Preparation of a lipid blend and a phospholipid suspension containing the lipid blend

• US 8,658,205 B2
• Filed: 08/01/2011
• Issued: 02/25/2014
• Est. Priority Date: 01/14/1998
• Status: Expired due to Fees

• Current Assignee: Lantheus Medical Imaging, Inc. (Lantheus Holdings, Inc.)
• Original Assignee: Lantheus Medical Imaging, Inc. (Lantheus Holdings, Inc.)
• Inventors: Hui, Poh K., Bishop, John E., Madrigal, Eleodoro S. Jr.
• Primary Examiner(s): KISHORE, GOLLAMUDI S
• Application Number:
  US13/195,734
• Publication Number:
  US 20120027688A1
• Time in Patent Office: 939 Days
• Field of Search: 424/450, 424/9.51, 264/4.1, 264/4.3
• US Class Current: 424/450
• CPC Class Codes: A61B 8/00 Diagnosis using ultrasonic, sonic or infrasonic waves imaging of objects using sonar G01S15/00
• CPC Class Codes: A61K 47/10 Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
• CPC Class Codes: A61K 47/24 containing atoms other than carbon, hydrogen, oxygen, halogen, nitrogen or sulfur, e.g. cyclomethicone or phospholipids
• CPC Class Codes: A61K 49/226 Solutes, emulsions, suspensions, dispersions, semi-solid forms, e.g. hydrogels
• CPC Class Codes: A61K 49/227 Liposomes, lipoprotein vesicles, e.g. LDL or HDL lipoproteins, micelles, e.g. phospholipidic or polymeric
• CPC Class Codes: A61K 9/1277 Processes for preparing; Proliposomes

Abstract

The present invention describes processes for the preparation of a lipid blend and a uniform filterable phospholipid suspension containing the lipid blend, such suspension being useful as an ultrasound contrast agent.

Claims

1. A composition comprising

1,2-dipalmitoyl-sn-glycero-3-phosphotidic acid, mono sodium salt (DPPA), 1,2-dipalmitoyl-sn-glycero-3-phosphatidylcholine (DPPC), and N-(methoxypolyethylene glycol 5000 carbamoyl)-1,2-dipalmitoyl-sn-glycero-3-phosphatidylethanolamine, mono sodium salt (MPEG5000-DPPE), present in a mole ratio of 10% to 82% to 8%, and in an amount of about 0.75 mg/mL;

sodium chloride;

glycerin, present in an amount of about 0.1 mL/mL;

propylene glycol, present in an amount of about 0.1 mL/mL;

water, and

perfluoropropane.