Modified release dosage form
First Claim
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1. A medicinal dosage form comprising:
- a first core and a second core,wherein said first core comprises a first active ingredient and said second core comprises a second active ingredient,wherein said first core and said second core each have a diameter of at least about 6.35 millimeters, respectively, anda shell that is provided over and having a surface conforming or defining a first portion of said first core and a first portion of said second core,a first fill material provided over and having a surface conforming to or defining a second portion of said first core,wherein the first fill material does not overlap with the shell along the circumference of the core, wherein said fill material covers said second portion of said first core and said second portion of said second core exclusively and does not cover said first portion of said first core or said first portion of said second core,wherein the first active ingredient is released through the first fill material, and wherein the first active ingredient is not released through the shell, anda second fill material provided over and having a surface conforming to or defining a second portion of said second core,wherein the second fill material does not overlap with the shell along the circumference of the core,wherein the second active ingredient is released through the second fill material, andwherein the second active ingredient is not released through the shell;
wherein the first fill material in contact with said first core is not in contact with any portion of said second core,wherein the second fill material in contact with said second core is not in contact with any portion of said first core,wherein the first fill material provides for immediate release of the first active ingredient,wherein the second fill material provides for delayed, sustained, prolonged, extended, pH-dependent, or retarded release of the second active ingredient,wherein said first core and said second core are each selected from the group consisting of a tablet, a capsule, a suppository, a confectionery, a semi-solid in finished dosage form and a liquid in finished dosage form.
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Abstract
The present invention relates to a medicinal dosage form having a first core, a second core, and a shell that surrounds a first portion of each core and a fill material that covers a second portion of at least one core, wherein the fill material that is provided over at least one core is not in contact with any portion of the other core. e. The inventive dosage forms provide modified release of one or more active ingredients contained therein. The present invention also relates to methods for manufacturing such medicinal dosage forms.
234 Citations
10 Claims
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1. A medicinal dosage form comprising:
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a first core and a second core, wherein said first core comprises a first active ingredient and said second core comprises a second active ingredient, wherein said first core and said second core each have a diameter of at least about 6.35 millimeters, respectively, and a shell that is provided over and having a surface conforming or defining a first portion of said first core and a first portion of said second core, a first fill material provided over and having a surface conforming to or defining a second portion of said first core, wherein the first fill material does not overlap with the shell along the circumference of the core, wherein said fill material covers said second portion of said first core and said second portion of said second core exclusively and does not cover said first portion of said first core or said first portion of said second core, wherein the first active ingredient is released through the first fill material, and wherein the first active ingredient is not released through the shell, and a second fill material provided over and having a surface conforming to or defining a second portion of said second core, wherein the second fill material does not overlap with the shell along the circumference of the core, wherein the second active ingredient is released through the second fill material, and wherein the second active ingredient is not released through the shell; wherein the first fill material in contact with said first core is not in contact with any portion of said second core, wherein the second fill material in contact with said second core is not in contact with any portion of said first core, wherein the first fill material provides for immediate release of the first active ingredient, wherein the second fill material provides for delayed, sustained, prolonged, extended, pH-dependent, or retarded release of the second active ingredient, wherein said first core and said second core are each selected from the group consisting of a tablet, a capsule, a suppository, a confectionery, a semi-solid in finished dosage form and a liquid in finished dosage form. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10)
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Specification