Method of preparing an antimicrobial packaged medical device

• US 8,668,867 B2
• Filed: 03/13/2012
• Issued: 03/11/2014
• Est. Priority Date: 10/04/2002
• Status: Expired due to Term

• Current Assignee: Ethicon Incorporated (Johnson & Johnson)
• Original Assignee: Ethicon Incorporated (Johnson & Johnson)
• Inventors: Scalzo, Howard, Fischer, Jerome A., Rothenburger, Stephen, Cerwin, Robert, McDivitt, James R.
• Primary Examiner(s): Yoo, Regina M
• Application Number:
  US13/419,377
• Publication Number:
  US 20120227360A1
• Time in Patent Office: 728 Days
• Field of Search: 422/28, 422/29
• US Class Current: 422/29
• CPC Class Codes: A61B 17/06114 Packages or dispensers for needles or sutures packages for sharps A61B50/3001; for dental floss A61C15/043; packages for needles in general B65D85/24
• CPC Class Codes: A61B 17/06166 Sutures suture materials A61L17/00; manufacture of artificial threads D01D; treatment of threads D06M
• CPC Class Codes: A61B 50/00 Containers, covers, furniture or holders specially adapted for surgical or diagnostic appliances or instruments, e.g. sterile covers drapes specially adapted for instruments A61B46/10
• CPC Class Codes: A61L 17/005 containing a biologically active substance, e.g. a medicament or a biocide
• CPC Class Codes: A61L 2300/202 with halogen atoms, e.g. triclosan, povidone-iodine
• CPC Class Codes: A61L 2300/404 Biocides, antimicrobial agents, antiseptic agents

Abstract

A method for making an antimicrobial suture comprising the steps of positioning an antimicrobial agent source within a package comprising an inner surface, said antimicrobial agent being selected from the group consisting of halogenated hydroxyl ethers, acyloxydiphenyl ethers, and combinations thereof; positioning a medical device within the package; and subjecting the package, the antimicrobial agent source and the medical device to time, temperature and pressure conditions sufficient to vapor transfer an effective amount of the antimicrobial agent from the antimicrobial agent source to the medical device, thereby substantially inhibiting bacterial colonization on the medical device.

Claims

1. A method of making an antimicrobial medical device comprising the steps of:

positioning a medical device and an antimicrobial agent source within a package comprising an inner surface, said antimicrobial agent being selected from the group consisting of halogenated hydroxyl ethers, acyloxydiphenyl ethers, and combinations thereof;

subjecting the package, the antimicrobial agent source and the medical device to time, temperature and pressure conditions sufficient to vapor transfer an effective amount of the antimicrobial agent from the antimicrobial agent source to the medical device, thereby substantially inhibiting bacterial colonization on the medical device.

2. The method of claim 1, where an effective amount of the antimicrobial agent is vapor transferred from the antimicrobial agent source to the inner surface of the package, thereby substantially inhibiting bacterial colonization on the package.

3. The method of claim 2, wherein the antimicrobial agent source is an antimicrobial agent-loaded reservoir.

4. The method of claim 2, wherein the antimicrobial agent source is positioned within the package.

5. The method of claim 2, where the antimicrobial agent source is on the inner surface of the package.

6. The method of claim 2, wherein the antimicrobial agent source is integral with one or more packaging components in the package or the package.

7. The method according to claim 1, wherein the medical device further comprises at least one active agent selected from the group consisting of a biocide, a disinfectant, an antiseptic, an antibiotic, an antimicrobial peptide, a lytic bacteriophage, a surfactant;

an adhesion blocker;

an oligonucleotide, an efflux pump inhibitors;

a photosensitive dye, an immune modulator and a chelator.

8. The method of claim 1, wherein the antimicrobial agent source is in a liquid form in a solvent.

9. A method for making an antimicrobial suture comprising the steps of:

positioning a suture and an antimicrobial agent source within a package, said antimicrobial agent being selected from the group consisting of halogenated hydroxyl ethers, acyloxydiphenyl ethers, and combinations thereof; and

subjecting the package, the suture and the antimicrobial agent source to time, temperature and pressure conditions sufficient to vapor transfer an effective amount of the antimicrobial agent from the antimicrobial agent source to the suture, thereby substantially inhibiting bacterial colonization on the suture.

10. The method of claim 9, where an effective amount of the antimicrobial agent is vapor transferred from the antimicrobial agent source to the inner surface of the package, thereby substantially inhibiting bacterial colonization on the package.

11. The method according to claim 9, wherein the suture further comprises at least one active agent selected from the group consisting of a biocide, a disinfectant, an antiseptic, an antibiotic, an antimicrobial peptide, a lytic bacteriophage, a surfactant;

an adhesion blocker;

an oligonucleotide, an efflux pump inhibitors;

a photosensitive dye, an immune modulator and a chelator.

12. The method of claim 9, wherein the antimicrobial agent source is in a liquid form in a solvent.