Delivering light via optical waveguide and multi-view optical probe head

• US 8,666,209 B2
• Filed: 10/18/2011
• Issued: 03/04/2014
• Est. Priority Date: 04/24/2007
• Status: Active Grant

• Current Assignee: Samsung Electronics Co. Ltd.
• Original Assignee: Tomophase Corporation
• Inventors: Wang, Feiling, Vertikov, Andrey
• Primary Examiner(s): Lepisto, Ryan
• Assistant Examiner(s): BLEVINS, JERRY M
• Application Number:
  US13/276,281
• Publication Number:
  US 20120033911A1
• Time in Patent Office: 868 Days
• Field of Search: 385/11, 385/31, 385/33, 385/100, 385/109, 362/572, 362/574
• US Class Current: 385/33
• CPC Class Codes: A61B 5/0062 Arrangements for scanning
• CPC Class Codes: A61B 5/0066 Optical coherence imaging
• CPC Class Codes: A61B 5/0071 by measuring fluorescence emission
• CPC Class Codes: A61B 5/0075 by spectroscopy, i.e. measuring spectra, e.g. Raman spectroscopy, infrared absorption spectroscopy A61B5/0071 takes precedence
• CPC Class Codes: A61B 5/0084 for introduction into the body, e.g. by catheters A61B5/1459 takes precedence
• CPC Class Codes: A61B 5/6852 Catheters
• CPC Class Codes: A61N 5/0601 Apparatus for use inside the body
• CPC Class Codes: A61N 5/0603 for treatment of body cavities
• CPC Class Codes: A61N 5/062 Photodynamic therapy, i.e. excitation of an agent
• CPC Class Codes: G02B 23/2469 using optical fibres
• CPC Class Codes: G02B 26/108 having one or more prisms as scanning elements
• CPC Class Codes: G02B 27/283 used for beam splitting or combining
• CPC Class Codes: G02B 6/2713 cascade of polarisation selective or adjusting operations
• CPC Class Codes: G02B 6/274 based on light guide birefringence, e.g. due to coupling between light guides G02B6/105, G02B6/024 take precedence; mechanically induced birefringence G02F1/0134
• CPC Class Codes: G02B 6/2793 Controlling polarisation dependent loss, e.g. polarisation insensitivity, reducing the change in polarisation degree of the output light even if the input polarisation state fluctuates
• CPC Class Codes: G02B 6/32 having lens focusing means positioned between opposed fibre ends with lens being an integral part of the single fibre end G02B6/262
• CPC Class Codes: G02B 6/3604 Rotary joints allowing relative rotational movement between opposing fibre or fibre bundle ends

Abstract

Techniques, apparatus and systems that use an optical probe head to deliver light to a target and to collect light from the target for imaging, monitoring, medical diagnostics and medical treatment applications.

Claims

1. A method for imaging a target, comprising:

directing probe light from a proximal terminal of a fiber to a distal terminal of the fiber to interact with a target at or near the distal terminal of the fiber;

controlling optical polarization of the probe light to be at one of two different polarization directions when delivered to the target so that the probe light exits the fiber towards the target along a first beam direction when in a first polarization direction of the two different polarization directions and along a second, different beam direction when in a second polarization direction of the two different polarization directions;

controlling the optical polarization of the probe light at the target in the two different polarization directions at different times, respectively, to obtain optical image information of the target in a first region of the target when the probe light is controlled to be at the first polarization direction and to obtain optical image information of the target in a second region of the target when the probe light is controlled to be at the second polarization direction;

adjusting a position of the distal terminal of the fiber relative to the target to obtain optical images of the target at different positions along a longitudinal direction of the fiber;

operating a light director to direct the probe light from a light source into the proximal terminal of the fiber which guides the probe light to the distal terminal of the fiber at a target location in the first or second region of the target;

directing a first portion of the probe light at the distal terminal of the fiber to propagate away from the target location towards the proximal terminal o of the fiber without reaching the target location back into the fiber;

directing a second portion of the probe light at the distal terminal of the fiber to exit the fiber to reach the target location;

collecting reflected light from the target location caused by illumination of the second portion to direct the reflected light in the fiber to overlap with the first portion of the probe light and to co-propagate with the first portion of the probe light along the fiber towards proximal terminal of the fiber, wherein the reflected light from the target location carries optical image information of the target location;

using the light director to output light from the proximal terminal of the fiber, which includes the first portion of the probe light and the reflected light from the target location, along a common optical path to reach a detection module; and

operating the detection module to process the output light to obtain the optical image information of the target location.

2. The method as in claim 1, comprising:

adjusting a rotation angle of the probe beam around a rotation axis along the fiber to, in combination with adjusting a position of the distal terminal of the fiber at different positions along the fiber, to obtain three dimensional image information of the target.

3. The method as in claim 1, comprising:

selectively blocking light in one of the two polarization directions from reaching a target while directing light in the other of the two polarization directions to interact with the target; and

detecting returned light from the target to extract image information of the target.

4. The method as in claim 1, comprising:

operating the detection module to separate the output light into a first light beam and a second light beam;

subsequently varying a differential delay between the first light beam and the second light beam;

subsequent to varying the differential delay, combining the first light beam and the second light beam into combined light; and

processing the combined light to extract optical image information based on different differential delays.

5. The method as in claim 1, comprising:

operating a light source to produce source light;

splitting the source light from the light source into the probe light into the fiber for probing the target and a reference light beam along a reference optical arm that is separate from the fiber;

directing the reference light beam in the reference optical arm to a reference reflector to reflect the reference light beam back to the reference optical arm;

controlling a delay in the reflected reference light beam to produce varying values of the delay;

combining the reflected reference light beam from the reference optical arm and returned probe light from the fiber which carries optical image information of the target location to cause optical interference between the reflected reference light beam from the reference optical arm and returned probe light from the fiber to produce an optical interference signal as a function of the varying values of the delay in the reference light beam; and

processing the optical interference signal to extract the optical image information at the target location.

6. A method for imaging a target, comprising:

directing probe light from a proximal terminal of a fiber to a distal terminal of the fiber to interact with a target at or near the distal terminal of the fiber;

controlling optical polarization of the probe light to be at one of two different polarization directions when delivered to the target so that the probe light exits the fiber towards the target along a first beam direction when in a first polarization direction of the two different polarization directions and along a second, different beam direction when in a second polarization direction of the two different polarization directions;

controlling the optical polarization of the probe light at the target in the two different polarization directions at different times, respectively, to obtain optical image information of the target in a first region of the target when the probe light is controlled to be at the first polarization direction and to obtain optical image information of the target in a second region of the target when the probe light is controlled to be at the second polarization direction; and

adjusting a position of the distal terminal of the fiber relative to the target to obtain optical images of the target at different positions along a longitudinal direction of the fiber operating a light director to direct the probe light from a light source into the proximal terminal of the fiber which guides the probe light to the distal terminal of the fiber at a target location in the first or second region of the target;

directing a first portion of the probe light at the distal terminal of the fiber to propagate away from the target location towards the proximal terminal o of the fiber without reaching the target location back into the fiber;

directing a second portion of the probe light at the distal terminal of the fiber to exit the fiber to reach the target location;

collecting reflected light from the target location caused by illumination of the second portion to direct the reflected light in the fiber to overlap with the first portion of the probe light and to co-propagate with the first portion of the probe light along the fiber towards proximal terminal of the fiber, wherein the reflected light from the target location carries optical image information of the target location;

using the light director to output light from the proximal terminal of the fiber, which includes the first portion of the probe light and the reflected light from the target location, along a common optical path to reach a detection module; and

operating the detection module to modulate a differential delay between the first portion of the probe light and the reflected light from the target location to detect combined light of the first portion of the probe light and the reflected light from the target location under the modulated differential delay to obtain the optical image information of the target location.