Composition for glucose sensing comprising of nanofibrous membrane and method for manufacturing non-enzymatic glucose biosensor using the same

• US 8,673,386 B2
• Filed: 10/24/2008
• Issued: 03/18/2014
• Est. Priority Date: 07/29/2008
• Status: Active Grant

• Current Assignee: Kyungpook National University Industry-Academic Cooperation Foundation
• Original Assignee: Kyungpook National University Industry-Academic Cooperation Foundation
• Inventors: Lee, Kwang Pill, Anantha, Iyengar Gopalan, Shanmuga, Sundaram Komathi
• Primary Examiner(s): Mulcahy, Peter D.
• Assistant Examiner(s): HU, HENRY S
• Application Number:
  US13/056,151
• Publication Number:
  US 20110129593A1
• Time in Patent Office: 1,971 Days
• Field of Search: 427/2, 427/13, 427/2.11, 427/2.13, 204/415, 428/704
• US Class Current: 427/2.13
• CPC Class Codes: B82Y 15/00 Nanotechnology for interacting, sensing or actuating, e.g. quantum dots as markers in protein assays or molecular motors
• CPC Class Codes: B82Y 5/00 Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
• CPC Class Codes: G01N 33/66 involving blood sugars, e.g. galactose

Abstract

Disclosed herein is a composition for glucose sensing obtained by dispersing in a solvent such as acetone a nanofibrous membrane fabricated by electrospinning a mixture containing poly(vinylidene fluoride) and poly(aminophenylboronic acid). Also disclosed is a method of fabricating a non-enzymatic glucose biosensor based on an electrospun nanofibrous membrane by depositing the composition on an electrode.

Claims

1. A non-enzymatic glucose sensor comprising an electrode on which a polymer solution is deposited, wherein said polymer solution is, obtained by dispersing in a solvent a nanofibrous membrane fabricated by electrospinning a mixture comprising poly(vinylidene fluoride) and poly(aminophenylboronic acid).

2. The non-enzymatic glucose sensor of claim 1, wherein the poly(vinylidene fluoride) and the poly(aminophenylboronic acid) are present at a ratio of 90-99 wt %:

10-1 wt % based on the total weight of poly(vinylidene fluoride) and the poly(aminophenylboronic acid).

3. The non-enzymatic glucose sensor of claim 1, wherein the solvent additionally comprises an additive.

4. The non-enzymatic glucose sensor of claim 1, wherein the solvent is one or more selected from the group consisting of hydrochloric acid, sulfuric acid, dimethylformamide, diethyl ether, acetone, chloroform, methanol, isopropyl alcohol, methyl ethyl ketone, tetrahydrofuran, toluene, benzene and xylene.