Transdermal drug delivery method and system

• US 8,673,346 B2
• Filed: 05/10/2013
• Issued: 03/18/2014
• Est. Priority Date: 10/27/2003
• Status: Active Grant

• Current Assignee: Morningside Venture Investments Ltd. (Morningside Group Ltd.)
• Original Assignee: Chrono Therapeutics Inc.
• Inventors: Zumbrunn, Werner, DiPierro, Guy, Imanidis, Georgios, van De Venn, Hans Wernher
• Primary Examiner(s): Desai, Anand
• Assistant Examiner(s): MERCIER, MELISSA S
• Application Number:
  US13/892,006
• Publication Number:
  US 20130338645A1
• Time in Patent Office: 312 Days
• Field of Search: None
• US Class Current: 424/449
• CPC Class Codes: A61K 31/00 Medicinal preparations containing organic active ingredients
• CPC Class Codes: A61K 9/7023 Transdermal patches and similar drug-containing composite devices, e.g. cataplasms galenical aspects of iontophoretic devices A61K9/0009; microneedle arrays A61K9/0021; buccal patches A61K9/006
• CPC Class Codes: A61M 35/00 Devices for applying media, e.g. remedies, on the human body devices for handling toiletry or cosmetic substances A45D; absorbent pads, e.g. swabs, A61F13/15

Abstract

The invention concerns a transdermal delivery system for controlled dispensing of an active substance to and through a porous surface. A certain amount of fluid comprising at least one active substance and at least one solvent is dispensed into an administration reservoir. In the administration reservoir the at least one solvent is separated from the administration reservoir by a solvent recovery means such that the active substance achieves a certain level on an interface device which is permeable for the one active substance. Thereby the active substance is absorbable via diffusion from the interface device by a porous surface to be treated.

Claims

1. A method for transdermal administration of at least one active substance to a porous surface comprising:

(a) storing at least one active substance in at least one substance reservoir;

(b) storing at least one solvent, operable to solubilize or disperse the at least one active substance, in at least one solvent reservoir;

(c) dispensing a first portion of the at least one active substance from the at least one substance reservoir and dispensing a second portion of the at least one solvent from the at least one solvent reservoir to at least one administration reservoir forming a solution or dispersion of the at least one active substance;

(d) transferring the solution or dispersion of the at least one active substance from the at least one administration reservoir to at least one interface, wherein the interface is interposed between the administration reservoir and the porous surface;

(e) removing the at least one solvent from the at least one administration reservoir by at least one solvent removal element; and

delivering the solution or dispersion of the at least one active substance from the at least one interface to the porous surface.

2. The method of claim 1, wherein the at least one substance reservoir and the at least one solvent reservoir exist as a common reservoir.

3. The method of claim 1, wherein a propellant further propels the at least one active substance from the at least one substance reservoir and the at least one solvent from the at least one solvent reservoir into the at least one administration reservoir.

4. The method of claim 3, wherein the propellant is compressed gas.

5. The method of claim 1, wherein the at least one active substance is dispensed from the at least one substance reservoir to the at least one administration reservoir in response to a control signal.

6. The method of claim 1, wherein the interface comprises an adhesive surface suitable to be attached to the porous surface.

7. The method of claim 1, wherein the interface is a membrane permeable to the active substance.

8. The method of claim 1, wherein the at least one solvent is removed from the at least one administration reservoir by the at least one solvent removal element while the at least one interface is in contact with the porous surface.

9. The method of claim 1, wherein the at least one solvent removal element is non-reactive with the active substance.

10. The method of claim 1, wherein the at least one solvent removal element is apart from the interface.

11. The method of claim 1, wherein the transfer of the solution or dispersion of the at least one active substance from the at least one administration reservoir to the at least one interface is controlled by the removal of the at least one solvent from the at least one administration reservoir by the at least one solvent removal element.

12. The method of claim 1, wherein the at least one solvent removal element comprises evaporation.

13. The method of claim 12, wherein the at least one solvent removal element includes a heating element operable to support evaporation.

14. The method of claim 1, wherein the at least one solvent removal element is selected from a group consisting of a desiccant, a general or a selective absorbent material, silica gel, a molecular sieve and active carbon.

15. The method of claim 1, wherein transdermal administration of the at least one active substance is controlled by a control device.

16. The method of claim 15, wherein the control device is programmable according to a predetermined regime of the at least one active substance.

17. The method of claim 15, wherein the control device is communicatively coupled with at least one sensor operable to measure a condition of the at least one active substance within the at least one administration reservoir.

18. The method of claim 17, wherein the administration of the at least one active substance is based on a signal from the at least one sensor.

19. The method of claim 1, wherein the at least one substance reservoir, the at least one solvent reservoir, the at least one administration reservoir, the at least one interface, and the at least one solvent removal element are located within a housing.

20. The method of claim 1, wherein the active substance is selected from the group consisting of a nitrate, scopolamine, nitroglycerine, clonidine, an antihypertensive, an anti-adrenergic drug, a steroid hormone, 17-beta-estradiol, testosterone, an analgesic, fentanyl, nicotine-withdrawal drugs, nicotine, antibiotics, corticosteroids, minoxidil, retinoids, and Retin A.

21. A method for achieving a desired concentration of at least one active substance in a porous surface comprising contacting the porous surface with at least one interface operable to transfer at least one active substance from at least one administration reservoir to the porous surface, wherein the contacting comprises:

(a) delivering a first portion of the at least one active substance which is solubilized or dispersed in a solvent from the at least one administration reservoir to the at least one interface; and

(b) removing a second portion of the solvent from the at least one administration reservoir by a solvent removal element which functions to control the concentration of the at least one active substance in the porous surface.