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Devices and methods for tissue engineering

  • US 8,673,016 B2
  • Filed: 04/17/2012
  • Issued: 03/18/2014
  • Est. Priority Date: 07/10/2009
  • Status: Active Grant
First Claim
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1. A synthetic bone prosthesis comprising:

  • intertangled bioactive glass fibers;

    bonds between the intertangled bioactive glass fibers to form a rigid three-dimensional tissue scaffold;

    the bioactive glass fibers having crystal phase;

    pore space within the rigid three-dimensional tissue scaffold predetermined by volatile components, the volatile components being interspersed within the intertangled bioactive fibers and removed during the formation of the bonds; and

    the crystal phase and the bonds formed using an exothermic reaction of the volatile componentswherein the pore space creates a porosity between 40% and 85% in the synthetic bone prosthesiswherein the intertangled bioactive glass fiber comprises a mixture of bioactive glass fiber having different compositionswherein the mixture of bioactive glass fiber having different compositions comprises a bioactive fiber having a first composition and a bioactive fiber having a second composition and wherein the bioglass fibers having a crystal phase is one of the bioactive fibers having a first composition and the bioactive fibers having a second composition.

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