Mapping ultrasound transducers

• US 8,661,873 B2
• Filed: 10/14/2010
• Issued: 03/04/2014
• Est. Priority Date: 10/14/2009
• Status: Active Grant

• Current Assignee: InSightec Ltd.
• Original Assignee: InSightec Ltd.
• Inventors: Medan, Yoav, Hertzberg, Yoni, Maor, Dov
• Primary Examiner(s): NOLAND, THOMAS
• Application Number:
  US12/904,655
• Publication Number:
  US 20110094288A1
• Time in Patent Office: 1,237 Days
• Field of Search: 73/18.2, 73/18.6, 324/307
• US Class Current: 73/1.86
• CPC Class Codes: A61B 8/587 Calibration phantoms models for medical purposes G09B23/28
• CPC Class Codes: A61N 2007/0078 with multiple treatment transducers
• CPC Class Codes: A61N 2007/0095 by modifying an excitation signal
• CPC Class Codes: G01H 17/00 Measuring mechanical vibrations or ultrasonic, sonic or infrasonic waves, not provided for in the preceding groups see provisionally also G01H1/00
• CPC Class Codes: G01N 29/30 Arrangements for calibrating or comparing, e.g. with standard objects
• CPC Class Codes: G10K 11/346 using phase variation

Abstract

Ultrasound transducers may be mapped by varying a focus-affecting parameter and adjusting the parameter so as to improve focus quality. In some embodiments, mapping involves successively varying the phase of one transducer element, or group of elements, with respect to a constant phase of the other transducer elements, and determining the phase at which a tissue displacement in the ultrasound focus is maximized.

Claims

1. A method for mapping an ultrasound transducer comprising a plurality of transducer elements so as to improve a focus thereof, the method comprising:

(a) driving the plurality of transducer elements so as to generate an ultrasound focus;

(b) varying a phase associated with a selected one of the transducer elements while driving the other transducer elements at a constant phase and measuring a resulting variation on a displacement associated with the focus using magnetic-resonance (MR) acoustic radiation force imaging; and

(c) selecting a value of the varied phase that is associated with a best focus quality by determining a phase difference, if any, between the constant and varied phases where the displacement is maximized and, if the phase difference is non-zero, adjusting a relative phase of the selected transducer element based thereon.

2. The method of claim 1 further comprising scanning a profile of the focus.

3. The method of claim 1 further comprising measuring a size of a cross-section of the focus.

4. The method of claim 1 further comprising measuring an integral intensity of the focus.

5. The method of claim 1 further comprising measuring a peak intensity of the focus.

6. The method of claim 1 wherein the acoustic radiation force imaging comprises applying a sequence of MR field gradients.

7. The method of claim 6 wherein the sequence of MR field gradients comprises repeated bipolar gradients.

8. The method of claim 6 wherein step (a) comprises generating an ultrasound pulse synchronized with the sequence of MR field gradients.

9. The method of claim 1 further comprising repeating steps (b) and (c) for the remaining transducer elements.

10. The method of claim 1 further comprising the step of providing a phantom, the driving step generating an ultrasound focus in the phantom and the measuring step measuring a focus quality in the phantom.

11. The method of claim 10 wherein the phantom comprises a material having low tensile strength.

12. The method of claim 11 wherein the phantom comprises a material having a small elastic modulus.

13. A method for controlling an ultrasound transducer comprising a plurality of transducer elements, the method comprising:

(a) mapping the ultrasound transducer by (i) driving the plurality of transducer elements so as to generate an ultrasound focus in a phantom, (ii) varying a focus-affecting parameter associated with at least one of the elements and measuring a resulting variation on a quality of the focus using magnetic-resonance acoustic radiation force imaging, and (iii) selecting a value of the parameter associated with a best focus quality; and

(b) controlling the transducer based on the mapping step so as to focus ultrasound into internal body tissue.

14. The method of claim 13 wherein controlling the transducer comprises driving the elements to produce outputs converging at a focus corresponding to a target treatment region.

15. The method of claim 13 further comprising, following step (b), repeating the mapping step.

16. The method of claim 13 wherein substep (ii) comprises, for each of the transducer elements, determining a relative phase associated with the transducer element by (1) driving the transducer element at a variable phase while driving the other transducer elements at a constant phase, thereby varying the focus quality, and (2) determining a phase difference, if any, between the constant and variable phases where the focus quality is optimized.

17. The method of claim 13, wherein the focus quality is measured using acoustic radiation force imaging to measure a displacement associated with the focus.