Small animal imaging capsule and bed system

• US 8,660,633 B2
• Filed: 05/06/2008
• Issued: 02/25/2014
• Est. Priority Date: 05/24/2007
• Status: Expired due to Fees

• Current Assignee: Koninklijke Philips Electronics N.V. (Koninklijke Philips N.V.)
• Original Assignee: Koninklijke Philips N.V.
• Inventors: Zagorchev, Lyubomir, Buckler, Andrew, Jean, Eric, Latto, Antonio T.
• Primary Examiner(s): Jung, Unsu
• Assistant Examiner(s): LAURITZEN, AMANDA L
• Application Number:
  US12/600,669
• Publication Number:
  US 20100198047A1
• Time in Patent Office: 2,121 Days
• Field of Search: 600/407, 600/410, 600/411, 600/414, 600/421, 600/425, 600/426, 600/427, 600/436, 560/0, 560/1
• US Class Current: 600/407
• CPC Class Codes: A61B 2503/40 Animals
• CPC Class Codes: A61B 5/4821 Determining level or depth of anaesthesia A61B5/1106 takes precedence
• CPC Class Codes: A61B 6/04 Positioning of patients; Tiltable beds or the like operating tables A61G13/00; operating chairs A61G15/00
• CPC Class Codes: A61B 6/0421 with immobilising means
• CPC Class Codes: A61B 6/045 with heating or cooling means
• CPC Class Codes: A61B 6/508 for non-human patients
• CPC Class Codes: A61B 6/5235 combining images from the same or different ionising radiation imaging techniques, e.g. PET and CT
• CPC Class Codes: A61B 6/541 involving acquisition triggered by a physiological signal
• CPC Class Codes: A61D 7/04 Devices for anaesthetising animals by gases or vapours; Inhaling devices

Abstract

In a small animal imaging system (10) at least one modality (12) and a docking station (36) are provided. The docking station (36) provides a workspace (47) and docking ports (48) for preparation and holding of anesthetized animals that are awaiting imaging. For the duplication of positions, a subject mold (26) is provided that holds the subject in a reproducible position on a subject bed (16). Vital signs monitoring is also provided for subjects awaiting scans. The bed (16) includes fiducials (28) to aid in registration of like modality images and different modality images. A capsule (14) can encapsulate a single bed (16), or for tandem imaging, the capsule can encapsulate multiple-bed configurations, such as two, three, or four beds (16). For better positioning and ease of user access, a positioner (34) positions the capsule (14) from the rear of the modality (12).

Claims

1. An imaging system comprising:

a plurality of imagers, and each imager is configured to acquire diagnostic imaging data of subjects in one of a plurality of animal capsules located in an imaging region of one of the imagers, and each imager having at least a first docking interface which connects to a uniform capsule interface of the one of the plurality of animal capsules during imaging;

a docking station adapted to prepare subjects for imaging in at least one of the plurality of imagers, the docking station including;

at least a second docking interface which is adapted to connect to the uniform capsule interface of the at least one of the plurality of animal capsules and hold the at least one of the plurality of animal capsules while each subject is secured in the at least one of the plurality of animal capsules,

an induction chamber adapted to hold and anesthetize the subjects before each subject is secured in the at least one of the plurality of animal capsules; and

wherein, each animal capsule of the plurality of animal capsules is adapted to enclose a plurality of subjects for simultaneous imaging in each of the plurality of imagers and includes;

at least two subject supports, each support adapted to support a sedated subject during preparation and imaging;

a removable cover adapted to encapsulate the at least two subject beds; and

the uniform capsule interface adapted to connect with the at least first docking interface of each imager and the at least second docking interface of the docking station.

2. The imaging system as set forth in claim 1, wherein the plurality of imaging scanners include at least one of a small animal PET scanner, CT scanner, SPECT scanner, or a MRI scanner, or a hybrid scanner containing at least two imaging modalities.

3. The imaging system as set forth in claim 1, wherein the docking station includes a post-anesthesia chamber adapted to hold an anesthetized animal after an imaging session to allow the animal to recover from anesthesia.

4. The imaging system as set forth co in claim 1, wherein the docking station includes a workspace configured to allow a user to prepare an anesthetized animal for imaging.

5. The imaging system as set forth in claim 1, wherein each subject support is a contoured support adapted to assist in positioning and image registration of an animal.

6. The imaging system as set forth in claim 1, wherein the animal capsule includes at least three subject supports and the at least three subject supports are enclosed by the removable cover.

7. The imaging system as set forth in claim 1, wherein each animal capsule includes:

at least one sensor integrated into the subject support for monitoring at least one biological function of the subject located on the subject support; and

wherein the uniform capsule interface includes electrical connections for facilitating communication of the at least one sensor with a monitoring device.

8. The imaging system as set forth in claim 1, wherein the uniform capsule interface of each animal capsule includes electrical connections and fluid connections.

9. The imaging system as set forth in claim 8, wherein each animal capsule includes a nosecone for each subject that is supplied by the fluid connections and adapted to keep an animal in an anesthetized state during imaging in the imagers, and adapted to hold in anticipation of imaging and connected to the docking station.

10. The imaging system as set forth in claim 1, wherein the subject support includes at least one sensor device adapted to measure at least one biological process of the animal during imaging while the at least one animal capsule is connected to one of the scanners, and during holding or preparation while the at least one animal capsule is connected to the docking station.

11. The imaging system as set forth in claim 10, further including:

an alarm system for alerting a user when at least one abnormal biological process of at least one subject in the at least one animal capsule is detected during imaging in the at least one imager, or holding while connected to the docking station.

12. The imaging system as set forth in claim 1, wherein the at least two subject supports include a heating element for controlling the environment within the capsule.

13. The imaging system as set forth in claim 12, wherein the heating element includes a tail warming portion adapted to warm the tail of the animal mounted to the support.

14. The imaging system as set forth in claim 1, wherein each subject support includes fiducials adapted to be imaged by at least one of the imaging scanners to aid in registration of images.

15. The imaging system as set forth in claim 14, wherein the fiducials are adapted to be imaged by the imaging scanners.

16. The imaging system as set forth in claim 1, wherein each of the imaging modalities further includes:

a positioner connected to the first docking interface for positioning the capsule in the imaging modality.

17. The imaging system as set forth in claim 16, wherein the positioner is adapted to position the capsule from behind the modality, relative to where a user attaches the capsule to the docking interface.

18. The imaging system as set forth in claim 1, wherein the subject support includes a registration system configured to aid in image registrations.

19. The imaging system as set forth in claim 18, wherein the registration system includes at least one of the subject supports contoured to conform to a natural disposition of the subject, to reproduce subject position across imaging scans.

20. The imaging system as set forth in claim 18, wherein the registration system includes a plurality of fiducials associated with each subject support arranged in a non-linear fashion adapted to be viewed by each of the imagers.

21. An imaging system comprising:

at least one animal capsule which includes;

a plurality of subject supports, each configured to support an anesthetized animal during imaging and preparation, each subject support including;

at least one sensor device that is configured to measure at least one biological process of the animal while it is mounted to the support;

electrical leads connected to the sensors and configured to supply the sensors with power and carry communication signals indicative of at least one biological process of each mounted animal;

a removable cover configured to enclose the plurality of subjects and the subject supports;

a uniform capsule interface configured to connect to the electrical leads and receive the communication signals indicative of the at least one biological process of each mounted animal;

at least one imaging module which includes a small animal scanner configured to acquire diagnostic imaging data of the subjects in an imaging region of the scanner and in the at least one animal capsule, the scanner having at least a first docking interface configured to connect to the uniform docking interface during imaging and receive the electrical signals indicative of the at least one biological process of each mounted animal to a monitoring device; and

a docking station configured to prepare the subjects for imaging in the imaging scanner, the docking station having at least a second docking interface configured to connect to the uniform docking interface during preparation and holding, and provide the communication signals indicative of the at least one biological process of each mounted animal to the monitoring device.

22. An imaging system comprising:

at least one imager configured to acquire diagnostic imaging data and generate diagnostic images of subjects simultaneously in an imaging region of the imager, the imager having at least a first docking interface;

a docking station configured to prepare subjects for imaging in the imager, the docking station including at least a second docking interface and an induction chamber configured for anesthetizing the subject before securing the subject in an at least one animal capsule; and

the at least one animal capsule being configured to enclose a plurality of subjects and interface with the first and second docking interfaces, and includes;

a plurality of subject supports, each subject support configured to support an anesthetized animal during imaging and preparation, and each subject support being contoured to the size and shape of the type of subject for securing subjects in reproducible subject positions to aid in inter-subject and intra-subject registrations; and

a removable cover configured to enclose the plurality of subject supports.

23. A method of imaging comprising:

anesthetizing a plurality of animal subjects;

affixing each of the animal subjects to an imaging subject support;

encapsulating the animal subjects and the bed with a cover forming an animal capsule with a uniform capsule interface;

connecting the uniform capsule interface of the animal capsule to a docking interface of a docking station;

providing vital signs monitoring of the animal subjects, anesthesia delivery, and waste gas removal while the animal capsule is docked to the docking station;

disconnecting the uniform capsule interface of the animal capsule from the docking interface of the docking station and connecting the uniform capsule interface of the capsule to a docking interface of an imaging scanner;

positioning the animal capsule within an imaging region of the scanner;

performing an imaging scan of the animal subjects within the animal capsule;

providing vital signs monitoring of the animal subjects, continued anesthesia delivery, and waste gas removal while the animal capsule is docked to the imaging scanner.

24. The method as set forth in claim 23, wherein continued anesthesia delivery and waste gas removal are provided through pneumatic connections located in the uniform capsule interface of the animal capsule, and vital signs monitoring is provided via electrical connections in the uniform capsule interface of the animal capsule.