Capture confirmation for multi-site pacing

• US 8,666,490 B1
• Filed: 12/13/2012
• Issued: 03/04/2014
• Est. Priority Date: 12/13/2012
• Status: Active Grant

• Current Assignee: Pacesetter Incorporated (Abbott Laboratories Incorporated)
• Original Assignee: Pacesetter Incorporated (Abbott Laboratories Incorporated)
• Inventors: Ryu, Kyungmoo
• Primary Examiner(s): Wieland, Robert N
• Application Number:
  US13/714,256
• Time in Patent Office: 446 Days
• Field of Search: 607/28
• US Class Current: 607/28
• CPC Class Codes: A61N 1/3627 for treating a mechanical deficiency of the heart, e.g. congestive heart failure or cardiomyopathy
• CPC Class Codes: A61N 1/3684 for stimulating the heart at multiple sites of the ventricle or the atrium
• CPC Class Codes: A61N 1/36842 Multi-site stimulation in the same chamber
• CPC Class Codes: A61N 1/3712 Auto-capture, i.e. automatic adjustment of the stimulation threshold

Abstract

A medical device includes pacing circuitry configured to deliver during a cardiac cycle a first pacing pulse to a first site using a first electrode as a cathode electrode for the first pacing pulse and to deliver a second pacing pulse to a second site using a second electrode as a cathode electrode for the second pacing pulse. Sensing circuitry is configured to generate a differential signal between cardiac electrical activity sensed at the first electrode and cardiac electrical activity sensed at the second electrode. Capture circuitry discriminates between single site capture and multi-site capture based on the differential signal.

Claims

1. A medical device, comprising:

implantable electrodes including at least a first electrode configured to be disposed at a first site of a heart chamber and a second electrode configured to be disposed at a second site of the heart chamber;

pacing circuitry configured to deliver a first pacing pulse to the first site using the first electrode as a cathode electrode for the first pacing pulse and to deliver a second pacing pulse to the second site using the second electrode as a cathode electrode for the second pacing pulse, the first pacing pulse and the second pacing pulse delivered during a cardiac cycle;

sensing circuitry configured to sense a cardiac response to the pacing pulses including sensing cardiac electrical activity using the implantable electrodes, the sensing circuitry further configured to generate a differential signal between sensed cardiac electrical activity at the first electrode and sensed cardiac electrical activity at the second electrode; and

capture circuitry configured to discriminate between single site capture, comprising capture by one of the first pacing pulse or the second pacing pulse, and multi-site capture, comprising capture by both the first pacing pulse and the second pacing pulse, based on the differential signal.

2. The medical device of claim 1, wherein the capture circuitry is configured to discriminate between single site capture and multi-site capture based on one or both of amplitude and morphology of the differential signal.

3. The medical device of claim 1, wherein the capture circuitry is configured to:

discriminate between single site capture and multi-site capture based on one or both of amplitude and morphology of the differential signal; and

confirm single site capture or confirm multi-site capture by comparison of the differential signal to at least one additional signal, the at least one additional signal predominantly comprising a captured response signal produced by the first pacing pulse and sensed at the first pacing site.

4. The medical device of claim 1, wherein:

the sensing circuitry is configured to generate at least one additional signal, the additional signal predominantly comprising a captured response signal produced by the first pacing pulse and sensed between the first electrode and a third electrode; and

the capture circuitry is configured to compare the differential signal to the additional signal and to discriminate between single site capture and multi-site capture based on comparison between the differential signal and the additional signal.

5. The medical device of claim 4, wherein the third electrode comprises an electrode disposed on an implantable housing of the medical device.

6. The medical device of claim 5, wherein the third electrode is disposed in or on another heart chamber.

7. The medical device of claim 4, wherein the capture circuitry is configured to detect multi-site capture if an amplitude of the differential signal is a predetermined amount less than an amplitude of the additional signal or if a ratio between an amplitude of the differential signal and an amplitude of the additional signal is below an amplitude ratio threshold value.

8. The medical device of claim 4, wherein the capture circuitry is configured to detect multi-site capture if morphology of the differential signal is inconsistent with morphology of the additional signal.

9. The medical device of claim 1, wherein the capture circuitry is disposed within an implantable housing.

10. The medical device of claim 1, wherein the capture circuitry is disposed within a patent external device.

11. The medical device of claim 1, wherein the capture circuitry is configured to perform a capture threshold test to determine a capture threshold of the second site, the capture threshold test configured to:

deliver first and second pacing pulses to the first and second sites, respectively during multiple cycles of the capture threshold test,

maintain a pacing energy of the first pacing pulses above a capture threshold for the first site, and

step down or step up a pacing energy of the second pacing pulses until a change in capture status is detected,

wherein the change in capture status occurs if

multi-site capture is detected for a first cardiac cycle and single site capture is detected for one or more cardiac cycles following the first cardiac cycle when the energy of the second pacing pulses is stepped down during the capture threshold test, or

single site capture is detected for a first cardiac cycle and multi-site capture is detected for one or more cardiac cycles following the first cardiac cycle if the energy of the second pacing pulses is stepped up during the capture threshold test.

12. A medical device, comprising:

a plurality of electrodes configured to be respectively coupled to a heart chamber at a plurality of sites;

a pulse generator configured to deliver during a cardiac cycle;

a first pacing pulse using a first pacing cathode electrode of the plurality of electrodes, and

a second pacing pulse using a second pacing cathode electrode of the plurality of electrodes;

sensing circuitry comprising a first sensing electrode and a second sensing electrode, the sensing circuitry configured to sense a cardiac response to the pacing pulses, including sensing cardiac electrical activity at the first sensing electrode and at the second sensing electrode, the sensing circuitry further configured to develop a differential signal between cardiac electrical activity sensed at the first sensing electrode from cardiac electrical activity sensed at the second sensing electrode; and

capture circuitry configured to discriminate between single site capture by one of the first or second pacing pulses and multi-site capture by both the first and second pacing pulses based on the differential signal.

13. The device of claim 12, wherein the first sensing electrode is the first pacing cathode electrode and the second sensing electrode is the second pacing cathode electrode.

14. The device of claim 12, wherein the plurality of electrodes are disposed on a multi-electrode lead and the first sensing electrode comprises an electrode adjacent to the first pacing cathode electrode on the multi-electrode lead.

15. The medical device of claim 12, wherein the sensing circuitry comprises a differential amplifier having first and second differential inputs and the first sensing electrode is electrically coupled to the first differential input and the second sensing electrode is electrically coupled to the second differential input.

16. The medical device of claim 12, wherein the sensing circuitry comprises circuitry configured to develop the differential signal by subtracting a first signal comprising cardiac electrical activity sensed using the first sensing electrode from a second signal comprising cardiac electrical activity sensed using the second sensing electrode.

17. A method, comprising:

delivering a first pacing pulse to a first site of a cardiac chamber using a first electrode as a cathode electrode for the first pacing pulse;

delivering a second pacing pulse to a second site of the cardiac chamber using a second electrode as a cathode electrode for the second pacing pulse, the first and second pacing pulses delivered during a cardiac cycle;

sensing cardiac activity at the first and second electrodes;

generating a differential signal between the cardiac activity sensed at the first electrode and the cardiac activity sensed at the second electrode following delivery of the first and second pacing pulses;

determining capture status of the first and second pacing pulses including discriminating between single site capture by one of the first or second pacing pulses and multi-site capture by both the first and second pacing pulses based on the differential signal; and

modifying one or both of an energy of a subsequent first pacing pulse and an energy of a subsequent second pacing pulse based on the capture status.

18. The method of claim 17, further comprising generating at least one additional signal comprising cardiac activity sensed between one of the first or second electrodes and a third electrode, wherein discriminating between single capture and multi-site capture comprises comparing the differential signal to the additional signal.

19. The method of claim 17, wherein determining the capture status of the first and second pacing pulses comprises determining one or more of non capture by the first pacing pulse and non capture by the second pacing pulse.

20. The method of claim 17, wherein delivering the first pacing pulse and delivering the second pacing pulse comprises timing an intersite pacing delay between delivering the first pacing pulse and delivering the second pacing pulse.