BRIAN
• Application Number:
  US10/554,871
• Publication Number:
  US 20080221560A1
• Time in Patent Office: 3,582 Days
• Field of Search: 606 2- 19, 600/476, 128/898, 607 88- 92
• US Class Current: 606/14
• CPC Class Codes: A61B 1/015 Control of fluid supply or evacuation
• CPC Class Codes: A61B 1/042 characterised by a proximal camera, e.g. a CCD camera
• CPC Class Codes: A61B 1/3137 for examination of the interior of blood vessels
• CPC Class Codes: A61B 18/24 with a catheter A61B18/26, A61B18/28 take precedence
• CPC Class Codes: A61B 5/0084 for introduction into the body, e.g. by catheters A61B5/1459 takes precedence
• CPC Class Codes: A61B 5/02007 Evaluating blood vessel condition, e.g. elasticity, compliance
• CPC Class Codes: A61B 5/7285 for synchronising or triggering a physiological measurement or image acquisition with a physiological event or waveform, e.g. an ECG signal A61B6/5205, A61B6/541, A61B8/5207, A61B8/543 take precedence

Abstract

An intravascular diagnostic or therapeutic apparatus capable of removing blood in an intravascular lumen to be observed using a minimally invasive method is provided. The apparatus includes high-intensity pulsed light generating means and high-intensity pulsed light transmitting means for transmitting high-intensity pulsed light, capable of irradiating the interior of a blood vessel with high-intensity pulsed light, producing water-vapor bubbles and temporarily removing the blood in the blood vessel.

Claims

1. An intravascular apparatus for obtaining visible images of an interior of a blood vessel, comprising:

(A) a catheter configured to be inserted into the blood vessel, the catheter comprising;

(i) a first light transmitting fiber that includes a first light irradiation section and that is connected to a first light source, which generates a pulsed first light and which transmits the pulsed first light via the first light transmitting fiber to the first light irradiation section, wherein the pulsed first light irradiates into the blood vessel to generate bubbles within the blood vessel;

(ii) a second light transmitting fiber that includes a second irradiation section and that is connected to a second light source, which generates a visible second light and which transmits the visible second light via the second light transmitting fiber to the second light irradiation section, wherein the visible second light irradiates into the blood vessel to illuminate the interior of the blood vessel to enable optical observation during generation of the bubbles; and

(iii) an image guide that includes an observation section and is connected to an imaging device configured to obtain images of the interior of the blood vessel; and

(B) a delay generator, connected to the first light source and the second light source, that is configured to receive a signal from an electrocardiograph or a pressure sensor, wherein said signal correlates with pulsating blood flow within the blood vessel, such that, when the pulsating blood flow decreases, the delay generator (a) triggers the first light source to irradiate the pulsed first light and (b) triggers the second light source to irradiate the visible second light several tens of μ

s to several hundreds of μ

s after the first light source is triggered.

2. The intravascular apparatus for obtaining visible images of the interior of the blood vessel according to claim 1, wherein the catheter further includes a liquid feeding channel, wherein the liquid feeding channel includes an injection port and is connected to a liquid reservoir, and wherein the liquid feeding channel replaces blood in a local region irradiated with the pulsed first light with a liquid whose absorbability of the pulsed first light is close to that of water.

3. The intravascular apparatus for obtaining visible images of the interior of the blood vessel according to claim 1, wherein the visible second light comprises an ultraviolet light having a wavelength less than or equal to 400 nm so that the blood vessel relaxes.

4. The intravascular apparatus for obtaining visible images of the interior of the blood vessel according to claim 1, wherein the visible second light comprises a visible light having a wavelength around 458 nm or 514.5 nm or infrared light having a wavelength greater than or equal to 800 nm so that the blood vessel contracts.

5. The intravascular apparatus for obtaining visible images of the interior of the blood vessel according to claim 1, wherein the visible second light comprises high intensity light.

6. The intravascular apparatus for obtaining visible images of the interior of the blood vessel according to claim 1, wherein the visible second light comprises a free electron laser having a wavelength of about 5.75 μ

m so that atheroma of arterial sclerosis in the blood vessel or thrombus in the blood vessel is destroyed.

7. The intravascular apparatus for obtaining visible images of the interior of the blood vessel according to claim 1, wherein the second light source is selected from a group consisting of light generated by a solid laser, semiconductor laser, dye laser, variable wavelength near-infrared laser, optical parametric oscillator (OPO), Raman laser, and a non-linear optical converter and flash lamp.

8. The intravascular apparatus for obtaining visible images of the interior of the blood vessel according to claim 1, wherein the pulsed first light is generated by an optical parametric oscillator (OPO).

9. The intravascular apparatus for obtaining visible images of the interior of the blood vessel according to claim 1, wherein the first light source comprises a laser, wherein the laser is a solid laser using rare-earth ions.

10. The intravascular apparatus for obtaining visible images of the interior of the blood vessel according to claim 9, wherein a laser medium is Ho or Tm and a laser base material is selected from a group of YAG, YLF, YSGG and YVO.

11. The intravascular apparatus for obtaining visible images of the interior of the blood vessel according to claim 10, wherein the laser is Ho:

YAG laser or Tm;

YAG laser.

12. The intravascular apparatus for obtaining visible images of the interior of the blood vessel according to claim 1, which further comprises a diagnostic or therapeutic apparatus configured to mechanically process the interior of the blood vessel.

13. The intravascular apparatus for obtaining visible images of the interior of the blood vessel according to claim 12, wherein the diagnostic or therapeutic apparatus is selected from a group consisting of a directional atherectomy apparatus, thrombus aspirator, rotablator and apparatus for biopsy.

14. The intravascular apparatus for obtaining visible images of the interior of the blood vessel according to claim 1, wherein the wavelength of the pulsed first light ranges from 1.5 μ

m to 3 μ

m.

15. The intravascular apparatus for obtaining visible images of the interior of the blood vessel according to claim 1, wherein the wavelength of the pulsed first light ranges from 1.5 μ

m to 2.5 μ

m.

16. The intravascular apparatus for obtaining visible images of the interior of the blood vessel according to claim 1, wherein the wavelength of the pulsed first light is 1.9 μ

m.

17. The intravascular apparatus for obtaining visible images of the interior of the blood vessel according to claim 1, wherein the pulse width of the pulsed first light ranges from 100 μ

s to 1 ms.

18. The intravascular apparatus for obtaining visible images of the interior of the blood vessel according to claim 1, wherein the pulse width of the pulsed first light ranges from 150 μ

s to 250 μ

s.

19. The intravascular apparatus for obtaining visible images of the interior of the blood vessel according to claim 1, wherein the first light irradiation section protrudes from the catheter.

20. The intravascular apparatus for obtaining visible images of the interior of the blood vessel according to claim 1, wherein the catheter further includes a pressure sensor connected to the first light source.

21. The intravascular apparatus for obtaining visible images of the interior of the blood vessel according to claim 1, further comprising an electrocardiogram connected to the delay generator and the first light source.

22. The intravascular apparatus for obtaining visible images of the interior of the blood vessel according to claim 1, wherein the pulsed first light has a wavelength that ranges from 0.3 μ

m to 3 μ

m and a pulse width that ranges from 10 ns to 10 ms.

23. A method for obtaining visible images of an interior of a blood vessel, comprising:

(A) inserting a catheter into the blood vessel of a subject, the catheter comprising;

(i) a first light transmitting fiber that includes a first light irradiation section and that is connected to a first light source, which generates a pulsed first light and which transmits the pulsed first light via a first light transmitting fiber to the first light irradiation section, wherein the pulsed first light irradiates into the blood vessel to generate bubbles within the blood vessel;

(ii) a second light transmitting fiber that includes a second irradiation section and that is connected to a second light source, which generates a visible second light and which transmits the visible second light via the second light transmitting fiber to the second light irradiation section, wherein the visible second light irradiates into the blood vessel to illuminate the interior of the blood vessel to enable optical observation during generation of the bubbles; and

(iii) an image guide that includes an observation section and is connected to an imaging device configured to obtain images of the interior of the blood vessel, wherein the first light source and the second light source are connected to a delay generator; and

then

(B) irradiating the pulsed first light into the blood vessel to generate bubbles when pulsating blood flow within the blood vessel decreases;

(C) irradiating the visible second light with delay between the irradiation of the visible second light and the pulsed first light such that the visible second light is irradiated several tens of μ

s to several hundreds of μ

s after step (B) occurs; and

(D) obtaining the images of the interior of the blood vessel.

24. The method according to claim 23, wherein the first light source is connected to a pressure sensor, and wherein step (B) occurs when a pulsating blood flow monitored by the pressure sensor decreases.

25. The method according to claim 23, wherein the delay generator is connected to an electrocardiogram, and wherein step (B) occurs when a pulsating blood flow monitored by the electrocardiogram decreases.

26. The method according to claim 23, further comprising feeding liquid, whose absorbability of the pulsed first light is close to that of water, into the blood vessel before step (C) to replace blood in a local region irradiated with the pulsed light with the liquid, wherein the catheter further includes a liquid feeding channel which includes an injection port and is connected to a liquid reservoir.

27. The method according to claim 23, wherein the visible second light comprises an ultraviolet light having a wavelength less than or equal to 400 nm and the irradiation of the visible second light relaxes the blood vessel.

28. The method according to claim 23, wherein the visible second light comprises a visible light having a wavelength around 458 nm or 514.5 nm or infrared light having a wavelength greater than or equal to 800 nm and the irradiation of the visible second light contracts the blood vessel.

29. The method according to claim 23, wherein the visible second light comprises high intensity light.

30. The method according to claim 23, wherein the visible second light comprises a free electron laser having a wavelength of about 5.75 μ

m and destroying atheroma of arterial sclerosis in the blood vessel or thrombus in the blood vessel.

31. The method according to claim 23, wherein the second light source is selected from a group consisting of light generated by a solid laser, semiconductor laser, dye laser, variable wavelength near-infrared laser, optical parametric oscillator (OPO), Raman laser, and a non-linear optical converted and flash lamp.

32. The method according to claim 23, wherein the pulsed first light is generated by an optical parametric oscillator (OPO).

33. The method according to claim 23, wherein the first light source comprises a laser, wherein the laser is a solid laser using rare-earth ions.

34. The method according to claim 23, wherein a laser medium is Ho or Tm and a laser base material is selected from a group of YAG, YLF, YSGG and YVO.

35. The method according to claim 23, wherein the laser is a Ho:

YAG laser or a Tm;

YAG laser.

36. The method according to claim 23, further comprising conducting diagnostic or therapy.

37. The method according to claim 36, wherein the therapy is conducted by an apparatus selected from the group consisting of directional atherectomy apparatus, thrombus aspirator, rotablator and apparatus for biopsy.

38. The method according to claim 23, wherein the pulsed first light has a wavelength that ranges from 0.3 μ

m to 3 μ

m and a pulse width that ranges from 10 ns to 10 ms.