Devices and methods for tissue engineering
First Claim
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1. A synthetic bone prosthesis comprising:
- intertangled bioactive glass fibers;
bonds between the intertangled bioactive glass fibers to form a rigid three-dimensional tissue scaffold;
the bioactive glass fibers having crystal phase;
pore space within the rigid three-dimensional tissue scaffold predetermined by volatile components, the volatile components being interspersed within the intertangled bioactive fibers and removed during the formation of the bonds; and
the crystal phase and the bonds formed using an exothermic reaction of the volatile componentswherein the pore space creates a porosity between 40% and 85% in the synthetic bone prosthesiswherein the intertangled bioactive glass fiber comprises a mixture of bioactive glass fiber having different compositionswherein the mixture of bioactive glass fiber having different compositions comprises a bioactive fiber having a first composition and a bioactive fiber having a second composition and wherein the bioglass fibers having a crystal phase is one of the bioactive fibers having a first composition and the bioactive fibers having a second composition.
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Abstract
A resorbable tissue scaffold fabricated from bioactive glass fiber forms a rigid three-dimensional porous matrix having a bioactive composition. Porosity in the form of interconnected pore space is provided by the space between the bioactive glass fiber in the porous matrix. Strength of the bioresorbable matrix is provided by bioactive glass that fuses and bonds the bioactive glass fiber into the rigid three-dimensional matrix. The resorbable tissue scaffold supports tissue in-growth to provide osteoconductivity as a resorbable tissue scaffold, used for the repair of damaged and/or diseased bone tissue.
65 Citations
8 Claims
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1. A synthetic bone prosthesis comprising:
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intertangled bioactive glass fibers; bonds between the intertangled bioactive glass fibers to form a rigid three-dimensional tissue scaffold; the bioactive glass fibers having crystal phase; pore space within the rigid three-dimensional tissue scaffold predetermined by volatile components, the volatile components being interspersed within the intertangled bioactive fibers and removed during the formation of the bonds; and the crystal phase and the bonds formed using an exothermic reaction of the volatile components wherein the pore space creates a porosity between 40% and 85% in the synthetic bone prosthesis wherein the intertangled bioactive glass fiber comprises a mixture of bioactive glass fiber having different compositions wherein the mixture of bioactive glass fiber having different compositions comprises a bioactive fiber having a first composition and a bioactive fiber having a second composition and wherein the bioglass fibers having a crystal phase is one of the bioactive fibers having a first composition and the bioactive fibers having a second composition. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8)
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Specification