Method of tissue repair using a composite material
First Claim
1. A method of tissue repair within the body of animals, comprising the steps of:
- providing a composite biocompatible hydrogel material comprising a porous polymer matrix and a calcium salt, said polymer matrix comprising a plurality of pores and providing a Young'"'"'s modulus of at least 10 GPa, and said calcium salt disposed in at least some of said pores, andinserting said hydrogel material into cartilage or bone tissue of an animal, wherein said hydrogel material supports cell colonization in vitro for autologous cell seeding, wherein said polymer comprises bacterial cellulose, and wherein said calcium salt consists essentially of calcium deficient hydroxyapatite disposed in said matrix in the form of crystals.
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Abstract
A composite biocompatible hydrogel material includes a porous polymer matrix, the polymer matrix including a plurality of pores and providing a Young'"'"'s modulus of at least 10 GPa. A calcium comprising salt is disposed in at least some of the pores. The porous polymer matrix can comprise cellulose, including bacterial cellulose. The composite can be used as a bone graft material. A method of tissue repair within the body of animals includes the steps of providing a composite biocompatible hydrogel material including a porous polymer matrix, the polymer matrix including a plurality of pores and providing a Young'"'"'s modulus of at least 10 GPa, and inserting the hydrogel material into cartilage or bone tissue of an animal, wherein the hydrogel material supports cell colonization in vitro for autologous cell seeding.
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Citations
2 Claims
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1. A method of tissue repair within the body of animals, comprising the steps of:
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providing a composite biocompatible hydrogel material comprising a porous polymer matrix and a calcium salt, said polymer matrix comprising a plurality of pores and providing a Young'"'"'s modulus of at least 10 GPa, and said calcium salt disposed in at least some of said pores, and inserting said hydrogel material into cartilage or bone tissue of an animal, wherein said hydrogel material supports cell colonization in vitro for autologous cell seeding, wherein said polymer comprises bacterial cellulose, and wherein said calcium salt consists essentially of calcium deficient hydroxyapatite disposed in said matrix in the form of crystals. - View Dependent Claims (2)
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Specification