Miniature spectrometer

• US 8,660,637 B2
• Filed: 01/24/2012
• Issued: 02/25/2014
• Est. Priority Date: 11/21/1996
• Status: Expired due to Fees

• Current Assignee: Boston Scientific Scimed (Boston Scientific Corporation)
• Original Assignee: Boston Scientific Scimed (Boston Scientific Corporation)
• Inventors: Crowley, Robert J
• Primary Examiner(s): Lamprecht, Joel
• Application Number:
  US13/357,112
• Publication Number:
  US 20130023774A1
• Time in Patent Office: 763 Days
• Field of Search: 600/407, 600/476, 600/477, 600/478
• US Class Current: 600/478
• CPC Class Codes: A61B 5/0075 by spectroscopy, i.e. measuring spectra, e.g. Raman spectroscopy, infrared absorption spectroscopy A61B5/0071 takes precedence
• CPC Class Codes: A61B 5/0084 for introduction into the body, e.g. by catheters A61B5/1459 takes precedence
• CPC Class Codes: A61B 5/6848 Needles
• CPC Class Codes: G01J 2003/1213 Filters in general, e.g. dichroic, band
• CPC Class Codes: G01J 3/0208 using focussing or collimating elements, e.g. lenses or mirrors; performing aberration correction
• CPC Class Codes: G01J 3/0259 Monolithic
• CPC Class Codes: G01J 3/36 Investigating two or more bands of a spectrum by separate detectors
• CPC Class Codes: G01N 2021/3166 using separate detectors and filters
• CPC Class Codes: G01N 21/25 Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
• CPC Class Codes: G01N 21/33 using ultraviolet light G01N21/39 takes precedence

Abstract

A miniaturized spectrometer is adapted for placement within a body near tissue to be characterized. The spectrometer includes a light source and a plurality of light detectors. The light source generates light to illuminate the tissue. The detectors detect optical signals from the illuminated tissue and convert these optical signals to electrical signals. The miniaturized spectrometer can be disposed at the distal end of an interventional device. Optical conduits, such as fiber optic cables or strands, extending the length of the interventional device are not required when the miniature spectrometer is employed.

Claims

1. A tissue spectroscopy device for use with an interventional device, comprising:

a spectrometer module including;

a light source having a distal facing, light-emitting output end;

a plurality of light detectors arranged distally of the light source, wherein an output end face of each of the plurality of light detectors is arranged along an axis transverse to a longitudinal axis of the spectrometer module; and

an optically non-linear member positioned distally of the light source and configured to amplify a frequency of light emitted from the output end;

wherein the spectrometer module is selectively detachable from the interventional device during operation.

2. The tissue spectroscopy device of claim 1, wherein each of the plurality of light detectors includes a filter thereon so as to produce a plurality of frequency-selective light detectors.

3. The tissue spectroscopy device of claim 2, wherein each of the frequency-selective light detectors is configured to detect different ranges of light wavelengths.

4. The tissue spectroscopy device of claim 1, further including:

a ring holder configured to maintain the position of the optically non-linear member relative to the light source.

5. The tissue spectroscopy device of claim 1, wherein the optically non-linear member is bonded to the output end of the light source.

6. The tissue spectroscopy device of claim 1, wherein the optically non-linear member comprises a potassium dihydrogen phosphate (KDP) crystal.

7. The tissue spectroscopy device of claim 6, wherein the KDP crystal is coated with a fluoride layer.

8. The tissue spectroscopy device of claim 1, further including:

a lens configured to focus light emitted from the output end of the light source.

9. A tissue spectroscopy device, comprising:

an interventional device;

a spectrometer module including;

a light source having a distal facing light emitting output end;

a plurality of light detectors arranged distally of the light source; and

an optically non-linear member positioned distally of the light source and configured to amplify a frequency of light emitted from the output end; and

an optically transparent distal tip, wherein the spectrometer module is configured to be disposed within the optically transparent distal tip;

wherein the optically transparent distal tip includes a fluid channel configured to fluidly communicate a substance from the interventional device through a distal end of the optically transparent distal tip.

10. The tissue spectroscopy device of claim 9, wherein the spectrometer module is rotatable relative to the optically transparent distal tip so as to produce variations in an optical pathway.

11. The tissue spectroscopy device of claim 9, wherein the optically transparent distal tip includes a dissolvable material.

12. The tissue spectroscopy device of claim 9, wherein each of the plurality of light detectors includes a filter thereon so as to produce a plurality of frequency-selective light detectors.

13. The tissue spectroscopy device of claim 12, wherein each of the frequency-selective light detectors is configured to detect different ranges of light wavelengths.

14. The tissue spectroscopy device of claim 9, wherein each of the plurality of light detectors is arranged along an axis transverse to a longitudinal axis of the spectroscopy module.

15. The tissue spectroscopy device of claim 9, wherein the optically transparent distal tip is configured to pierce tissue of a patient.

16. A tissue spectroscopy device configured for insertion within tissue of a patient, comprising:

a spectrometer module including;

a light source having a distal facing light emitting output end;

a plurality of light detectors arranged distally of the light source, wherein an output end face of each of the plurality of light detectors is arranged along an axis transverse to a longitudinal axis of the spectrometer module; and

an optically non-linear member positioned distally of the light source and configured to amplify a frequency of light emitted from the output end; and

an optically transparent distal tip configured to penetrate tissue of a patient.

17. The tissue spectroscopy device of claim 16, wherein the spectrometer module is configured to be disposed within the optically transparent distal tip.

18. The tissue spectroscopy device of claim 17, wherein the spectrometer module is rotatable relative to the optically transparent distal tip so as to produce variations in an optical pathway.

19. The tissue spectroscopy device of claim 16, further comprising:

an interventional device, wherein the optically transparent distal tip includes a fluid channel configured to fluidly communicate a substance from the interventional device through a distal end of the optically transparent distal tip.

20. The tissue spectroscopy device of claim 16, wherein the optically non-linear member comprises a potassium dihydrogen phosphate (KDP) crystal coated with a fluoride layer.