Methods and apparatus for the planning and delivery of radiation treatments
First Claim
1. A method for planning delivery of radiation dose to a target region within a subject, the method comprising:
- iteratively optimizing a simulated dose distribution relative to a set of one or more optimization goals over a preceding plurality of control points, the preceding plurality of control points located along a preceding trajectory which characterizes relative movement between a radiation source and a subject; and
upon reaching one or more preceding optimization termination conditions, iteratively optimizing a simulated dose distribution relative to the set of one or more optimization goals over an increased plurality of control points, the increased plurality of control points located along at least one subsequent trajectory which characterizes relative movement between the radiation source and the subject and the increased plurality of control points comprising a larger number of control points than the preceding plurality of control points.
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Accused Products
Abstract
Methods and apparatus are provided for planning and delivering radiation treatments by modalities which involve moving a radiation source along a trajectory relative to a subject while delivering radiation to the subject. In some embodiments the radiation source is moved continuously along the trajectory while in some embodiments the radiation source is moved intermittently. Some embodiments involve the optimization of the radiation delivery plan to meet various optimization goals while meeting a number of constraints. For each of a number of control points along a trajectory, a radiation delivery plan may comprise: a set of motion axes parameters, a set of beam shape parameters and a beam intensity.
97 Citations
20 Claims
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1. A method for planning delivery of radiation dose to a target region within a subject, the method comprising:
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iteratively optimizing a simulated dose distribution relative to a set of one or more optimization goals over a preceding plurality of control points, the preceding plurality of control points located along a preceding trajectory which characterizes relative movement between a radiation source and a subject; and upon reaching one or more preceding optimization termination conditions, iteratively optimizing a simulated dose distribution relative to the set of one or more optimization goals over an increased plurality of control points, the increased plurality of control points located along at least one subsequent trajectory which characterizes relative movement between the radiation source and the subject and the increased plurality of control points comprising a larger number of control points than the preceding plurality of control points. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 16)
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15. A method for planning delivery of radiation dose to a target region within a subject, the method comprising:
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iteratively optimizing a simulated dose distribution relative to a set of one or more optimization goals over a preceding plurality of control points, the preceding plurality of control points located along a preceding trajectory which characterizes relative movement between a radiation source and a subject; and upon reaching one or more preceding optimization termination conditions, iteratively optimizing a simulated dose distribution relative to the set of one or more optimization goals over an increased plurality of control points, the increased plurality of control points located along at least one subsequent trajectory which characterizes relative movement between the radiation source and the subject and the increased plurality of control points comprising a larger number of control points than the preceding plurality of control points wherein; the increased plurality of control points comprises two or more of the increased plurality of control points at a same spatial location along the at least one subsequent trajectory; and a first of the two or more of the increased plurality of control points is from among both the increased plurality of control points and the preceding plurality of control points and a second of the two or more of the increased plurality of control points is from among the increased plurality of control points but not from among the preceding plurality of control points.
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17. A method for planning delivery of radiation dose to a target region within a subject, the method comprising:
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iteratively optimizing a simulated dose distribution relative to a set of one of more optimization goals over a preceding plurality of control points; wherein, prior to iteratively optimizing the simulated dose distribution over the preceding plurality of control points, the preceding plurality of control points are located along a preceding trajectory which characterizes relative movement between a radiation source and a subject; and wherein iteratively optimizing the simulated dose distribution over the preceding plurality of control points comprises optimizing spatial locations of one or more of the preceding plurality of control points to thereby determine an optimized preceding trajectory. - View Dependent Claims (18, 19, 20)
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Specification