Magnetic nanoparticle and group of nanoparticles

• US 8,662,085 B2
• Filed: 02/28/2011
• Issued: 03/04/2014
• Est. Priority Date: 03/02/2010
• Status: Active Grant

• Current Assignee: Siemens Healthcare GMBH (Siemens AG)
• Original Assignee: Siemens AG
• Inventors: Maschke, Michael
• Primary Examiner(s): MATTHEWS, CHRISTINE HOPKINS
• Application Number:
  US13/036,065
• Publication Number:
  US 20110218380A1
• Time in Patent Office: 1,100 Days
• Field of Search: 128/899, 600 9- 15, 600/411, 424/9.322
• US Class Current: 128/899
• CPC Class Codes: A61K 2035/124 the cells being hematopoietic, bone marrow derived or blood cells
• CPC Class Codes: A61K 49/0409 Physical forms of mixtures of two different X-ray contrast-enhancing agents, containing at least one X-ray contrast-enhancing agent which is not a halogenated organic compound
• CPC Class Codes: A61K 9/0009 involving or responsive to electricity, magnetism or acoustic waves; Galenical aspects of sonophoresis, iontophoresis, electroporation or electroosmosis microelectromechanical systems A61K9/0097
• CPC Class Codes: A61K 9/5094 Microcapsules containing magnetic carrier material, e.g. ferrite for drug targeting
• CPC Class Codes: A61K 9/5115 Inorganic compounds
• CPC Class Codes: A61K 9/5138 obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
• CPC Class Codes: A61K 9/5146 obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyamines, polyanhydrides
• CPC Class Codes: A61M 5/007 for contrast media
• CPC Class Codes: A61P 9/00 Drugs for disorders of the cardiovascular system
• CPC Class Codes: B82Y 5/00 Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
• CPC Class Codes: C12N 11/00 Carrier-bound or immobilised enzymes; Carrier-bound or immobilised microbial cells; Preparation thereof
• CPC Class Codes: C12N 11/14 Enzymes or microbial cells immobilised on or in an inorganic carrier

Abstract

For particularly effective stem cell therapy a nanoparticle is provided. The nanoparticle has a first element consisting of a magnetic material, a support or envelope element consisting of a biodegradable material, a first substance containing an x-ray contrast agent, and a second substance containing stem cells. The stem cells are embodied such that they can be used for angiogenesis or for myogenesis.

Claims

1. A group of nanoparticles containing at least three nanoparticles, wherein each nanoparticle comprising:

a first element consisting of a magnetic core element;

a support element consisting of a biodegradable material;

a first substance containing an x-ray contrast agent; and

a second substance containing a stem cell to be used for angiogenesis or myogenesis,

wherein the magnetic core element, the x-ray contrast agent and the stem cell are arranged inside the support element,

wherein the support element is an envelope enclosing the first element, the first substance, and the second substance.

2. The group of nanoparticles as claimed in claim 1, wherein each nanoparticle has an average diameter between 5 nm and 300 nm.

3. The group of nanoparticles as claimed in claim 1, wherein the first substance comprises iodine or barium sulfate.

4. The group of nanoparticles as claimed in claim 1, wherein the stem cell comprises myoblasts.

5. The group of nanoparticles as claimed in claim 1, wherein the first element comprises ferric oxide or ferrous oxide.

6. The group of nanoparticles as claimed in claim 1, wherein the support element comprises a polymer, or a polyethyleneglycol, or a polyacrylate, or a polyoxide.

7. A method for positioning a group of nanoparticles, comprising:

positioning a catheter containing the group of nanoparticles at an intended treatment location in a living being;

injecting the group of nanoparticles into the living being; and

arranging a magnetic field generated outside the living being in a region of the treatment location for holding the group of nanoparticles at the treatment location,

wherein the group of nanoparticles comprises at least three nanoparticles,

wherein each nanoparticle comprises a magnetic core element, a support element, an x-ray contrast agent, and a stem cell to be used for angiogenesis or myogenesis, and

wherein the magnetic core element, the x-ray contrast agent and the stem cell are arranged inside the support element and are concentrated at the treatment location by the magnetic field until the stem cell is diffused through the support element,

wherein the support element is an envelope enclosing the magnetic core element, the x-ray contrast agent, and the stem cell.

8. The method as claimed in claim 7, further comprising taking an x-ray recording before and/or after the injection of the group of nanoparticles.