Methods for facilitating use of dimethyl sulfoxide (DMSO) by removal of same, related compounds, or associated odors

• US 8,673,061 B2
• Filed: 05/02/2011
• Issued: 03/18/2014
• Est. Priority Date: 09/12/2005
• Status: Active Grant

• Current Assignee: Abela Pharmaceuticals, Inc.
• Original Assignee: Abela Pharmaceuticals, Inc.
• Inventors: Cozean, Jesse, Cozean, Colette, Gonzales, Efrain, Jacob, Stanley W.
• Primary Examiner(s): LAWRENCE JR, FRANK M
• Application Number:
  US13/098,941
• Publication Number:
  US 20110203583A1
• Time in Patent Office: 1,051 Days
• Field of Search: 951/35, 951/37, 951/41, 961/34, 961/54, 128/200.24, 128/204.15, 128/205.12, 128/205.27, 128/206.21, 128/207.14, 423/244.01, 55D/IG.35, 55D/IG.33
• US Class Current: 95/135
• CPC Class Codes: A61K 31/10 Sulfides; Sulfoxides; Sulfones
• CPC Class Codes: A61M 16/0087 Environmental safety or protection means, e.g. preventing explosion
• CPC Class Codes: A61M 16/0093 by adsorption, absorption or filtration
• CPC Class Codes: A61M 16/06 Respiratory or anaesthetic masks
• CPC Class Codes: A61M 16/105 Filters A61M16/047, A61M16/22 take precedence; water traps A61M16/08
• CPC Class Codes: A61M 16/1055 bacterial
• CPC Class Codes: A61M 16/1065 in the expiratory path
• CPC Class Codes: A61M 16/1075 by influencing the temperature A61M16/1045 takes precedence
• CPC Class Codes: A61M 16/208 Non-controlled one-way valves, e.g. exhalation, check, pop-off non-rebreathing valves
• CPC Class Codes: A61M 2205/7527 liquophilic, hydrophilic
• CPC Class Codes: B01D 2251/70 Organic acids
• CPC Class Codes: B01D 2253/102 Carbon
• CPC Class Codes: B01D 2253/1124 Metal oxides
• CPC Class Codes: B01D 2253/202 Polymeric adsorbents
• CPC Class Codes: B01D 2253/206 Ion exchange resins
• CPC Class Codes: B01D 2253/25 Coated, impregnated or composite adsorbents
• CPC Class Codes: B01D 2253/304 Linear dimensions, e.g. particle shape, diameter
• CPC Class Codes: B01D 2253/306 Surface area, e.g. BET-specific surface
• CPC Class Codes: B01D 2253/308 Pore size
• CPC Class Codes: B01D 2255/104 Silver
• CPC Class Codes: B01D 2255/20761 : Copper
• CPC Class Codes: B01D 2257/306 : Organic sulfur compounds, e.g. mercaptans
• CPC Class Codes: B01D 2257/90 : Odorous compounds not provided for in groups B01D2257/00 - B01D2257/708
• CPC Class Codes: B01D 2257/91 : Bacteria; Microorganisms
• CPC Class Codes: B01D 2258/06 : Polluted air
• CPC Class Codes: B01D 2259/40098 : with other heating means
• CPC Class Codes: B01D 2259/4533 : for medical purposes
• CPC Class Codes: B01D 2259/4541 : for portable use, e.g. gas masks
• CPC Class Codes: B01D 53/0415 : Beds in cartridges
• CPC Class Codes: B01D 53/48 : Sulfur compounds
• CPC Class Codes: B01J 20/20 : comprising free carbon; comprising carbon obtained by carbonising processes
• CPC Class Codes: B01J 20/2805 : Sorbents inside a permeable or porous casing, e.g. inside a container, bag or membrane

Abstract

Several embodiments of the invention relate to methods for removing compositions comprising dimethyl sulfoxide (DMSO) or related compounds, or odors associated with same. In several embodiments, systems including activated carbon filters, adsorbents, odor adsorbing fabrics, masks, clean air members and clean air supply assemblies are provided in order to perform said methods. In some embodiments the systems and methods facilitating the treatment of traumatic brain injury, ischemic stroke, atherosclerosis, spinal cord trauma, and neurodegenerative illnesses with compositions comprising DMSO.

Claims

1. A method for reducing the concentration of a dimethyl sulfoxide (DMSO) metabolite having an undesired odor, comprising:

passing a DMSO metabolite through a breathing system in fluid communication with a subject,

wherein the breathing system comprises a first filter, a ventilator and a HEPA filter in fluid communication,

wherein the ventilator is configured for transporting moist air comprising said DMSO metabolite from a subject to an exhaust port,

wherein the HEPA filter is positioned between the subject and the filter,

wherein the first filter is positioned downstream of the HEPA filter,

wherein said first filter causes no more than a 10% decrease in air flow and no more than a 10% change in pressure in said ventilator,

wherein the first filter comprises an adsorber and at least one sieve screen,

wherein the adsorber comprises about 10 grams to about 100 grams of activated carbon,

wherein said at least one sieve screen is configured to allow said DMSO metabolite to flow through the first filter while containing the adsorber within the first filter, and

contacting the DMSO metabolite with the first filter to capture at least 75% of the DMSO metabolite, thereby reducing the concentration of said DMSO metabolite.

2. The method of claim 1, wherein said first filter causes no more than 5 mm Hg change in pressure in said ventilator.

3. The method of claim 1, wherein the at least one sieve screen comprises polyester.

4. The method of claim 3, wherein the at least one sieve screen comprises a polyester-based lofted material.

5. The method of claim 1, wherein the at least one sieve screen further comprises a tackifier applied to at least a portion of one side of the at least one sieve screen.

6. The method of claim 1, wherein the first filter is in fluid communication with a face mask.

7. The method of claim 1, wherein the first filter is in fluid communication with an endotracheal tube.

8. The method of claim 1, wherein, the ventilator further comprises an accessory in fluid-communication with the first filter, the filter placed downstream of the accessory.

9. The method of claim 8, wherein the accessory is a biological filter configured to reduce viruses or bacteria.

10. The method of claim 8, wherein the accessory is a liquid trap to remove liquid from the breathing system.

11. The method of claim 8, wherein the accessory is a heat sink configured to cool the breathing system.

12. The method of claim 1, wherein the adsorber further comprises copper oxide.

13. The method of claim 1, wherein said DMSO metabolites are produced by a subject receiving DMSO treatment.

14. The method of claim 1, further comprising positioning the breathing system in fluid communication with the lungs of said subject.

15. The method of claim 1, wherein said first filter captures at least 90% of the DMSO metabolite.

16. A method for reducing the concentration of a dimethyl sulfoxide (DMSO) metabolite having an undesired odor, comprising:

conveying a DMSO metabolite through a breathing system in fluid communication with a subject,

wherein the breathing system comprises a first filter, a ventilator and a HEPA filter in fluid communication,

wherein the ventilator is configured for transporting moist air comprising said DMSO metabolite from a subject to an exhaust port,

wherein the first filter comprises an adsorber and at least one sieve screen,

wherein said at least one sieve screen is configured to allow said DMSO metabolite to flow through the first filter while containing the adsorber within the first filter, and

wherein the at least one sieve screen comprises polyester,

reducing the concentration of said DMSO metabolite at least 75% by capturing said DMSO metabolite with said first filter.

17. The method of claim 16, wherein said DMSO metabolite is produced by a subject receiving DMSO treatment.

18. The method of claim 16, further comprising positioning the breathing system in fluid communication with the lungs of said subject.

19. The method of claim 16, wherein said first filter captures at least 90% of the DMSO metabolite.