Methods and apparatus for electrical treatment using balloon and electrode

• US 8,666,496 B2
• Filed: 02/17/2013
• Issued: 03/04/2014
• Est. Priority Date: 04/10/2008
• Status: Expired due to Fees

• Current Assignee: electroCore, Inc.
• Original Assignee: Electrocore, Llc
• Inventors: Simon, Bruce, Mendez, Steven, Hu, Hecheng, Dickerson, Richard P., Pastena, James R., Guo, Puyun
• Primary Examiner(s): Wieland, Robert N
• Application Number:
  US13/769,366
• Publication Number:
  US 20130204334A1
• Time in Patent Office: 380 Days
• Field of Search: 607/40, 607/42, 607/43, 607/137, 600/375
• US Class Current: 607/40
• CPC Class Codes: A61M 2025/105 having a balloon suitable for drug delivery, e.g. by using holes for delivery, drug coating or membranes
• CPC Class Codes: A61N 1/05 for implantation or insertion into the body, e.g. heart electrode A61N1/06 takes precedence
• CPC Class Codes: A61N 1/0517 Esophageal electrodes
• CPC Class Codes: A61N 1/0519 Endotracheal electrodes
• CPC Class Codes: A61N 1/0551 Spinal or peripheral nerve electrodes
• CPC Class Codes: A61N 1/36007 of urogenital or gastrointestinal organs, e.g. for incontinence control
• CPC Class Codes: A61N 1/3605 Implantable neurostimulators for stimulating central or peripheral nerve system
• CPC Class Codes: A61N 1/40 Applying electric fields by inductive or capacitive coupling microwave apparatus A61N5/00; Applying radio-frequency signals

Abstract

The present invention provides systems, apparatus and methods for selectively applying electrical energy to body tissue. A device is provided with an electrode positioned within the interior of an enclosure and a fluid passage coupled to the enclosure for delivery of an electrically conductive fluid such that the electrically conductive fluid. The conductive fluid allows for the passage of electrical energy from the electrode through the fluid and the outer wall of the enclosure for treatment of tissue on or in a patient. The electrode does not directly contact the tissue of the patient, which reduces the potential for collateral tissue damage or necrosis and/or excessive electric fields in the tissue.

Claims

1. A device for delivering energy to a mammal comprising:

a first enclosure having an outer wall surrounding an interior;

a second enclosure having an outer wall surrounding an interior;

a first electrode located within the interior of the first enclosure and spaced from the outer wall of the first enclosure;

a second electrode located within the interior of the second enclosure and spaced from the outer wall of the second enclosure; and

first and second fluid passages coupled to the interiors of the first and second enclosures, respectively, for delivery of an electrically conductive fluid to the interiors of the first and second enclosures, respectively, such that each of the first and second electrodes are electrically coupled to each of the outer walls of the first and second enclosures through the electrically conductive fluid.

2. The device of claim 1 further comprising an electrical signal generator operating to apply a voltage to the first and second electrodes such that electric current passes from the first electrode to the second electrode through tissue of the mammal.

3. The device of claim 1 wherein the outer walls of the first and second enclosures each have at least one section that is formed from an electrically-permeable material.

5. The device of claim 1 wherein the first and second electrodes are substantially centrally located within the first and second enclosures, respectively, in the inflated position.

6. The device of claim 3 wherein the first and second balloons are arranged such that an electric field created by the voltage is substantially parallel to an axis of a target tissue in the patient.

4. The device of 1 wherein the first and second enclosures are balloons movable between a deflated position for introduction into a patient and an inflated position for contacting tissue within the patient.

7. A method of treating an ailment comprising:

positioning first and second balloons adjacent to or in contact with a tissue structure having a longitudinal axis within or on a patient'"'"'s body, said first and second balloons having first and second electrodes located within an interior of the first and second balloons, respectively; and

applying an electric field to the first and second electrode(s) such that the electric field is substantially parallel to the longitudinal axis of the tissue structure.

8. The method of claim 7 wherein the tissue structure is a nerve fiber.

9. The method of claim 7 further comprising inflating said first and second balloons such that an outer surface of the balloons is adjacent to or in contact with the tissue structure.

10. The method of claim 9 wherein said inflation step is carried out by delivering electrically conductive fluid to the interior of the first and second balloons.

11. The method of claim 7 wherein the applying step is carried out by applying an electric signal across the first and second electrodes such that the electric field is substantially parallel to the tissue structure.