Systems and methods for applying scaling laws of tree structures
First Claim
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1. A method for diagnosing disease in a patient'"'"'s biological tree, the method comprising the steps of:
- obtaining a model biological tree;
using a processor to produce an image showing a vasculature of at least part of a patient'"'"'s biological tree, wherein the processor is operably connected to a storage medium capable of receiving and storing the image;
identifying a length of a patient vessel portion and a diameter of a patient stem vessel proximal to the vessel crown from the patient'"'"'s biological tree image;
calculating model resistance based upon at least a length of a model vessel portion and a diameter of a model stem vessel proximal to the vessel crown from the model biological tree image;
calculating patient resistance based upon at least the length of the patient vessel portion and the diameter of the patient stem vessel proximal to the vessel crown from the patient'"'"'s biological tree image; and
comparing the calculated model resistance to the calculated patient resistance to determine the extent of vessel and/or organ disease.
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Abstract
Methods are provided for determining flow resistance within at least a portion of a vessel, whereby at least a partial biological tree image is obtained and resistance is calculated therefrom based upon at least the length of a defined vessel portion and a diameter of a stem vessel at a location proximal to a vessel crown. Methods are also provided for determining vessel volume, whereby at least a partial biological tree image is obtained and cumulative crown volume is calculated based on at least the diameter and length of the stem segment.
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Citations
56 Claims
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1. A method for diagnosing disease in a patient'"'"'s biological tree, the method comprising the steps of:
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obtaining a model biological tree; using a processor to produce an image showing a vasculature of at least part of a patient'"'"'s biological tree, wherein the processor is operably connected to a storage medium capable of receiving and storing the image; identifying a length of a patient vessel portion and a diameter of a patient stem vessel proximal to the vessel crown from the patient'"'"'s biological tree image; calculating model resistance based upon at least a length of a model vessel portion and a diameter of a model stem vessel proximal to the vessel crown from the model biological tree image; calculating patient resistance based upon at least the length of the patient vessel portion and the diameter of the patient stem vessel proximal to the vessel crown from the patient'"'"'s biological tree image; and comparing the calculated model resistance to the calculated patient resistance to determine the extent of vessel and/or organ disease. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19)
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20. A method for diagnosing disease in a patient'"'"'s biological tree, the method comprising the steps of:
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obtaining a model biological tree; using a processor to produce an image showing a vasculature of at least part of a patient'"'"'s biological tree, wherein the processor is operably connected to a storage medium capable of receiving and storing the image; identifying a diameter of a patient stem segment and a length of a patient stem segment from the patient'"'"'s biological tree image; calculating model cumulative crown volume based upon at least a diameter of a model stem segment and a length of a model stem segment from the model biological tree; calculating patient cumulative crown volume based upon at least the diameter of the patient stem segment and the length of the patient stem segment the patient'"'"'s biological tree image; and comparing the calculated model cumulative crown volume to the calculated patient cumulative crown volume to determine the extent of vessel and/or organ disease. - View Dependent Claims (21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33)
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34. A system for diagnosing disease in a patient'"'"'s biological tree, the system comprising:
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a processor; a storage medium operably connected to the processor, the storage medium capable of receiving and storing data relative of measurements from a vasculature of a vessel; wherein the processor is operable to; obtain a model biological tree; using the processor to produce an image showing a vasculature of at least part of the patient'"'"'s biological tree; identify a length of a patient vessel portion and a diameter of a patient stem vessel proximal to the vessel crown from the patient'"'"'s biological tree image; calculate model resistance based upon at least a length of a model vessel portion and a diameter of a model stem vessel proximal to the vessel crown from the model biological tree image; calculate patient resistance based upon at least the length of the patient vessel portion and the diameter of the patient stem vessel proximal to the vessel crown from the patient'"'"'s biological tree image; and compare the calculated model resistance to the calculated patient resistance to determine the extent of vessel and/or organ disease. - View Dependent Claims (35, 36, 37, 38, 39, 40, 41, 42, 43, 44)
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45. A system for diagnosing disease in a patient'"'"'s biological tree, the system comprising:
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a processor; a storage medium operably connected to the processor, the storage medium capable of receiving and storing data relative of measurements from a vasculature of a vessel; wherein the processor is operable to; obtain a model biological tree; using the processor to produce an image showing a vasculature of at least part of a patient'"'"'s biological tree; identify a diameter of a patient stem segment and a length of a patient stem segment from the patient'"'"'s biological tree image; calculate model cumulative crown volume based upon at least a diameter of a model stem segment and a length of a model stem segment from the model biological tree; calculate a patient'"'"'s cumulative crown volume based upon at least the diameter of the patient stem segment and the length of the patient stem segment the patient'"'"'s biological tree image; and compare the calculated model cumulative crown volume to the calculated model cumulative crown volume to determine the extent of vessel and/or organ disease. - View Dependent Claims (46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56)
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Specification