Double wall catheter for delivering therapeutic agent
First Claim
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1. A catheter assembly comprising:
- an inner expandable and collapsible structure, an outer expandable and collapsible structure, the inner and outer expandable and collapsible structures each being configured to expand between a contracted state and a dilated state;
the inner and outer expandable and collapsible structures defining a cavity therebetween, the cavity being configured to contain a benefit composition;
the outer expandable and collapsible structure defining openings, the openings being configured to be closed when the assembly is in the contracted state and open when the assembly is in the dilated state;
when open, the openings provide fluid communication from the cavity to surroundings of the assembly, wherein the outer expandable and collapsible structure comprises an expandable and contractible membrane and an inner photolinkable seal material scissile coating, an outer photolinkable seal material scissile coating, or both inner and outer photolinkable seal material scissile coatings, and in the dilated state, the openings extending through the scissile coating or coatings.
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Abstract
The present invention relates to a catheter assembly that can deliver a therapeutic composition. The catheter assembly can include an outer balloon with openings for releasing the therapeutic composition. When the catheter assembly is in its contracted state, the openings are closed, and the assembly retains the therapeutic composition. When the catheter assembly is in its dilated state, the openings are open, and the therapeutic composition is released. The present invention also includes methods of making and using such a catheter assembly.
58 Citations
21 Claims
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1. A catheter assembly comprising:
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an inner expandable and collapsible structure, an outer expandable and collapsible structure, the inner and outer expandable and collapsible structures each being configured to expand between a contracted state and a dilated state; the inner and outer expandable and collapsible structures defining a cavity therebetween, the cavity being configured to contain a benefit composition; the outer expandable and collapsible structure defining openings, the openings being configured to be closed when the assembly is in the contracted state and open when the assembly is in the dilated state;
when open, the openings provide fluid communication from the cavity to surroundings of the assembly, wherein the outer expandable and collapsible structure comprises an expandable and contractible membrane and an inner photolinkable seal material scissile coating, an outer photolinkable seal material scissile coating, or both inner and outer photolinkable seal material scissile coatings, and in the dilated state, the openings extending through the scissile coating or coatings. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19)
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20. A catheter assembly comprising:
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an inner expandable and collapsible structure, an outer expandable and collapsible structure, the inner and outer expandable and collapsible structures each being configured to expand between a contracted state and a dilated state; the inner and outer expandable and collapsible structures defining a cavity therebetween, the cavity being configured to contain a benefit composition; the outer expandable and collapsible structure defining openings, the openings being configured to be closed when the assembly is in the contracted state and open when the assembly is in the dilated state;
when open, the openings provide fluid communication from the cavity to surroundings of the assembly, wherein the outer expandable and collapsible structure comprises an expandable and contractible membrane and one or more photolinkable seal material scissile patches or plugs;
in the dilated state, an opening extending through a photolinkable seal material scissile patch or plug.
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21. A method of delivering a bioactive agent to a site in a body, the method comprising:
- placing at the site a catheter assembly comprising;
an inner expandable and collapsible structure, an outer expandable and collapsible structure, the inner and outer expandable and collapsible structures being configured to expand between a contracted state and a dilated state; the inner and outer expandable and collapsible structures defining a cavity therebetween, the cavity containing a benefit composition comprising a bioactive agent; the outer expandable and collapsible structure comprising openings, the openings being configured to be closed when the assembly is in the contracted state and open when the assembly is in the dilated state; when open, the openings provide fluid communication from the cavity to surroundings of the assembly;
actuating the catheter assembly from the contracted state to the dilated state to release the bioactive agent, wherein the outer expandable and collapsible structure comprises an expandable and contractible membrane and an inner photolinkable seal material scissile coating, an outer photolinkable seal material scissile coating, or both inner and outer photolinkable seal material scissile coatings, and in the dilated state, the openings extending through the scissile coating or coatings.
- placing at the site a catheter assembly comprising;
Specification