Ingestible devices for measuring physiological parameters

• US 8,663,105 B2
• Filed: 08/08/2009
• Issued: 03/04/2014
• Est. Priority Date: 08/11/2008
• Status: Active Grant

• Current Assignee: NXP B.V. (NXP Semiconductors NV)
• Original Assignee: NXP B.V. (NXP Semiconductors NV)
• Inventors: Malaurie, Jean-Marie, Droinet, Yvan Olivier Jean Ghislain, Stodel, Marc-Herve
• Primary Examiner(s): Thomson, Bill
• Assistant Examiner(s): Archer, Marie
• Application Number:
  US13/058,234
• Publication Number:
  US 20110295079A1
• Time in Patent Office: 1,669 Days
• Field of Search: None
• US Class Current: 600/300
• CPC Class Codes: A61B 5/0002 Remote monitoring of patients using telemetry, e.g. transmission of vital signals via a communication network A61B5/07 takes precedence; transmission systems for measured values G08C; transmission H04B; transmission of digital information H04L; wireless communication networks H04W
• CPC Class Codes: A61B 5/0008 Temperature signals
• CPC Class Codes: A61B 5/073 Intestinal transmitters
• CPC Class Codes: A61B 5/6861 Capsules, e.g. for swallowing or implanting
• CPC Class Codes: A61B 5/6871 Stomach
• CPC Class Codes: A61B 5/6873 Intestine
• CPC Class Codes: H02J 7/0031 using battery or load disconnect circuits H02J9/002 takes precedence
• CPC Class Codes: H02J 7/345 using capacitors as storage or buffering devices
• CPC Class Codes: Y10S 128/903 Radio telemetry
• CPC Class Codes: Y10S 977/904 for medical, immunological, body treatment, or diagnosis

Abstract

An ingestible apparatus produces and processes physiological signals representative of a physiological parameter. The apparatus measures the physiological parameter from within the body of a living entity. The apparatus includes a physiological transducer circuit to sense the physiological signals, a processor to process the physiological signals in response to the physiological transducer circuit, and a transmitter that transmits the processed signals during transmission intervals which are alternated with idle intervals. The apparatus further includes a capacitor-based circuit, including at least one capacitor, to accumulate sufficient charge during one of the idle intervals to supply power to the transmitter during one of the transmission intervals.

Claims

1. An ingestible apparatus for producing and processing physiological signals, the ingestible apparatus comprising:

a physiological transducer circuit configured to sense physiological signals representative of a physiological parameter measured from within a body of a living entity;

a processor, responsive to the physiological transducer circuit, that is configured to process the physiological signals to produce processed signals;

a transmitter configured to transmit the processed signals during transmission intervals which are alternated with idle intervals;

a capacitor-based circuit, including at least one capacitor, configured to accumulate sufficient charge during one of the idle intervals to supply power to the transmitter during one of the transmission intervals;

a power supply; and

startup circuitry responsive to an external RF signal configured to permit flow of charge from the power supply to the capacitor-based circuit.

2. The ingestible apparatus of claim 1, further comprising:

an encapsulation structure configured to secure therein the physiological transducer circuit, the processor, the transmitter, and the capacitor-based circuit.

3. The ingestible apparatus of claim 2, wherein the encapsulation structure is pill shaped and has outer dimensions of about 8 mm in diameter and about 17 mm in length.

4. The ingestible apparatus of claim 1, wherein the capacitor-based circuit includes a tank capacitor.

5. The ingestible apparatus of claim 1, further comprising:

an encapsulation structure configured to secure therein the physiological transducer circuit, the processor, the transmitter, and the capacitor-based circuit, wherein the capacitor-based circuit includes a tank capacitor.

6. The ingestible apparatus of claim 1, wherein the power supply includes a battery.

7. The ingestible apparatus of claim 1, wherein the transmission intervals are at least an order of magnitude shorter than the idle intervals.

8. The ingestible apparatus of claim 1, wherein the physiological transducer circuit senses the physiological parameter during the transmission intervals, the capacitor-based circuit further accumulating sufficient charge during one of the idle intervals to supply power to the physiological transducer circuit during one of the transmission intervals.

9. The ingestible apparatus of claim 1, wherein the apparatus is adapted to be swallowed by a human being.

10. The ingestible apparatus of claim 1, wherein the physiological transducer circuit includes a temperature sensor.

11. The ingestible apparatus of claim 1, wherein the physiological parameter is one of temperature, pressure, and pH.

12. The ingestible apparatus of claim 1, wherein the transmitter transmits communication bursts in accordance with a communication time schedule.

13. The ingestible apparatus of claim 12, wherein the communication time schedule is Time Division Multiple Access (TDMA).

14. The ingestible apparatus of claim 1, in which the startup circuit is arranged to prevent charging of the capacitor-based circuit and operation of the processor prior to activation of the apparatus.

15. The ingestible apparatus of claim 1, wherein the physiological transducer circuit and the transmitter are deactivated during the idle intervals.

16. A method for producing and communicating a physiological parameter measured from within a body of a living entity using an ingestible apparatus that includes a physiological transducer circuit that senses physiological signals representative of the physiological parameter, a processor that produces and processes the physiological signals, a transmitter, and a capacitor-based circuit, the method comprising:

sensing the physiological signals by measuring the physiological parameter from within the body of the living entity;

processing the physiological signals to produce processed signals;

powering the transmitter and transmitting the processed signals during transmission intervals during which the transmitter is powered by the capacitor-based circuit;

disabling the transmitter and charging the capacitor-based circuit responsive to an external RF signal during idle intervals that are alternated with the transmission intervals, the capacitor-based circuit accumulating sufficient charge from a power supply during one of the idle intervals to supply power to the transmitter during one of the transmission intervals; and

under control of the processor, shutting down the apparatus and returning it to a storage mode in which power consumption is fully stopped.

17. The method of claim 16, further comprising:

disabling the transmitter and the physiological transducer circuit during each of the idle intervals.

18. A system for producing and processing physiological signals, the system comprising:

a receiver unit; and

at least one ingestible apparatus that further comprises;

a physiological transducer circuit configured to sense physiological signals representative of a physiological parameter measured from within a body of a living entity;

a processor, responsive to the physiological transducer circuit, that is configured to process the physiological signals to produce processed signals;

a transmitter configured to transmit the processed signals during transmission intervals which are alternated with idle intervals; and

a capacitor-based circuit, including at least one capacitor, configured to accumulate sufficient charge during one of the idle intervals to supply power to the transmitter during one of the transmission intervals;

a power supply; and

startup circuitry responsive to an external RF signal arranged to permit flow of charge from the power supply to the capacitor-based circuit.

19. The system of claim 18, further comprising:

two or more of the ingestible apparatuses, each configured to sense respective physiological signals representative of respective physiological parameters.

20. The system of claim 19, wherein each of the two or more ingestible apparatuses is configured to transmit respective physiological signals according to different time schedules.

21. The system of claim 19, wherein each of the two or more ingestible apparatuses transmit a different apparatus identification.