Regional oximetry analog front end

• US 8,670,810 B2
• Filed: 06/04/2010
• Issued: 03/11/2014
• Est. Priority Date: 06/05/2009
• Status: Active Grant

• Current Assignee: Nonin Medical Incorporated
• Original Assignee: Nonin Medical Incorporated
• Inventors: Isaacson, Philip O.
• Primary Examiner(s): LaBalle, Clayton E
• Assistant Examiner(s): REISNER, NOAM S
• Application Number:
  US12/794,420
• Publication Number:
  US 20100312080A1
• Time in Patent Office: 1,376 Days
• Field of Search: 600/323
• US Class Current: 600/323
• CPC Class Codes: A61B 5/14552 Details of sensors specially adapted therefor
• CPC Class Codes: H03F 2200/261 Amplifier which being suitable for instrumentation applications
• CPC Class Codes: H03F 3/087 with IC amplifier blocks H03F3/085 takes precedence
• CPC Class Codes: H03F 3/45475 using IC blocks as the active amplifying circuit

Abstract

An apparatus includes a first amplifier having a first input coupled to a first optical detector. The first amplifier includes a first output corresponding to a logarithm of the first input. The apparatus includes a second amplifier having a second input coupled to a second optical detector and having a second output corresponding to a logarithm of the second input. The apparatus includes a differential amplifier configured to amplify a difference between the first output and the second output.

Claims

1. An apparatus comprising:

a first amplifier having a first input coupled to a first optical detector and having a first output corresponding to a logarithm of the first input wherein the first input corresponds to light intensity along a first optical path through a tissue, the first optical detector on the first optical path;

a second amplifier having a second input coupled to a second optical detector and having a second output corresponding to a logarithm of the second input wherein the second input corresponds to light intensity along a second optical path through the tissue, the second optical detector on the second optical path and wherein the first optical path differs from the second optical path, wherein the light intensity corresponds to concentration of an absorbing species in the tissue; and

a differential amplifier having a differential output, the differential amplifier configured to amplify a difference between the first output and the second output and generate an output signal, the output signal provided at the differential output and the output signal corresponding to oxygenation of a region of the tissue.

2. The apparatus of claim 1 wherein the first optical detector is coupled to an inverting input of the first amplifier.

3. The apparatus of claim 1 wherein the second optical detector is coupled to an inverting input of the second amplifier.

4. The apparatus of claim 1 wherein at least one of the first amplifier and the second amplifier includes an operational amplifier.

5. The apparatus of claim 1 wherein at least one of the first amplifier and the second amplifier includes a feedback path having a transistor junction.

6. The apparatus of claim 1 wherein the first optical detector and the second optical detector are responsive to light intensity.

7. The apparatus of claim 1 wherein the first optical detector and the second optical detector are configured to provide a signal corresponding to light absorbance.

8. The apparatus of claim 1 wherein the first amplifier matches the second amplifier.

9. The apparatus of claim 1 wherein the first amplifier and the second amplifier are in a common package.

10. The apparatus of claim 1 wherein the differential output is coupled to a module, the module configured to determine a measure of a tissue characteristic.

11. The apparatus of claim 10 wherein the module is configured to determine a characteristic of blood in the tissue.

12. The apparatus of claim 10 wherein the module is configured to determine a measure of a chromophore.

13. The apparatus of claim 10 wherein the module is configured to determine a measure of hemoglobin.

14. The apparatus of claim 10 wherein the module is configured to determine a hemoglobin index corresponding to a ratio of tissue and blood.

15. The apparatus of claim 10 wherein the module includes a display.

16. A method comprising:

receiving a first signal from a first optical detector, the first signal corresponding to a first optical parameter for a tissue wherein the first optical parameter corresponds to light intensity along a first optical path through the tissue;

receiving a second signal from a second optical detector, the second signal corresponding to a second optical parameter for the tissue wherein the second optical parameter corresponds to light intensity along a second optical path through the tissue, wherein the first optical path differs from the second optical path, wherein the light intensity corresponds to concentration of an absorbing species in the tissue;

generating a first amplified output corresponding to a logarithm of the first signal;

generating a second amplified output corresponding to a logarithm of the second signal; and

generating a differential output using the first amplified output and the second amplified output, wherein the differential output corresponds to oxygenation of a region of the tissue.

17. The method of claim 16 wherein at least one of receiving the first signal or receiving the second signal includes receiving a measure of light absorbance.

18. The method of claim 16 wherein generating the first amplified output includes providing the first signal to an inverting input of an operational amplifier.

19. The method of claim 16 wherein generating the second amplified output includes providing the second signal to an inverting input of an operational amplifier.

20. The method of claim 16 wherein generating the first amplified output and generating the second amplified output includes providing the first signal and the second signal to a common package.

21. The method of claim 16 further including using the differential output to determine a measure of oximetry.

22. The method of claim 21 further including displaying the measure.

23. A system comprising:

a first optical detector configured to provide a first signal corresponding to a first optical property of a tissue wherein the first optical property corresponds to light intensity along a first optical path through the tissue;

a second optical detector configured to provide a second signal corresponding to a second optical property of the tissue wherein the second optical property corresponds to light intensity along a second optical path through the tissue, wherein the first optical path differs from the second optical path, wherein the light intensity corresponds to concentration of an absorbing species in the tissue;

a first amplifier to generate a first output corresponding to a logarithm of the first signal;

a second amplifier to generate a second output corresponding to a logarithm of the second signal;

a differential amplifier configured to generate a differential output corresponding to oxygenation of a region of the tissue and based on the first output and the second output; and

a display configured to provide a visible indication corresponding to the differential output.

24. The system of claim 23 wherein the first optical detector and the second optical detector are coupled to a sensor housing.

25. The system of claim 24 wherein the sensor housing is configured for regional oximetry.

26. The system of claim 23 wherein the first amplifier and the second amplifier are configured as a single package.

27. The system of claim 23 wherein at least one of the first amplifier and the second amplifier includes a feedback path having a transistor junction.

28. The system of claim 23 wherein the first amplifier matches the second amplifier.

29. The system of claim 23 wherein the visible indication corresponds to a measure of regional oximetry.