Device, system and method for in-vivo analysis

• US 8,663,093 B2
• Filed: 04/10/2007
• Issued: 03/04/2014
• Est. Priority Date: 04/03/2006
• Status: Active Grant

• Current Assignee: Given Imaging Limited (Medtronic Plc)
• Original Assignee: Given Imaging Limited (Medtronic Plc)
• Inventors: Rabinovitz, Elisha, Katz, Emil-Israel
• Primary Examiner(s): Smith, Philip R
• Assistant Examiner(s): BOLER, RYNAE E
• Application Number:
  US12/294,656
• Publication Number:
  US 20090318766A1
• Time in Patent Office: 2,520 Days
• Field of Search: 600/103, 600/117, 600/118, 600/160, 600/178, 600/300, 600/317
• US Class Current: 600/117
• CPC Class Codes: A61B 1/00016 using wireless means
• CPC Class Codes: A61B 1/00029 externally powered, e.g. wireless
• CPC Class Codes: A61B 1/041 Capsule endoscopes for imaging
• CPC Class Codes: A61B 1/043 for fluorescence imaging
• CPC Class Codes: A61B 5/0071 by measuring fluorescence emission
• CPC Class Codes: A61B 5/0084 for introduction into the body, e.g. by catheters A61B5/1459 takes precedence
• CPC Class Codes: A61B 5/073 Intestinal transmitters

Abstract

An in-vivo imaging device, typically an autonomous capsule, having a housing, the housing comprising a window; an illumination source located within the housing to illuminate a body lumen through the window; an imager to receive light reflected from the body lumen through the window; and a transmitter to transmit image data to a receiving system. The window is coated with liposomes containing a marker such that the imager may acquire images which include the marking.

Claims

1. An in-vivo imaging device comprising:

a housing, said housing comprising a window coated with a first and second type of rupturable liposomes, each of said rupturable liposomes containing a signaling marker, wherein the first type of rupturable liposomes rupture in the presence of a first target analyte and the second type of rupturable liposomes rupture in the presence of a second target analyte, thereby releasing said signaling markers from said first and second types of rupturable liposomes and resulting in a modification of an optical property of said signaling markers;

an illumination source located within the housing to illuminate a body lumen through the window;

an imager to receive light reflected from the body lumen through the window; and

a transmitter to transmit image data to a receiving system.

2. The imaging device according to claim 1, wherein the housing is capsule shaped.

3. The imaging device according to claim 1, wherein the imager acquires images including the modified optical property of said signaling marker.

4. The imaging device according to claim 1, wherein the rupturable liposomes are coated on an external portion of the window.

5. The imaging device according to claim 1, wherein the rupturable liposomes are immobilized in a carrier substance.

6. The imaging device according to claim 5, wherein the carrier substance is arranged as a band around a portion of the imaging device.

7. The imaging device according to claim 6, wherein the band further comprises a first area and at least a second area, wherein each area comprises a type of rupturable liposomes.

8. The imaging device according to claim 6, wherein the band further comprises a first area comprising said first type of rupturable liposomes and a second area comprising said second type of rupturable liposomes.