Mass spectrometer

• US 8,658,969 B2
• Filed: 03/05/2008
• Issued: 02/25/2014
• Est. Priority Date: 03/05/2008
• Status: Active Grant

• Current Assignee: Shimadzu Corporation
• Original Assignee: Shimadzu Corporation
• Inventors: Nishiguchi, Masaru
• Primary Examiner(s): Kim, Robert
• Assistant Examiner(s): Chang, Hanway
• Application Number:
  US12/920,306
• Publication Number:
  US 20110012017A1
• Time in Patent Office: 2,183 Days
• Field of Search: 250/281, 250/282, 250/288, 250/290
• US Class Current: 250/281
• CPC Class Codes: H01J 49/063 Multipole ion guides, e.g. quadrupoles, hexapoles
• CPC Class Codes: H01J 49/065 having stacked electrodes, e.g. ring stack, plate stack

Abstract

One virtual rod electrode (11) is composed by arraying a plurality of plate electrodes (111, . . . , 118) along an ion beam axis, and a quadrupole ion optical element (1) is constructed by arranging four virtual rod electrodes (11, 12, 13 and 14) around an ion beam axis C. A voltage-applying unit alternately applies two radio-frequency voltages having a phase difference of 180 degrees for each of the plate electrodes in one virtual rod electrode. By this voltage application, the quadrupole component of the radio-frequency electric field created within a space surrounded by the four virtual rod electrodes is decreased, while higher-order multipole components are increased. The quadrupole component yields high ion convergence and mass selectivity, while the higher-order components provide high ion transmission efficiency and ion acceptance. The general ion transport efficiency can be improved by appropriately adjusting the ion optical characteristics according to the installation environment of the ion optical system and the conditions before and after the ion optical system.

Claims

1. A mass spectrometer having an ion optical system for transporting ions to a next stage, which is characterized in that the ion optical system includes:

a) a virtual multipole rod ion optical element having 2×

N pieces of virtual rod electrodes where N is an integer equal to or greater than two, arranged so as to surround an ion beam axis, each virtual rod electrode being composed of M pieces of plate electrodes spaced along the ion beam axis where M is an integer equal to or greater than three; and

b) a voltage-applying means for applying radio-frequency voltages in a following manner;

in each set of the 2×

N plate electrodes arranged around the ion beam axis, a same radio-frequency voltage is applied to any two plate electrodes opposing each other across the ion beam axis, and two radio-frequency voltages having a same amplitude and a phase difference of 180 degrees are respectively applied to any two plate electrodes neighboring each other around the ion beam axis; and

in each set of the M plate electrodes forming one virtual rod electrode, a phase of the radio-frequency voltage applied to at least one of the plate electrodes is different from a phase of the radio-frequency voltage applied to another plate electrode.

2. The mass spectrometer according to claim 1, which is characterized in that the voltage-applying means applies a radio-frequency voltage having a same amplitude as that of the radio-frequency voltage applied to another plate electrode and a phase difference of 180 degrees, to at least one of the M pieces of the plate electrodes forming each virtual rod electrode.

3. The mass spectrometer according to claim 2, which is characterized in that radio-frequency voltages having a phase difference of 180 degrees are alternately applied for every group consisting of one or more of the plate electrodes neighboring each other along the ion beam axis at least in a part of the M-piece plate electrodes forming each virtual rod electrode.

4. The mass spectrometer according to claim 3, which is characterized in that the M pieces of the plate electrodes forming each virtual rod electrode include an electrode group in which the radio-frequency voltages having a phase difference of 180 degrees is alternately applied for every first number of plate electrodes neighboring each other along the ion beam axis, and another electrode group in which the radio-frequency voltages having a phase difference of 180 degrees is alternately applied for every second number of plate electrodes neighboring each other along the ion beam axis, where the second number differs from the first number.

5. The mass spectrometer according to claim 4, which is characterized in that N is 2.

6. The mass spectrometer according to claim 3, which is characterized in that that the M pieces of the plate electrodes forming each virtual rod electrode include an electrode group in which the radio-frequency voltages having a phase difference of 180 degrees are alternately applied for every predetermined number of plate electrodes neighboring each other along the ion beam axis, and another electrode group in which the same radio-frequency voltage is applied.

7. The mass spectrometer according to claim 6, which is characterized in that N is 2.

8. The mass spectrometer according to claim 6, which is characterized in that:

the voltage-applying means is configured so that the radio-frequency voltages having a phase difference of 180 degrees are alternately applied for each of the plate electrodes neighboring each other along the ion beam axis at least in a part of the M-piece plate electrodes forming each virtual rod electrode; and

M is equal to or greater than four.

9. The mass spectrometer according to claim 8, which is characterized by comprising an ion source for ionizing a sample component under approximately atmospheric pressure and a mass separator for separately detecting ions according to their mass under high vacuum, with one or more intermediate vacuum chambers provided between the ion source and the mass separator, the ion source communicating with the intermediate vacuum chamber next to it via either a small ion-passage hole or a thin ion-passage pipe, and the ion optical system being placed within this intermediate vacuum chamber.

10. The mass spectrometer according to claim 8, which is characterized by comprising a collision chamber placed under a high vacuum atmosphere, the collision chamber being used for dissociating an ion by bringing the ion into collision with a collision-induced dissociation gas supplied into the collision chamber, and the ion optical system being placed within this collision chamber.

11. The mass spectrometer according to claim 3, which is characterized in that N is 2.

12. The mass spectrometer according to claim 3, which is characterized in that:

the voltage-applying means is configured so that the radio-frequency voltages having a phase difference of 180 degrees are alternately applied for each of the plate electrodes neighboring each other along the ion beam axis at least in a part of the M-piece plate electrodes forming each virtual rod electrode; and

M is equal to or greater than four.

13. The mass spectrometer according to claim 12, which is characterized by comprising an ion source for ionizing a sample component under approximately atmospheric pressure and a mass separator for separately detecting ions according to their mass under high vacuum, with one or more intermediate vacuum chambers provided between the ion source and the mass separator, the ion source communicating with the intermediate vacuum chamber next to it via either a small ion-passage hole or a thin ion-passage pipe, and the ion optical system being placed within this intermediate vacuum chamber.

14. The mass spectrometer according to claim 12, which is characterized by comprising a collision chamber placed under a high vacuum atmosphere, the collision chamber being used for dissociating an ion by bringing the ion into collision with a collision-induced dissociation gas supplied into the collision chamber, and the ion optical system being placed within this collision chamber.

15. A mass spectrometer comprising:

an ion optical element having four or more even number of virtual rod electrodes, symmetrically arranged about and along an ion beam axis, each virtual rod electrode comprising three or more plate electrodes disposed in parallel to each other and spaced along the ion beam axis; and

a voltage generator for applying radio-frequency voltages to each pair of plate electrodes within a plane perpendicular to the ion beam axis, the pair opposing each other across the ion beam axis and residing respectively in a pair of virtual rod electrodes symmetrically disposed about the ion beam axis,

wherein, for the plate electrodes within a plane perpendicular to the ion beam axis, a same radio-frequency voltage with a first phase is applied to one pair of plate electrodes opposing each other across the ion beam axis, and a same radio-frequency voltage with a second phase with a 180 degree phrase difference from the first phase is applied to another pair of plate electrodes opposing each other across the ion beam axis and neighboring the previous one pair such that any neighboring pairs of plate electrodes within the same plane have the same radio-frequency voltage but with a 180 degree phase difference; and

wherein, within each virtual rod electrode with the plate electrodes disposed along the ion beam axis, a phase of the radio-frequency voltage applied to at least one of the plate electrodes is different from a phase of the radio-frequency voltage applied to another plate electrode.

16. The mass spectrometer according to claim 15, wherein, within each virtual rod electrode with the plate electrodes, the voltage generator applies to one plate electrode a radio-frequency voltage having a same amplitude as that of the radio-frequency voltage applied to another plate electrode but with a phase difference of 180 degrees.

17. The mass spectrometer according to claim 16, wherein, for at least a group of the plate electrodes within each virtual rod electrode, the radio-frequency voltages having a phase difference of 180 degrees are alternately applied to the plate electrodes neighboring each other along the ion beam axis.

18. The mass spectrometer according to claim 17, wherein, within each virtual rod electrode, for a first set of plate electrodes, the radio-frequency voltages having a phase difference of 180 degrees is alternately applied for every first number of plate electrodes neighboring each other along the ion beam axis;

and for a second set of plate electrodes, the radio-frequency voltages having a phase difference of 180 degrees is alternately applied for every second number of plate electrodes neighboring each other along the ion beam axis, where the second number differs from the first number.

19. The mass spectrometer according to claim 17, wherein within each virtual rod electrode, for a first set of plate electrodes, the radio-frequency voltages having a phase difference of 180 degrees are alternately applied for every predetermined number of plate electrodes neighboring each other along the ion beam axis;

and for a second set of plate electrodes, the same radio-frequency voltage is applied.

20. The mass spectrometer according to claim 17, wherein the voltage generator is configured so that the radio-frequency voltages having a phase difference of 180 degrees are alternately applied for each of the plate electrodes neighboring each other along the ion beam axis at least in a part of the four or more plate electrodes within each virtual rod electrode.